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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620600
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nox4
Name: NADPH oxidase 4
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nox4decreases expressionISONOX4 (Homo sapiens)6480464CTDcobaltous chloride results in decreased expression of NOX4 mRNAPMID:19320972
Nox4decreases expressionISONox4 (Mus musculus)6480464CTDcobaltous chloride results in decreased expression of NOX4 mRNA; cobaltous chloride results in decreased expression of NOX4 proteinPMID:24412703
Nox4increases expressionISONox4 (Mus musculus)6480464CTDcobaltous chloride results in increased expression of NOX4 mRNA; cobaltous chloride results in increased expression of NOX4 proteinPMID:16507596
Nox4multiple interactionsISONox4 (Mus musculus)6480464CTDPOMC protein modified form inhibits the reaction [cobaltous chloride results in decreased expression of NOX4 mRNA]; POMC protein modified form inhibits the reaction [cobaltous chloride results in decreased expression of NOX4 protein]PMID:24412703
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