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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620600
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nox4
Name: NADPH oxidase 4
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nox4increases expressionEXP 6480464CTDDoxorubicin results in increased expression of NOX4 mRNA; Doxorubicin results in increased expression of NOX4 proteinPMID:18371937 PMID:25268985
Nox4multiple interactionsEXP 6480464CTDDoxorubicin promotes the reaction [RTKI cpd results in increased expression of NOX4 mRNA]; thymoquinone inhibits the reaction [Doxorubicin results in increased expression of NOX4 protein]PMID:18371937 PMID:25268985
Nox4increases expressionISONox4 (Mus musculus)6480464CTDDoxorubicin results in increased expression of NOX4 mRNA; Doxorubicin results in increased expression of NOX4 proteinPMID:25896364 PMID:31158416 PMID:34296331
Nox4multiple interactionsISONox4 (Mus musculus)6480464CTDcorosolic acid inhibits the reaction [Doxorubicin results in increased expression of NOX4 mRNA]PMID:34296331
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