RGD Reference Report - Cocaine self-administration in rats lacking a functional trpc4 gene. - Rat Genome Database

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Cocaine self-administration in rats lacking a functional trpc4 gene.

Authors: Rasmus, Kristin C  O'Neill, Casey E  Bachtell, Ryan K  Cooper, Donald C 
Citation: Rasmus KC, etal., F1000Res. 2013 Apr 17;2:110. doi: 10.12688/f1000research.2-110.v1. eCollection 2013.
RGD ID: 126848805
Pubmed: PMID:24555056   (View Abstract at PubMed)
PMCID: PMC3901450   (View Article at PubMed Central)
DOI: DOI:10.12688/f1000research.2-110.v1   (Journal Full-text)

The canonical transient receptor potential (TRPC) family of Ca (2+) permeable, non-selective cation channels is abundantly expressed throughout the brain, and plays a pivotal role in modulating cellular excitability. Unlike other TRPC channels, TRPC4 subtype expression in the adult rodent brain is restricted to a network of structures that receive dopaminergic innervation, suggesting an association with motivation- and reward-related behaviors. We hypothesized that these channels may play a critical role in dopamine-dependent drug-seeking behaviors. Here, we gathered data testing trpc4 knockout (KO) rats and wild-type (WT) littermates in the acquisition of a natural sucrose reward (10 days), and cocaine self-administration (13 days) at 0.5 mg/kg/infusion. Rats lacking the trpc4 gene ( trpc4-KO) learned to lever press for sucrose to a similar degree as their WT controls. However, when they were switched to cocaine, the trpc4-KO rats had substantially reduced cocaine-paired lever pressing compared to WT controls. No obvious group differences in inactive lever pressing were observed, for any time, during cocaine self-administration.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
behavioral response to cocaine  IMP 126848805 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abnormal acquisiton of operant behavior for a cocaine reinforcer  IMP 126848805; 126848805; 126848805 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Crebbp  (CREB binding protein)
Trpc4  (transient receptor potential cation channel, subfamily C, member 4)
Trpc4Tn(sb)Tngen  (transient receptor potential cation channel, subfamily C, member 4; sleeping beauty induced mutant, Tngen)

Strains
F344-Trpc4Tn(sb)1Bni  (NA)


Additional Information