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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620600
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nox4
Name: NADPH oxidase 4
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nox4multiple interactionsISONOX4 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Particulate Matter results in increased expression of NOX4 mRNA]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of NOX4 protein]; Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of NOX4 mRNA]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of NOX4 protein]PMID:21131394 PMID:24224404
Nox4multiple interactionsISONox4 (Mus musculus)6480464CTDAcetylcysteine inhibits the reaction [mancozeb results in increased expression of NOX4 mRNA]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of AIF1 protein]]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of CS protein]]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of HK2 protein]]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of IL1B protein]]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of IL6 protein]]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of PKM protein]]; Acetylcysteine inhibits the reaction [NOX4 protein promotes the reaction [[Lipopolysaccharides co-treated with IFNG1 protein] results in increased expression of TNF protein]]; Acetylcysteine inhibits the reaction [salubrinal results in increased expression of [Cisplatin results in increased expression of NOX4 protein]]PMID:21616140 PMID:30037311 PMID:36762617
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