Crebbp Rat Gene (CREB binding protein)

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Keyword

Gene:
Crebbp ( Rattus norvegicus )
CREB binding protein
Description: a transcriptional co-activator; has an important role in hormone-dependent female sexual behavior and long term memory
Synonyms: RSTS; Creb binding protein (CBP); RTS; CBP;
ArrayIDs: 5709664; 5627363; 5970924; 6495466; 5620653; 6587848; 1387619_at; 5798521; 6130958; 5813637; 5961828; 6431430; 6323313; 6118312; 5861244; 6097403; 5813461; 1385852_at; 5922820; 6300257; 6002149; 6551585; 6641471; 6362187; 6399301; 5668374; 6043530; 6165634; 6458237; 6302519; 1382264_at; 6623238; 6720684; 5819065; 5948925; 5922746; 6226215; 6505243; 5749917; 6287282; rc_AI137114_at; 6652492; 5814587; 5979400; 6695962; 5945025; 6700944; 6711659; 6175308;  (details...)
Gene Type: protein-coding

Additional Data

Homologs
Homo sapiens: CREBBP     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Crebbp     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Crebbp genome assembly 3.1 10 11598679 - 11724107
Rat Celera Assembly 10 10292190 - 10417044
RGSC genome assembly v3.4 10 11598680 - 11724122
Cytogenetic 10 q12
Mus musculus Crebbp Mouse genome assembly build 36.1 16 4084048 - 4213404
Cytogenetic 16 16 A1
Homo sapiens CREBBP human genome assembly 16 3716569 - 3870712
Human genome assembly build 36.2 16 3716568 - 3870712
Cytogenetic 16 p13.3

View comparative maps:      NCBI MapViewer

Genome
View:

Browsers:

Annotation
Molecular Function

Note Reference

nuclear receptor coactivator 70390

Gene Ontology

zinc ion binding,  transcription factor activity,  transcription coactivator activity ... (details...)
Biological Process

Note Reference

may have a role in long-term memory 1298598

increases estrogen receptor transcriptional activity and regulates hormone-dependent female sexual behavior 70390

Gene Ontology

regulation of transcription, DNA-dependent,  N-terminal peptidyl-lysine acetylation,  positive regulation of transcription from RNA polymerase II promoter ... (details...)
Cellular Component

Gene Ontology

transcription factor complex,  protein complex,  nucleus ... (details...)
Disease

Note Reference

upregulated in Rubenstein-Taybi syndrome 70390

Ontology

Leukemia, Myelocytic, Acute,  Rubinstein-Taybi Syndrome (details...)
Phenotype

Ontology

cardiac hypertrophy (details...)
Expression

Note Reference

expression decreases in the cerebral cortex and hippocampus of aged rats 1298795

expressed in brain 70390

Pathway

Ontology

transforming growth factor-beta Smad dependent signaling pathway,  Huntington disease pathway,  transforming growth factor-beta signaling pathway ... (details...)

External Links
Databases
DATABASE ID SOURCE
SMART: ZnF_ZZ IPI
SMART: BROMO IPI
SMART: ZnF_TAZ IPI
PROSITE: ZF_ZZ_2 IPI
PROSITE: ZF_ZZ_1 IPI
PROSITE: BROMODOMAIN_1 IPI
PROSITE: BROMODOMAIN_2 IPI
PROSITE: KIX IPI
PROSITE: ZF_TAZ IPI
UNIPARC: UPI000021DC9D IPI
UNIPARC: UPI00000031B4 IPI
KEGG Report: rno:54244 ENTREZGENE
HomoloGene Group ID: 68393 ENTREZGENE
Germonline: 2401
Pfam: ZZ IPI
Pfam: zf-TAZ IPI
Pfam: KIX IPI
Pfam: Bromodomain IPI
Pfam: Creb_binding IPI
Pfam: DUF902 IPI
Pfam: DUF906 IPI
KEGG Pathway: 04630 ENTREZGENE
KEGG Pathway: 04720 ENTREZGENE
KEGG Pathway: 05016 ENTREZGENE
KEGG Pathway: 04310 ENTREZGENE
KEGG Pathway: 04350 ENTREZGENE
KEGG Pathway: 05211 ENTREZGENE
KEGG Pathway: 05215 ENTREZGENE
KEGG Pathway: 05200 ENTREZGENE
KEGG Pathway: 04330 ENTREZGENE
KEGG Pathway: 04916 ENTREZGENE
KEGG Pathway: 04520 ENTREZGENE
KEGG Pathway: 04110 ENTREZGENE
InterPro: Znf_TAZ. IPI
InterPro: Znf_ZZ. IPI
InterPro: Trans_coact. IPI
InterPro: Bromodomain. IPI
InterPro: Bromodomain_CS. IPI
InterPro: DUF902_CREBbp. IPI
InterPro: KIX. IPI
InterPro: Nuc_rcpt_coact. IPI
InterPro: Nuc_rcpt_coact_CREBbp. IPI
IPI: IPI00781902 IPI
IPI: IPI00561522 IPI
Ensembl Protein: ENSRNOP00000007079 IPI
Ensembl Protein: ENSRNOP00000045985 IPI
Gene3D-CATH: Bromodomain IPI
Gene3D-CATH: KIX IPI
Gene3D-CATH: Znf_TAZ IPI
Gene3D-CATH: Nuc_rcpt_coact_CREBbp IPI
Entrez Gene: Crebbp ENTREZGENE
UniProt: Q6JHU9_RAT IPI
UniProt: Q812C2_RAT IPI
UniProt: Q812C1_RAT IPI
UniProt: Q91XT1_RAT IPI
Ensembl Genes: ENSRNOG00000005330 IPI
RatMap: 44533 ENTREZGENE
Superfamily-SCOP: TAZ_finger IPI
Superfamily-SCOP: Nuc_recept_coact IPI
Superfamily-SCOP: Bromodomain IPI
Superfamily-SCOP: KIX IPI
PRINTS: BROMODOMAIN. IPI
Sequences
Nucleotide: NM_133381 Get FASTA Search GEO Profiles
Nucleotide: AF410813 Get FASTA Search GEO Profiles
Nucleotide: AY462245 Get FASTA Search GEO Profiles
Nucleotide: AB066219 Get FASTA Search GEO Profiles
Nucleotide: AF410812 Get FASTA Search GEO Profiles
(View all 5 Nucleotide Accessions)
Protein: NP_596872 Get FASTA
Protein: AAN39140 Get FASTA
Protein: AAN39141 Get FASTA
Protein: BAB62424 Get FASTA
Protein: AAR23149 Get FASTA
Protein: Q6JHU9 Get FASTA
Protein: Q812C1 Get FASTA
Protein: Q812C2 Get FASTA
Protein: Q91XT1 Get FASTA
(View all 9 Protein Accessions)
Clusters
UniGene: 108128

References
Curated References
23 references in RGD related to Crebbp

Other References
42 other references at PubMed related to Crebbp

Database Information
RGD ID 2401
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

06-NOV-02: Crebbp CREB binding protein Creb binding protein (CBP) APPROVED Name updated 625702

10-JUN-02: Crebbp Creb binding protein (CBP) APPROVED Symbol and Name status set to approved 70586