Trpc4<sup>Tn(sb)Tngen</sup> (transient receptor potential cation channel, subfamily C, member 4; sleeping beauty induced mutant, Tngen) - Rat Genome Database

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Gene: Trpc4Tn(sb)Tngen (transient receptor potential cation channel, subfamily C, member 4; sleeping beauty induced mutant, Tngen) Rattus norvegicus
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Symbol: Trpc4Tn(sb)Tngen
Name: transient receptor potential cation channel, subfamily C, member 4; sleeping beauty induced mutant, Tngen
RGD ID: 126848808
Description: The Sleeping Beauty transposon system was used to insert the sleeping beauty transposon into the first intron of the rat Trpc4 gene. This insertion resulted in knockout of Trpc4.
ASSOCIATED WITH abnormal acquisiton of operant behavior for a cocaine reinforcer; ASSOCIATED WITH Pulmonary Arterial Hypertension
Type: allele  of Trpc4  
Previously known as: Trpc4^[Tn(sb)Tngen]
Is Marker For: Strains:   F344-Trpc4Tn(sb)1Bni  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. TRPC4 inactivation confers a survival benefit in severe pulmonary arterial hypertension. Alzoubi A, etal., Am J Pathol. 2013 Dec;183(6):1779-1788. doi: 10.1016/j.ajpath.2013.08.016. Epub 2013 Oct 8.
2. Loss of the trpc4 gene is associated with a reduction in cocaine self-administration and reduced spontaneous ventral tegmental area dopamine neuronal activity, without deficits in learning for natural rewards. Klipec WD, etal., Behav Brain Res. 2016 Jun 1;306:117-27. doi: 10.1016/j.bbr.2016.03.027. Epub 2016 Mar 14.
3. Cocaine self-administration in rats lacking a functional trpc4 gene. Rasmus KC, etal., F1000Res. 2013 Apr 17;2:110. doi: 10.12688/f1000research.2-110.v1. eCollection 2013.

Genomics


Related Rat Strains
The following Strains have been annotated to Trpc4Tn(sb)Tngen
F344-Trpc4Tn(sb)1Bni    


Expression


Sequence

Nucleotide Sequences


Additional Information