GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nox4 | increases expression | EXP | | 6480464 | CTD | Oxygen deficiency results in increased expression of NOX4 mRNA; Oxygen deficiency results in increased expression of NOX4 protein | PMID:24492474 PMID:27313889 PMID:31629700 PMID:34478853 | Nox4 | multiple interactions | EXP | | 6480464 | CTD | [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NOX4 mRNA; [Semaxinib co-treated with Oxygen deficiency] results in increased expression of NOX4 mRNA; Antigen-Antibody Complex inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NOX4 mRNA]; BQ 788 inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 mRNA]; BQ 788 inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 protein]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 mRNA]; Resveratrol inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 protein]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 mRNA]; saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 protein] | PMID:24492474 PMID:24947524 PMID:29702141 PMID:31629700 PMID:34478853 | Nox4 | increases expression | ISO | NOX4 (Homo sapiens) | 6480464 | CTD | Oxygen deficiency results in increased expression of NOX4 mRNA; Oxygen deficiency results in increased expression of NOX4 protein | PMID:19520921 PMID:26516004 PMID:26906511 PMID:35883890 | Nox4 | increases expression | ISO | Nox4 (Mus musculus) | 6480464 | CTD | Oxygen deficiency results in increased expression of NOX4 mRNA; Oxygen results in increased expression of NOX4 mRNA; Oxygen results in increased expression of NOX4 protein | PMID:19520921 PMID:35848756 | Nox4 | multiple interactions | ISO | NOX4 (Homo sapiens) | 6480464 | CTD | diphenyleneiodonium inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 protein]; Folic Acid inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 protein]; NOX4 protein promotes the reaction [Oxygen deficiency results in increased expression of and results in increased activity of HIF1A protein]; NOX4 protein promotes the reaction [sodium arsenite inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of HIF1A protein]]; Rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 mRNA]; U 0126 inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 protein] | PMID:19520921 PMID:26906511 PMID:27286880 | Nox4 | multiple interactions | ISO | Nox4 (Mus musculus) | 6480464 | CTD | [CAV1 gene mutant form results in increased susceptibility to Oxygen deficiency] which results in increased expression of NOX4 mRNA; [CAV1 gene mutant form results in increased susceptibility to Oxygen deficiency] which results in increased expression of NOX4 protein; [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of NOX4 mRNA; MIR34C promotes the reaction [Oxygen results in increased expression of NOX4 mRNA]; MIR34C promotes the reaction [Oxygen results in increased expression of NOX4 protein]; Rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of NOX4 mRNA]; SRT1720 inhibits the reaction [Oxygen results in decreased expression of NOX4 mRNA]; SRT1720 inhibits the reaction [Oxygen results in decreased expression of NOX4 protein] | PMID:19520921 PMID:24835767 PMID:30529165 PMID:35848756 | | ||||||||||||||||||||||
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