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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620600
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nox4
Name: NADPH oxidase 4
Acc ID: CHEBI:17823
Term: calcitriol
Definition: A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.
Chemical ID: MESH:D002117
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nox4decreases expressionEXP 6480464CTDCalcitriol results in decreased expression of NOX4 mRNA; Calcitriol results in decreased expression of NOX4 proteinPMID:32147540
Nox4increases expressionISONOX4 (Homo sapiens)6480464CTDCalcitriol results in increased expression of NOX4 mRNAPMID:19918113
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