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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620600
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nox4
Name: NADPH oxidase 4
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nox4decreases expressionISONox4 (Mus musculus)6480464CTDParaquat results in decreased expression of NOX4 mRNAPMID:21688324
Nox4increases expressionISONOX4 (Homo sapiens)6480464CTDParaquat results in increased expression of NOX4 mRNAPMID:20164675 PMID:25177032
Nox4increases expressionISONox4 (Mus musculus)6480464CTDParaquat results in increased expression of NOX4 mRNAPMID:21765237 PMID:29273418
Nox4multiple interactionsISONOX4 (Homo sapiens)6480464CTDDapsone inhibits the reaction [Paraquat results in increased expression of NOX4 mRNA]; kaempferol inhibits the reaction [Paraquat results in increased expression of NOX4 mRNA]PMID:20164675 PMID:25177032
Nox4multiple interactionsISONox4 (Mus musculus)6480464CTDAPOD protein affects the reaction [Paraquat results in decreased expression of NOX4 mRNA]; Dapsone inhibits the reaction [Paraquat results in increased expression of NOX4 mRNA]; pirfenidone inhibits the reaction [Paraquat results in increased expression of NOX4 mRNA]PMID:21688324 PMID:21765237 PMID:29273418
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