Nox4 (NADPH oxidase 4) - Rat Genome Database

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Gene: Nox4 (NADPH oxidase 4) Rattus norvegicus
Analyze
Symbol: Nox4
Name: NADPH oxidase 4
RGD ID: 620600
Description: Enables NAD(P)H oxidase H2O2-forming activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and cellular response to mercury ion. Located in several cellular components, including endoplasmic reticulum; focal adhesion; and stress fiber. Part of NADPH oxidase complex. Used to study hypertension. Biomarker of hypertension; metabolic dysfunction-associated steatohepatitis; obesity; and steatotic liver disease. Orthologous to human NOX4 (NADPH oxidase 4); PARTICIPATES IN thyroid hormone biosynthetic pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (R)-lipoic acid; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kidney oxidase-1; kidney superoxide-producing NADPH oxidase; kox-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nox4em2Mcwi ; Nox4em1Mcwi ; Nox4em1Shmo
Genetic Models: F344-Cybbem1ShmoNox1em1ShmoNox4em1Shmo ; F344-Nox4em1Shmo ; SS-Nox4em2Mcwi-/- ; SS-Nox4em1Mcwi ; SS-Nox4em2Mcwi ; SS-Nox4em2Mcwi-/+ ; SS-Nox4em2Ncf2em1Mcwi
Is Marker For: Strains:   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,313,736 - 150,491,480 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1150,313,728 - 150,491,483 (+)EnsemblGRCr8
mRatBN7.21140,900,886 - 141,078,844 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1140,901,097 - 141,077,406 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1148,877,339 - 149,042,590 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01156,047,993 - 156,213,233 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01148,921,890 - 149,087,126 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01150,796,359 - 150,976,186 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1150,797,084 - 150,976,194 (+)Ensemblrn6Rnor6.0
Rnor_5.01157,246,099 - 157,285,107 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01157,106,652 - 157,196,482 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41143,415,816 - 143,603,554 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1139,242,883 - 139,407,667 (+)NCBICelera
RGSC_v3.11143,494,221 - 143,681,960 (+)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(R)-lipoic acid  (EXP,ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,4-benzoquinone  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
agomelatine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
amitrole  (EXP)
amlodipine  (EXP)
ammonium chloride  (EXP)
amsacrine  (ISO)
angiotensin II  (ISO)
antirheumatic drug  (ISO)
apocynin  (EXP,ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP,ISO)
aucubin  (ISO)
bellidifolin  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bosentan  (ISO)
bromobenzene  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium oxalate  (EXP)
candesartan  (EXP,ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carteolol  (ISO)
carvacrol  (EXP)
CGP-42112A  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
colistin  (EXP,ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
cytarabine  (ISO)
D-glucose  (EXP,ISO)
dapsone  (ISO)
daunorubicin  (EXP,ISO)
decabromodiphenyl ether  (EXP,ISO)
Deoxycorticosterone acetate  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenziodolium  (ISO)
dichloroacetic acid  (ISO)
diethyl phthalate  (ISO)
dihydrogen  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
diprotium  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethoxyquin  (EXP)
farrerol  (EXP)
fenthion  (ISO)
ferric oxide  (ISO)
fisetin  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (EXP)
furan  (EXP)
galactose  (EXP)
ginkgolide B  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyoxylic acid  (EXP)
GW 6471  (EXP)
Harpagoside  (ISO)
hesperetin  (ISO)
homocysteine  (ISO)
hydrazine  (ISO)
hydrochlorothiazide  (EXP)
hydrogen peroxide  (ISO)
hydrogen sulfide  (EXP)
hydroquinone  (ISO)
hydroxylamine  (EXP)
Ile(5)-angiotensin II  (ISO)
indoxyl sulfate  (ISO)
inulin  (ISO)
isoprenaline  (EXP,ISO)
kaempferol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lanthanum trichloride  (EXP)
lead diacetate  (ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
Leonurine  (EXP,ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (ISO)
liraglutide  (ISO)
loganin  (ISO)
lutein  (ISO)
LY294002  (ISO)
mancozeb  (ISO)
manidipine  (EXP)
melatonin  (EXP,ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methyl vanillate  (ISO)
methylphenidate  (ISO)
microcystin-LR  (EXP,ISO)
mitogen  (EXP)
monocrotaline  (EXP)
Morroniside  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naringin  (ISO)
neohesperidin  (ISO)
nicotinamide  (EXP)
nicotine  (ISO)
nicotinic acid  (EXP)
nitroglycerin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PD123319  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (ISO)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
phosphatidylcholine  (ISO)
pioglitazone  (EXP)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium iodide  (EXP)
probenecid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
roflumilast  (ISO)
rotenone  (EXP,ISO)
salubrinal  (ISO)
saxagliptin  (EXP)
SB 203580  (EXP)
selenium atom  (ISO)
sevoflurane  (EXP)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirtinol  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
telmisartan  (EXP)
teprenone  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
thymoquinone  (EXP)
titanium dioxide  (ISO)
torcetrapib  (ISO)
trans-piceid  (EXP)
trichloroethene  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
tyrphostin AG 1478  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
venetoclax  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells. Aguado A, etal., J Hypertens. 2016 Feb;34(2):253-65. doi: 10.1097/HJH.0000000000000801.
2. Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. Ambasta RK, etal., J Biol Chem. 2004 Oct 29;279(44):45935-41. Epub 2004 Aug 18.
3. Subcellular localization of Nox4 and regulation in diabetes. Block K, etal., Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14385-90. Epub 2009 Aug 17.
4. Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity. Carmona-Cuenca I, etal., J Hepatol. 2008 Dec;49(6):965-76. Epub 2008 Sep 19.
5. NADPH oxidase mediates radiation-induced oxidative stress in rat brain microvascular endothelial cells. Collins-Underwood JR, etal., Free Radic Biol Med. 2008 Sep 15;45(6):929-38. Epub 2008 Jun 30.
6. H2O2 activates Nox4 through PLA2-dependent arachidonic acid production in adult cardiac fibroblasts. Colston JT, etal., FEBS Lett. 2005 Apr 25;579(11):2533-40.
7. Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats. Cowley AW Jr, etal., Hypertension. 2016 Feb;67(2):440-50. doi: 10.1161/HYPERTENSIONAHA.115.06280. Epub 2015 Dec 7.
8. The role of NOX2 and "novel oxidases" in airway chemoreceptor O(2) sensing. Cutz E, etal., Adv Exp Med Biol. 2009;648:427-38.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats. Gojo A, etal., Eur J Pharmacol. 2007 Jul 30;568(1-3):242-7. Epub 2007 Apr 20.
12. Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. Gorin Y, etal., J Biol Chem. 2005 Nov 25;280(47):39616-26. Epub 2005 Aug 31.
13. Modulation of chronic hypoxia-induced chemoreceptor hypersensitivity by NADPH oxidase subunits in rat carotid body. He L, etal., J Appl Physiol. 2010 May;108(5):1304-10. Epub 2010 Feb 25.
14. Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Lassegue B, etal., Circ Res 2001 May 11;88(9):888-94.
15. Spinal Cord Injury Leads to Hyperoxidation and Nitrosylation of Skeletal Muscle Ryanodine Receptor-1 Associated with Upregulation of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4. Liu XH, etal., J Neurotrauma. 2017 Jun 15;34(12):2069-2074. doi: 10.1089/neu.2016.4763. Epub 2017 Feb 27.
16. Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis. Matsunami T, etal., Int J Clin Exp Pathol. 2010 May 22;3(5):472-81.
17. Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling. Matsushima S, etal., J Clin Invest. 2016 Sep 1;126(9):3403-16. doi: 10.1172/JCI85624. Epub 2016 Aug 15.
18. Early increase of Nox4 NADPH oxidase and superoxide generation following endothelin-1-induced stroke in conscious rats. McCann SK, etal., J Neurosci Res. 2008 Aug 15;86(11):2524-34.
19. Upregulation of Nox4 in the aging vasculature and its association with smooth muscle cell polyploidy. McCrann DJ, etal., Cell Cycle. 2009 Mar 15;8(6):902-8. Epub 2009 Mar 21.
20. Insulin-like growth factor-I induces reactive oxygen species production and cell migration through Nox4 and Rac1 in vascular smooth muscle cells. Meng D, etal., Cardiovasc Res. 2008 Nov 1;80(2):299-308. Epub 2008 Jun 20.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Mercury exposure induces proinflammatory enzymes in vascular fibroblasts. Millán Longo A, etal., Clin Investig Arterioscler. 2017 Nov-Dec;29(6):231-238. doi: 10.1016/j.arteri.2017.07.002. Epub 2017 Sep 19.
23. Differential impacts of mineralocorticoid receptor antagonist potassium canrenoate on liver and renal changes in high fat diet-mediated early hepatocarcinogenesis model rats. Nakamura M, etal., J Toxicol Sci. 2018;43(10):611-621. doi: 10.2131/jts.43.611.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice. Nisbet RE, etal., Am J Respir Cell Mol Biol. 2009 May;40(5):601-9. Epub 2008 Oct 23.
26. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Reduced levels of cyclic AMP contribute to the enhanced oxidative stress in vascular smooth muscle cells from spontaneously hypertensive rats. Saha S, etal., Can J Physiol Pharmacol. 2008 Apr;86(4):190-8.
31. The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms. Sancho P, etal., Biochim Biophys Acta. 2009 Feb;1793(2):253-63. Epub 2008 Sep 24.
32. Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4. Sun QA, etal., Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16098-103. doi: 10.1073/pnas.1109546108. Epub 2011 Sep 6.
33. Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats. Tada Y, etal., Hypertension. 2009 Sep;54(3):552-7. Epub 2009 Jul 20.
34. Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia. Vallet P, etal., Neuroscience. 2005;132(2):233-8.
35. Ameliorative effect of berberine on endothelial dysfunction in diabetic rats induced by high-fat diet and streptozotocin. Wang C, etal., Eur J Pharmacol. 2009 Oct 12;620(1-3):131-7. Epub 2009 Aug 15.
36. Upregulation of Nox4 promotes angiotensin II-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing ADAM17 expression. Zeng SY, etal., Can J Cardiol. 2013 Oct;29(10):1310-9. doi: 10.1016/j.cjca.2013.04.026. Epub 2013 Jul 11.
37. Role of Nox4 and p67phox subunit of Nox2 in ROS production in response to increased tubular flow in the mTAL of Dahl salt-sensitive rats. Zheleznova NN, etal., Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F450-8. doi: 10.1152/ajprenal.00187.2016. Epub 2016 Jun 8.
Additional References at PubMed
PMID:10869423   PMID:11032835   PMID:11098048   PMID:12842860   PMID:14670934   PMID:16150729   PMID:16775014   PMID:17082491   PMID:17283869   PMID:17324585   PMID:17698723   PMID:17942966  
PMID:18431508   PMID:18474828   PMID:18554521   PMID:18559349   PMID:18624925   PMID:18760347   PMID:19038868   PMID:19056645   PMID:19204183   PMID:19574552   PMID:19910702   PMID:19926889  
PMID:20016382   PMID:20031578   PMID:20185797   PMID:20686447   PMID:20715105   PMID:20724704   PMID:21071935   PMID:21419746   PMID:21646815   PMID:21940672   PMID:22031600   PMID:22063193  
PMID:22195989   PMID:22566500   PMID:22873349   PMID:22875785   PMID:23022406   PMID:23033809   PMID:23144758   PMID:23225244   PMID:23271793   PMID:23393389   PMID:23624625   PMID:23722270  
PMID:23884197   PMID:23940049   PMID:24041960   PMID:24480752   PMID:24623966   PMID:24636100   PMID:24872317   PMID:24947524   PMID:25203114   PMID:25410908   PMID:25681565   PMID:26088607  
PMID:26136558   PMID:26279425   PMID:26387612   PMID:26631573   PMID:26945889   PMID:27033446   PMID:27558234   PMID:27665186   PMID:27847553   PMID:27913300   PMID:27923787   PMID:27929749  
PMID:28011270   PMID:28063381   PMID:28078487   PMID:28330417   PMID:28431936   PMID:28447737   PMID:28634073   PMID:28751569   PMID:28805491   PMID:29087944   PMID:29147462   PMID:29672130  
PMID:29723859   PMID:29793963   PMID:30316800   PMID:30354218   PMID:30551445   PMID:30610956   PMID:30953402   PMID:31065679   PMID:31179339   PMID:31216444   PMID:31541678   PMID:32182821  
PMID:32183375   PMID:32233792   PMID:32311288   PMID:32776539   PMID:32799394   PMID:33001475   PMID:33273999   PMID:33470533   PMID:33515385   PMID:34396450   PMID:34435888   PMID:34834085  
PMID:35029280   PMID:35935259   PMID:36043333   PMID:36166507   PMID:36662655   PMID:37002575   PMID:37501791   PMID:37985134   PMID:37985248   PMID:38237016  


Genomics

Comparative Map Data
Nox4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,313,736 - 150,491,480 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1150,313,728 - 150,491,483 (+)EnsemblGRCr8
mRatBN7.21140,900,886 - 141,078,844 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1140,901,097 - 141,077,406 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1148,877,339 - 149,042,590 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01156,047,993 - 156,213,233 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01148,921,890 - 149,087,126 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01150,796,359 - 150,976,186 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1150,797,084 - 150,976,194 (+)Ensemblrn6Rnor6.0
Rnor_5.01157,246,099 - 157,285,107 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.01157,106,652 - 157,196,482 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41143,415,816 - 143,603,554 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1139,242,883 - 139,407,667 (+)NCBICelera
RGSC_v3.11143,494,221 - 143,681,960 (+)NCBI
Cytogenetic Map1q32NCBI
NOX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381189,324,353 - 89,589,557 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1189,324,353 - 89,498,187 (-)Ensemblhg38GRCh38
GRCh371189,057,521 - 89,322,725 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361188,699,160 - 88,864,301 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341188,699,159 - 88,864,301NCBI
Celera1185,399,612 - 85,574,418 (+)NCBICelera
Cytogenetic Map11q14.3NCBI
HuRef1185,294,642 - 85,559,923 (-)NCBIHuRef
CHM1_11188,940,465 - 89,205,767 (-)NCBICHM1_1
T2T-CHM13v2.01189,244,014 - 89,509,286 (-)NCBIT2T-CHM13v2.0
Nox4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39786,893,638 - 87,047,918 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl786,895,304 - 87,047,918 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38787,244,430 - 87,398,710 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl787,246,096 - 87,398,710 (+)Ensemblmm10GRCm38
MGSCv37794,395,305 - 94,547,116 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36787,122,556 - 87,274,367 (+)NCBIMGSCv36mm8
Celera784,613,741 - 84,757,901 (+)NCBICelera
Cytogenetic Map7D3NCBI
cM Map748.96NCBI
Nox4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554144,062,081 - 4,212,746 (+)Ensembl
ChiLan1.0NW_0049554144,062,337 - 4,220,032 (+)NCBIChiLan1.0ChiLan1.0
NOX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2990,148,233 - 90,362,455 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11191,239,494 - 91,406,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01184,330,362 - 84,496,755 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11187,911,335 - 88,171,535 (-)NCBIPanPan1.1PanPan1.1panPan2
NOX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12110,615,153 - 10,782,927 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2110,615,970 - 10,775,277 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2110,465,855 - 10,632,710 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02110,796,288 - 10,963,304 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2110,795,550 - 10,960,296 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12110,584,756 - 10,745,644 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02110,643,276 - 10,811,261 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02110,699,999 - 10,861,437 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nox4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494774,947,435 - 75,112,097 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936736230,476 - 396,708 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936736230,465 - 394,859 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl922,624,212 - 22,776,534 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1922,622,105 - 22,776,691 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2925,234,530 - 25,427,884 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1180,470,418 - 80,642,513 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl180,470,826 - 80,642,722 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604345,091,781 - 45,259,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nox4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624845669,902 - 827,834 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624845669,880 - 829,471 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nox4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12113,891,688 - 114,044,061 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nox4
1361 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir92brno-miR-92b-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeNon-Functional MTI21071935
Mir25rno-miR-25-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCR//WeFunctional MTI21071935

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:148
Interacting mature miRNAs:162
Transcripts:ENSRNOT00000018990
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1112521556157521556Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132889797152403053Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1142582180153680016Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1124975316152612788Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1110389869155389869Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1108680016153680016Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1112521556157521556Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1111949780160574007Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429152404087Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat

Markers in Region
AU047304  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21140,980,579 - 140,980,729 (+)MAPPERmRatBN7.2
Rnor_6.01150,876,500 - 150,876,649NCBIRnor6.0
Rnor_5.01157,185,521 - 157,185,670UniSTSRnor5.0
RGSC_v3.41143,496,029 - 143,496,178UniSTSRGSC3.4
Celera1139,323,472 - 139,323,621UniSTS
Cytogenetic Map1q32UniSTS


Related Rat Strains
The following Strains have been annotated to Nox4
FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi    


Genetic Models
This gene Nox4 is modified in the following models/strains:
F344-Cybbem1ShmoNox1em1ShmoNox4em1Shmo     F344-Nox4em1Shmo     SS-Nox4em2Mcwi-/-     SS-Nox4em1Mcwi     SS-Nox4em2Mcwi     SS-Nox4em2Mcwi-/+     SS-Nox4em2Ncf2em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 12 66 129 72 71 40 28 40 6 271 127 11 108 81 87 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000018990   ⟹   ENSRNOP00000018990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1150,313,728 - 150,488,742 (+)Ensembl
mRatBN7.2 Ensembl1140,901,097 - 141,076,106 (+)Ensembl
Rnor_6.0 Ensembl1150,797,084 - 150,976,194 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102096   ⟹   ENSRNOP00000085650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1150,313,728 - 150,491,470 (+)Ensembl
mRatBN7.2 Ensembl1140,901,173 - 141,077,406 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116153   ⟹   ENSRNOP00000079906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1150,313,728 - 150,491,470 (+)Ensembl
mRatBN7.2 Ensembl1140,901,173 - 141,077,406 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131019   ⟹   ENSRNOP00000106633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1150,313,729 - 150,491,483 (+)Ensembl
RefSeq Acc Id: NM_053524   ⟹   NP_445976
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,313,889 - 150,490,031 (+)NCBI
mRatBN7.21140,901,243 - 141,077,395 (+)NCBI
Rnor_6.01150,797,202 - 150,974,737 (+)NCBI
Rnor_5.01157,106,652 - 157,196,482 (+)NCBI
Rnor_5.01157,246,099 - 157,285,107 (+)NCBI
RGSC_v3.41143,415,816 - 143,603,554 (+)RGD
Celera1139,242,883 - 139,407,667 (+)RGD
Sequence:
RefSeq Acc Id: XM_008759643   ⟹   XP_008757865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,313,736 - 150,491,480 (+)NCBI
mRatBN7.21140,900,886 - 141,078,844 (+)NCBI
Rnor_6.01150,797,084 - 150,976,186 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039092943   ⟹   XP_038948871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,313,738 - 150,491,480 (+)NCBI
mRatBN7.21140,900,888 - 141,078,844 (+)NCBI
RefSeq Acc Id: XM_039092944   ⟹   XP_038948872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,313,952 - 150,491,480 (+)NCBI
mRatBN7.21140,901,316 - 141,078,844 (+)NCBI
RefSeq Acc Id: NP_445976   ⟸   NM_053524
- UniProtKB: Q99M78 (UniProtKB/Swiss-Prot),   Q924V1 (UniProtKB/Swiss-Prot),   A6I5Y4 (UniProtKB/TrEMBL),   A0A8I5ZPH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757865   ⟸   XM_008759643
- Peptide Label: isoform X3
- UniProtKB: A6I5Y3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018990   ⟸   ENSRNOT00000018990
RefSeq Acc Id: XP_038948871   ⟸   XM_039092943
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZPH8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948872   ⟸   XM_039092944
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZPH8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085650   ⟸   ENSRNOT00000102096
Ensembl Acc Id: ENSRNOP00000079906   ⟸   ENSRNOT00000116153
Ensembl Acc Id: ENSRNOP00000106633   ⟸   ENSRNOT00000131019
Protein Domains
FAD-binding FR-type   Ferric oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q924V1-F1-model_v2 AlphaFold Q924V1 1-578 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690176
Promoter ID:EPDNEW_R701
Type:initiation region
Name:Nox4_1
Description:NADPH oxidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R702  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01150,797,096 - 150,797,156EPDNEW
RGD ID:13690177
Promoter ID:EPDNEW_R702
Type:initiation region
Name:Nox4_2
Description:NADPH oxidase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R701  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01150,797,201 - 150,797,261EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620600 AgrOrtholog
BioCyc Gene G2FUF-58588 BioCyc
Ensembl Genes ENSRNOG00000013925 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000102096 ENTREZGENE
  ENSRNOT00000102096.1 UniProtKB/Swiss-Prot
  ENSRNOT00000131019 ENTREZGENE
Gene3D-CATH 3.40.50.80 UniProtKB/Swiss-Prot
  Translation factors UniProtKB/Swiss-Prot
InterPro Cyt_b245_heavy_chain UniProtKB/Swiss-Prot
  FAD-bd_8 UniProtKB/Swiss-Prot
  FAD-bd_FR_type UniProtKB/Swiss-Prot
  Fe3_Rdtase_TM_dom UniProtKB/Swiss-Prot
  Fe_red_NAD-bd_6 UniProtKB/Swiss-Prot
  FNR_nucleotide-bd UniProtKB/Swiss-Prot
  RBOH/FRE UniProtKB/Swiss-Prot
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot
KEGG Report rno:85431 UniProtKB/Swiss-Prot
NCBI Gene 85431 ENTREZGENE
PANTHER NADPH OXIDASE UniProtKB/Swiss-Prot
  NADPH OXIDASE 4 UniProtKB/Swiss-Prot
Pfam FAD_binding_8 UniProtKB/Swiss-Prot
  Ferric_reduct UniProtKB/Swiss-Prot
  NAD_binding_6 UniProtKB/Swiss-Prot
PhenoGen Nox4 PhenoGen
PRINTS GP91PHOX UniProtKB/Swiss-Prot
PROSITE FAD_FR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013925 RatGTEx
Superfamily-SCOP SSF52343 UniProtKB/Swiss-Prot
  SSF63380 UniProtKB/Swiss-Prot
UniProt A0A8I5ZPH8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q9R0_RAT UniProtKB/TrEMBL
  A0ABK0L8S3_RAT UniProtKB/TrEMBL
  A6I5Y3 ENTREZGENE, UniProtKB/TrEMBL
  A6I5Y4 ENTREZGENE, UniProtKB/TrEMBL
  A6I5Y5_RAT UniProtKB/TrEMBL
  NOX4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q99M78 ENTREZGENE
UniProt Secondary Q99M78 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Nox4  NADPH oxidase 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Nox4  NADPH oxidase 4      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression highly expressed in vascular smooth muscle cells 632514
gene_regulation expression is downregulated by platelet-derived growth factor (PDGF) and Ang II 632514