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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620600
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nox4
Name: NADPH oxidase 4
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nox4affects expressionISONox4 (Mus musculus)6480464CTDValproic Acid affects the expression of NOX4 mRNAPMID:17963808
Nox4decreases methylationISONOX4 (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of NOX4 genePMID:29154799
Nox4increases expressionISONOX4 (Homo sapiens)6480464CTDValproic Acid results in increased expression of NOX4 mRNAPMID:23179753
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