RNA POLYMERASE I TRANSCRIPTION PATHWAY (PW:0000126)

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Description

The three eukaryotic RNA polymerases (RNAPs)- Pol I, II and III, transcribe different sets of genes and require distinct sets of factors to assemble a specific initiation complex which recruits them on gene promoters. The multi-subunit enzymes are composed of 14 (RNAPI), 12 (RNAPII) and 17 (RNAPIII) sub-units of which some are shared and others are unique, yet converging on an overall similar structural topology. Complexes specific to each of the three systems share the universal transcription

Pathway Diagram:

Elsevier Inc. ribosome biogenesis pathway rRNA maturation pathway pre-rRNA transcript Sirt1 Sirt7 Sirt7 --+> RNA polymerase I normal conditions --+> RNA polymerase I Ncl ---> pre-rRNA transcript Crebbp ---| RNA polymerase I nucleolar stress --+> p53 signaling pathway nutrients stress conditions stress conditions ---| SL1 complex Sirt1 ---| SL1 complex stress conditions ---| Sirt7 stress conditions --+> adenosine monophosphate-activated protein kinase (AMPK) signaling pathway nutrients --+> mTOR signaling pathway nutrients --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway adenosine monophosphate-activated protein kinase (AMPK) signaling pathway ---| SL1 complex mTOR signaling pathway --+> SL1 complex the extracellular signal-regulated Raf/Mek/Erk signaling pathway --+> SL1 complex Ncl ---> ribosome biogenesis pathway Ncl ---> rRNA maturation pathway RNA polymerase I mTOR signaling pathway FACT complex Ncl chromatin modification/remodeling pathway Ptrf Ttf1 Supt4h1 Supt5h Crebbp Rrn3 Ubtf P- P+ SL1 complex Paf1 complex nucleolar stress Rrn3 ---- SL1 complex SL1 complex ---- Ubtf normal conditions RNA polymerase I ---> pre-rRNA transcript RNA polymerase I ---- Supt5h RNA polymerase I ---- Rrn3 Ptrf ---- Ttf1 Paf1 complex ---- Supt4h1 Paf1 complex ---- Supt5h Supt4h1 ---- Supt5h Supt5h ---> pre-rRNA transcript chromatin modification/remodeling pathway ---> pre-rRNA transcript FACT complex ---> pre-rRNA transcript p53 signaling pathway adenosine monophosphate-activated protein kinase (AMPK) signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway
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Genes in Pathway:

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RNA polymerase I transcription pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cavin1 caveolae associated protein 1 JBrowse link 10 88,862,513 88,874,495 RGD:9588249
G Cd3eap CD3e molecule associated protein JBrowse link 1 80,267,725 80,271,001 RGD:9588244
RGD:9588262
G Cdc73 cell division cycle 73 JBrowse link 13 60,403,771 60,496,511 RGD:9588246
G Crebbp CREB binding protein JBrowse link 10 11,590,994 11,721,039 RGD:9588250
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component JBrowse link 1 175,839,140 175,869,167 RGD:9588246
G Leo1 LEO1 homolog, Paf1/RNA polymerase II complex component JBrowse link 8 82,380,906 82,405,293 RGD:9588246
G Ncl nucleolin JBrowse link 9 93,369,119 93,377,643 RGD:9588244
RGD:9588251
G Paf1 PAF1 homolog, Paf1/RNA polymerase II complex component JBrowse link 1 85,362,421 85,367,999 RGD:9588246
G Polr1a RNA polymerase I subunit A JBrowse link 4 99,822,964 99,903,969 RGD:9588244
RGD:9588262
G Polr1b RNA polymerase I subunit B JBrowse link 3 121,632,043 121,656,506 RGD:9588244
RGD:9588262
G Polr1c RNA polymerase I subunit C JBrowse link 9 17,120,759 17,124,871 RGD:9588244
RGD:9588262
G Polr1e RNA polymerase I subunit E JBrowse link 5 60,572,573 60,588,097 RGD:9588244
RGD:9588262
G Polr2e RNA polymerase II subunit E JBrowse link 7 12,532,785 12,536,797 RGD:9588244
RGD:9588262
G Polr2f RNA polymerase II subunit F JBrowse link 7 120,380,543 120,392,214 RGD:9588244
RGD:9588262
G Polr2k RNA polymerase II subunit K JBrowse link 7 74,939,010 74,992,594 RGD:9588244
RGD:9588262
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor JBrowse link 10 3,170,387 3,214,648 RGD:9588243
RGD:9588244
G Rtf1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) JBrowse link 3 111,478,350 111,537,941 RGD:9588246
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:9588250
G Sirt7 sirtuin 7 JBrowse link 10 109,796,046 109,802,821 RGD:9588250
G Ssrp1 structure specific recognition protein 1 JBrowse link 3 72,447,516 72,457,621 RGD:9588245
G Supt16h SPT16 homolog, facilitates chromatin remodeling subunit JBrowse link 15 28,574,841 28,611,959 RGD:9588245
G Supt4h1 SPT4 homolog, DSIF elongation factor subunit JBrowse link 10 75,032,365 75,038,547 RGD:9588244
G Supt5h SPT5 homolog, DSIF elongation factor subunit JBrowse link 1 85,437,780 85,466,854 RGD:9588244
G Taf12 TATA-box binding protein associated factor 12 JBrowse link 5 150,459,701 150,476,521 RGD:9588243
RGD:9588244
G Taf1a TATA-box binding protein associated factor, RNA polymerase I subunit A JBrowse link 13 101,770,278 101,807,975 RGD:9588243
RGD:9588244
G Taf1b TATA-box binding protein associated factor, RNA polymerase I subunit B JBrowse link 6 43,644,931 43,722,124 RGD:9588243
RGD:9588244
G Taf1c TATA-box binding protein associated factor, RNA polymerase 1 subunit C JBrowse link 19 52,246,061 52,252,642 RGD:9588243
RGD:9588244
G Taf1d TATA-box binding protein associated factor, RNA polymerase I subunit D JBrowse link 8 13,861,242 13,871,508 RGD:9588243
RGD:9588244
G Tbp TATA box binding protein JBrowse link 1 57,491,381 57,509,335 RGD:9588243
RGD:9588244
G Ttf1 transcription termination factor 1 JBrowse link 3 7,635,630 7,660,153 RGD:9588249
G Twistnb TWIST neighbor JBrowse link 6 52,751,106 52,768,574 RGD:9588244
RGD:9588262
G Ubtf upstream binding transcription factor, RNA polymerase I JBrowse link 10 90,250,275 90,265,772 RGD:9588243
RGD:9588244
G Wdr61 WD repeat domain 61 JBrowse link 8 59,296,339 59,313,663 RGD:9588246
G Znrd1 zinc ribbon domain containing 1 JBrowse link 20 2,088,518 2,092,436 RGD:9588244
RGD:9588262

Pathway Gene Annotations

Disease Annotations Associated with Genes in the RNA polymerase I transcription pathway
Disease TermsGene Symbols
Abnormalities, MultipleCrebbp
ACROFACIAL DYSOSTOSIS, CINCINNATI TYPEPolr1a
Acute Kidney InjurySirt1
Adenocarcinoma of LungCrebbp , Ttf1
ADENOCARCINOMA OF STOMACHCrebbp
Alzheimer DiseaseCrebbp , Sirt1 , Tbp
Amyotrophic Lateral SclerosisSirt1
Amyotrophic Lateral Sclerosis 1Crebbp
Arsenic PoisoningTaf1d
AtherosclerosisSirt1
Attention Deficit Disorder with HyperactivityCrebbp
Autistic DisorderTaf1c
Autoimmune DiseasesSirt1
Binge DrinkingSirt1
Brain InfarctionSirt1
Brain InjuriesSirt1
Brain NeoplasmsSirt1
Breast NeoplasmsSirt1
Carcinoma, Adenoid CysticCrebbp
Carcinoma, HepatocellularCrebbp
Carcinoma, Squamous CellCrebbp
Carcinoma, Squamous Cell of Head and NeckCrebbp
Carcinoma, Transitional CellCrebbp
CardiomegalyUbtf
Carotid AtherosclerosisSirt1
Ceroid Lipofuscinosis, Neuronal 1, InfantileSirt1
ChoreaTtf1
Choreoathetosis, Hypothyroidism, and Neonatal Respiratory DistressTtf1
Ciliary Dyskinesia, Primary, 13Taf1c
Ciliary Dyskinesia, Primary, 28Polr2k
ColitisSirt1
Colorectal NeoplasmsCrebbp
Demyelinating DiseasesSirt1
Diabetes MellitusCavin1 , Sirt1
Diabetes Mellitus, ExperimentalSirt1
Diabetes Mellitus, Type 1Tbp
Diabetes Mellitus, Type 2Sirt1
Diabetic RetinopathySirt1
Encephalomyelitis, Autoimmune, ExperimentalSirt1
EpilepsySirt1
Erectile DysfunctionSirt1
Esophageal Squamous Cell CarcinomaCrebbp
Fatty LiverSirt1 , Sirt7
Fibroma, OssifyingCdc73
FibrosisSirt1
Genetic Diseases, InbornCrebbp
Genomic InstabilitySirt1
GlaucomaCrebbp
GlioblastomaCrebbp
Glucose IntoleranceSirt1
Heart DiseasesSirt1
Heart FailureSirt1
Hirschsprung Disease 1Crebbp , Polr2f
HIV InfectionsSirt1
Huntington DiseaseSirt1 , Tbp
HyperparathyroidismCdc73
Hyperparathyroidism 1Cdc73
Hyperparathyroidism 2Cdc73
HypertrophySirt1
Hypertrophy, Left VentricularNcl , Sirt1
Infarction, Middle Cerebral ArterySirt1
Insulin ResistanceSirt1
Kartagener SyndromePolr2k , Taf1c
Kidney Reperfusion InjurySirt1
Leukemia, Myeloid, AcuteCrebbp
LEUKODYSTROPHY, HYPOMYELINATING, 11Polr1c
Lipodystrophy, Congenital Generalized, Type 4Cavin1
Lipodystrophy, Familial PartialCavin1
Liver Cirrhosis, ExperimentalSirt1
Liver InjurySirt1
Liver NeoplasmsCrebbp
Liver Reperfusion InjurySirt1
Lung InjurySirt1
Lymphoma, FollicularCrebbp
Macular DegenerationSirt1
Mandibulofacial DysostosisPolr1c
Mandibulofacial Dysostosis, Treacher Collins Type, Autosomal RecessivePolr1c
MedulloblastomaCrebbp
MelanomaCrebbp
Metabolic Syndrome XSirt1
Methylmalonic AcidemiaCavin1
Myocardial InfarctionSirt1
Myocardial IschemiaNcl
Myocardial Reperfusion InjuryNcl , Sirt1
Myocarditis, Autoimmune, ExperimentalSirt1
Neoplasms, ExperimentalZnrd1
Nerve DegenerationSirt1
Neurodegenerative DiseasesSirt1
Non-alcoholic Fatty Liver DiseaseSirt1
ObesitySirt1
OsteoporosisSirt1
ParalysisSirt1
Parathyroid Adenomatosis, Familial CysticCdc73
Parathyroid NeoplasmsCdc73
Parkinson Disease, Late-OnsetTbp
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, and Hirschsprung DiseasePolr2f
Peroxisome Biogenesis Disorder 5A (Zellweger)Paf1
Peroxisome Biogenesis Disorder 5BPaf1
Peroxisome Biogenesis DisordersPaf1
Pleomorphic Xanthoastrocytoma Twistnb
PneumoniaSirt1
Pneumonia, PneumococcalSirt1
Precursor Cell Lymphoblastic Leukemia-LymphomaCrebbp
Prostatic NeoplasmsCrebbp , Sirt1
Retinal DiseasesSirt1
Rubinstein-Taybi SyndromeCrebbp
SchizophreniaRrn3 , Tbp
Scleroderma, SystemicSirt1 , Sirt7
ScoliosisCrebbp
Senile CataractSirt1
Sezary SyndromeCrebbp
Shock, HemorrhagicSirt1
Skin DiseasesTaf1d
Sleep Apnea SyndromesTbp
Small Cell Lung CarcinomaCrebbp
Smith-Magenis SyndromeCavin1 , Sirt7 , Supt4h1 , Ubtf
Spinal Cord InjuriesTbp
Spinocerebellar Ataxia 17Tbp
Spinocerebellar AtaxiasTbp
Squamous Cell Carcinoma of the LungCrebbp
Stomach NeoplasmsZnrd1
ThrombosisSirt1
Thumb DeformityCrebbp
Thyroid Carcinoma, Nonmedullary 1Ttf1
Urinary Bladder NeoplasmsCrebbp
Uterine Cervical NeoplasmsCrebbp
Waardenburg SyndromePolr2f
Waardenburg Syndrome Type 2Polr2f
Waardenburg Syndrome, Type 4CPolr2f
Wallerian DegenerationSirt1
Weight GainCavin1
Pathway Annotations Associated with Genes in the RNA polymerase I transcription pathway
Pathway TermsGene Symbols
aldosterone signaling pathwayCrebbp
androgen signaling pathwayCrebbp
cell cycle pathway, mitoticCrebbp
cisplatin drug pathwaySsrp1 , Tbp , Ubtf
cortisol signaling pathwayCrebbp
estrogen signaling pathwayCrebbp
forkhead class A signaling pathwayCrebbp
Hedgehog signaling pathwayCrebbp
histone modification pathwayCrebbp , Sirt1 , Sirt7 , Ssrp1 , Supt16h
Huntington disease pathwayCrebbp , Polr2e , Polr2f , Tbp
hypoxia inducible factor pathwayCrebbp
influenza A virus infection pathwayCrebbp
Jak-Stat signaling pathwayCrebbp
long term potentiationCrebbp
mTOR signaling pathwayRrn3
Mycobacterium tuberculosis infection pathwayCrebbp
Notch signaling pathwayCrebbp
nuclear factor, erythroid 2 like 2 signaling pathwayCrebbp
nucleotide excision repair pathwayPolr1a
p53 signaling pathwayCrebbp , Sirt1
prostate cancer pathwayCrebbp
purine metabolic pathwayPolr1a , Polr1b , Polr1c , Polr1e , Polr2e , Polr2f , Znrd1
pyrimidine metabolic pathwayPolr1a , Polr1b , Polr1c , Polr1e , Polr2e , Polr2f , Znrd1
renal cell cancer pathwayCrebbp
RNA degradation pathwayWdr61
RNA polymerase I transcription pathwayCavin1 , Cd3eap , Cdc73 , Crebbp , Ctr9 , Leo1 , Ncl , Paf1 , Polr1a , Polr1b , Polr1c , Polr1e , Polr2e , Polr2f , Polr2k , Rrn3 , Rtf1 , Sirt1 , Sirt7 , Ssrp1 , Supt16h , Supt4h1 , Supt5h , Taf12 , Taf1a , Taf1b , Taf1c , Taf1d , Tbp , Ttf1 , Twistnb , Ubtf , Wdr61 , Znrd1
RNA polymerase II transcription elongation pathwayCdc73 , Ctr9 , Leo1 , Paf1 , Rtf1 , Ssrp1 , Supt16h , Supt4h1 , Supt5h , Wdr61
RNA polymerase II transcription initiation pathwayTaf12 , Tbp
RNA polymerase II transcription pathwayPolr2e , Polr2f , Polr2k
RNA polymerase III transcription pathwayPolr1c , Polr2e , Polr2f , Polr2k , Tbp
Sirtuin mediated pathwaySirt1 , Sirt7
transforming growth factor-beta Smad dependent signaling pathwayCrebbp
transforming growth factor-beta superfamily mediated signaling pathwayCrebbp
type II interferon signaling pathwayCrebbp
Wnt signaling pathwayCrebbp
Wnt signaling, canonical pathwayCrebbp
Phenotype Annotations Associated with Genes in the RNA polymerase I transcription pathway
Phenotype TermsGene Symbols
cardiac hypertrophyCrebbp

References Associated with the RNA polymerase I transcription pathway:

Ontology Path Diagram:

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