Bglap (bone gamma-carboxyglutamate protein) - Rat Genome Database

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Gene: Bglap (bone gamma-carboxyglutamate protein) Rattus norvegicus
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Symbol: Bglap
Name: bone gamma-carboxyglutamate protein
RGD ID: 2206
Description: A structural constituent of bone. Involved in several processes, including cellular response to vitamin D; cellular response to zinc ion starvation; and response to hydroxyisoflavone. Located in several cellular components, including dendrite; extracellular space; and perikaryon. Used to study congenital hypothyroidism and osteoporosis. Biomarker of autosomal dominant hypocalcemia; end stage renal disease; osteoporosis; polycystic kidney disease; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in osteoarthritis; osteoporosis; prostate cancer; rheumatoid arthritis; and vitamin K deficiency bleeding. Orthologous to human BGLAP (bone gamma-carboxyglutamate protein); PARTICIPATES IN fibroblast growth factor signaling pathway; INTERACTS WITH (20S)-ginsenoside Rg3; (S)-nicotine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bglap2; Bgp; BGPR; BGPRA; bone gamma-carboxyglutamate (gla) protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin); bone gamma-carboxyglutamate protein 2; bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin); bone Gla protein; bone Gla-protein; gamma-carboxyglutamic acid-containing protein; osteocalcin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,136,341 - 176,137,318 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2176,136,341 - 176,137,318 (-)EnsemblGRCr8
mRatBN7.22173,838,518 - 173,839,495 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,838,518 - 173,839,495 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2180,982,788 - 180,983,765 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,005,149 - 179,006,126 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,605,147 - 173,606,124 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,741,770 - 187,748,445 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,741,770 - 187,742,747 (-)Ensemblrn6Rnor6.0
Rnor_5.02207,144,494 - 207,150,926 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42180,482,313 - 180,483,290 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2167,783,260 - 167,784,237 (-)NCBICelera
RGSC_v3.12180,432,418 - 180,433,396 (-)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rg3  (EXP)
(S)-nicotine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bisphospho-D-glyceric acid  (ISO)
2,3-bisphosphoglyceric acid  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3'-O-(4-Benzoyl)benzoyl ATP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-aminobenzamide  (ISO)
4',5,7-trihydroxy-3'-methoxyflavone  (ISO)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (EXP)
5-formyltetrahydrofolic acid  (EXP)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
9-cis-retinoic acid  (ISO)
acrylamide  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
allopurinol  (EXP)
alloxanthine  (EXP)
aluminium atom  (EXP,ISO)
aluminium oxide  (ISO)
aluminium(0)  (EXP,ISO)
ammonium chloride  (EXP,ISO)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimycin A  (ISO)
apocynin  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (EXP)
atorvastatin calcium  (ISO)
aucubin  (EXP,ISO)
azadirachtin A  (ISO)
bafilomycin A1  (ISO)
beclomethasone  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
beta-D-glucosamine  (ISO)
bexarotene  (ISO)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
Bisphenol A diglycidyl ether  (EXP,ISO)
boron atom  (ISO)
budesonide  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caesium atom  (EXP)
caffeine  (EXP)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium carbonate  (ISO)
calcium dichloride  (ISO)
cannabidiol  (ISO)
CHIR 99021  (ISO)
chitosan  (ISO)
chlormequat chloride  (EXP)
chloroquine  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (EXP)
cycloheximide  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP)
disulfiram  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP)
elemental boron  (ISO)
enalapril  (EXP)
enzacamene  (EXP)
ethanol  (EXP,ISO)
ethylparaben  (ISO)
Falecalcitriol  (ISO)
fasudil  (ISO)
fentin hydroxide  (ISO)
flavonoids  (EXP)
fluticasone  (ISO)
fulvestrant  (EXP,ISO)
gamma-aminobutyric acid  (EXP)
gamma-Oryzanol (TN)  (EXP)
Ganoderic acid A  (EXP)
genistein  (ISO)
glucose  (EXP,ISO)
glycerol 2-phosphate  (EXP,ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
Goserelin  (ISO)
Harpagoside  (ISO)
hemin  (EXP)
hexadecanoic acid  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
icariin  (EXP,ISO)
icariside II  (EXP)
Icaritin  (EXP)
ifosfamide  (ISO)
ionomycin  (ISO)
iron dextran  (EXP)
isonicotinamide  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP)
lithium chloride  (ISO)
lithocholic acid  (ISO)
LY294002  (ISO)
magnesium atom  (ISO)
melatonin  (EXP,ISO)
menadione  (ISO)
menaquinone  (EXP,ISO)
menaquinone-4  (ISO)
menaquinone-7  (ISO)
methotrexate  (EXP)
methylparaben  (ISO)
microcystin-LR  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
montelukast  (ISO)
Morroniside  (EXP)
myricitrin  (ISO)
N(4)-hydroxycytidine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (ISO)
naringin  (EXP,ISO)
nebivolol  (EXP)
neoeriocitrin  (ISO)
neohesperidin  (ISO)
nicotine  (EXP,ISO)
nitric acid  (EXP)
NMN zwitterion  (EXP,ISO)
norethisterone  (ISO)
notoginsenoside R1  (ISO)
ormeloxifene  (EXP)
oxaliplatin  (EXP)
pamidronate  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
Phenylamil  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
phylloquinone  (ISO)
pioglitazone  (ISO)
poly(ethylene)  (ISO)
prallethrin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (EXP,ISO)
quinoxyfen  (ISO)
raloxifene  (ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
rutin  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
sciadopitysin  (ISO)
sclareol  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP,ISO)
streptozocin  (EXP,ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP)
Theaflavin 3,3'-digallate  (ISO)
titanium atom  (EXP)
topotecan  (EXP)
tributylstannane  (ISO)
troglitazone  (EXP)
tubocurarine  (ISO)
tungsten  (ISO)
uranium atom  (EXP,ISO)
valproic acid  (ISO)
vitamin D  (ISO)
vitamin E  (EXP)
vitamin K  (EXP)
vorinostat  (ISO)
warfarin  (EXP,ISO)
XAV939  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc protoporphyrin  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell projection  (IDA)
cytoplasm  (IEA,ISO)
dendrite  (IDA)
extracellular matrix  (ISO)
extracellular region  (IBA,IDA,IEA,ISO,TAS)
extracellular space  (IDA,IEA)
perikaryon  (IDA)
vesicle  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Bone metabolism in male patients with type 2 diabetes. Achemlal L, etal., Clin Rheumatol. 2005 Sep;24(5):493-6. Epub 2005 Mar 4.
2. Biochemical determinants of severe lithogenic activity in patients with idiopathic calcium nephrolithiasis. Arrabal-Polo MA, etal., Urology. 2012 Jan;79(1):48-54. doi: 10.1016/j.urology.2011.07.1382. Epub 2011 Sep 9.
3. A twist code determines the onset of osteoblast differentiation. Bialek P, etal., Dev Cell. 2004 Mar;6(3):423-35.
4. Interest of biochemical markers of bone turnover for long-term prediction of new vertebral fracture in postmenopausal osteoporotic women. Bruyere O, etal., Maturitas. 2003 Apr 25;44(4):259-65.
5. Binge alcohol-induced bone damage is accompanied by differential expression of bone remodeling-related genes in rat vertebral bone. Callaci JJ, etal., Calcif Tissue Int. 2009 Jun;84(6):474-84. Epub 2009 Mar 28.
6. Immunocytochemical localization of gamma-carboxyglutamic acid-containing proteins (osteocalcin) in rat bone and dentin. Camarda AJ, etal., Calcif Tissue Int. 1987 Jun;40(6):349-55.
7. Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. Celeste AJ, etal., EMBO J 1986 Aug;5(8):1885-90.
8. Comparative study of quantitative ultrasonography and dual-energy X-ray absorptiometry for evaluating renal osteodystrophy in children with chronic kidney disease. Christoforidis A, etal., J Bone Miner Metab. 2011 May;29(3):321-7. doi: 10.1007/s00774-010-0220-1. Epub 2010 Sep 16.
9. Evidences for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats. El-Shitany NA, etal., Phytomedicine. 2009 Jul 2.
10. 1,25-Dihydroxyvitamin D3 stimulates the synthesis of matrix gamma-carboxyglutamic acid protein by osteosarcoma cells. Mutually exclusive expression of vitamin K-dependent bone proteins by clonal osteoblastic cell lines. Fraser JD, etal., J Biol Chem. 1988 Jan 15;263(2):911-6.
11. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology Gao Y, etal., Hua Xi Kou Qiang Yi Xue Za Zhi. 2009 Apr;27(2):213-6.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Increased levels of osteocalcin (serum bone Gla-protein) in rheumatoid arthritis. Gevers G, etal., Br J Rheumatol. 1986 Aug;25(3):260-2.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Ultrastructural localization of osteocalcin in rat tooth germs by immunogold staining. Gorter de Vries I, etal., Histochemistry. 1988;89(5):509-14.
16. Immunocytochemical localization of osteocalcin in developing rat teeth. Gorter de Vries I, etal., J Dent Res. 1987 Mar;66(3):784-90.
17. Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes. Hie M and Tsukamoto I, Int J Mol Med. 2010 Oct;26(4):611-8. doi: 10.3892/ijmm_00000506.
18. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
19. Impaired gamma carboxylation of osteocalcin in elderly women with type II diabetes mellitus: relationship between increase in undercarboxylated osteocalcin levels and low bone mineral density. Horiuchi T, etal., J Bone Miner Metab. 2004;22(3):236-40.
20. Formononetin promotes early fracture healing through stimulating angiogenesis by up-regulating VEGFR-2/Flk-1 in a rat fracture model. Huh JE, etal., Int Immunopharmacol. 2009 Nov;9(12):1357-65. Epub 2009 Aug 17.
21. Ethanol increases osteoclastogenesis associated with the increased expression of RANK, PU.1 and MITF in vitro and in vivo. Iitsuka N, etal., Int J Mol Med. 2012 Jul;30(1):165-72. doi: 10.3892/ijmm.2012.974. Epub 2012 Apr 20.
22. Alterations in serum levels of 1 alpha,25(OH)2 D3 and osteocalcin in patients with early diabetic nephropathy. Inukai T, etal., Diabetes Res Clin Pract. 1997 Oct;38(1):53-9.
23. Radiographic hand osteoarthritis and serum levels of osteocalcin: cross-sectional study. Kalichman L and Kobyliansky E, Rheumatol Int. 2010 Jun;30(8):1131-5. Epub 2010 Feb 16.
24. Serum osteocalcin/bone-specific alkaline phosphatase ratio is a predictor for the presence of vertebral fractures in men with type 2 diabetes. Kanazawa I, etal., Calcif Tissue Int. 2009 Sep;85(3):228-34. doi: 10.1007/s00223-009-9272-4. Epub 2009 Jul 30.
25. Tacrolimus treatment increases bone formation in patients with rheumatoid arthritis. Kang KY, etal., Rheumatol Int. 2012 Mar 25.
26. Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markers. Karaoz E, etal., Histochem Cell Biol. 2009 Nov;132(5):533-46. Epub 2009 Aug 14.
27. Regulation of osteogenic differentiation of rat bone marrow stromal cells on 2D nanorod substrates. Kaur G, etal., Biomaterials. 2009 Dec 18.
28. Equal BMD after daily or triweekly exercise in growing rats. Kayser BD, etal., Int J Sports Med. 2010 Jan;31(1):44-50. Epub 2009 Dec 22.
29. Small intestine submucosa sponge for in vivo support of tissue-engineered bone formation in the presence of rat bone marrow stem cells. Kim KS, etal., Biomaterials. 2009 Oct 23.
30. The expression of molecular mediators in the idiopathic cutaneous calcification and ossification. Kim SY, etal., J Cutan Pathol. 2008 Sep;35(9):826-31. doi: 10.1111/j.1600-0560.2007.00904.x. Epub 2008 Apr 18.
31. Does exercise modify the effects of zoledronic acid on bone mass, microarchitecture, biomechanics, and turnover in ovariectomized rats? Lespessailles E, etal., Calcif Tissue Int. 2009 Aug;85(2):146-57. Epub 2009 Jul 17.
32. [Serum osteoprotegerin level in children with nephrotic syndrome and the effect of glucocorticoid on it]. Li YL and Wang H, Zhongguo Dang Dai Er Ke Za Zhi. 2012 Sep;14(9):653-6.
33. Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression. Lian J, etal., Proc Natl Acad Sci U S A 1989 Feb;86(4):1143-7.
34. Upregulation of heme oxygenase-1 inhibits the maturation and mineralization of osteoblasts. Lin TH, etal., J Cell Physiol. 2010 Mar;222(3):757-68.
35. Effect of age and extrinsic microenvironment on the proliferation and osteogenic differentiation of rat dental pulp stem cells in vitro. Ma D, etal., J Endod. 2009 Nov;35(11):1546-53. Epub 2009 Sep 20.
36. Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease. Maicas N, etal., Antioxid Redox Signal. 2011 Aug 15;15(4):889-901. Epub 2011 May 25.
37. Dietary protein supplementation increases peak bone mass acquisition in energy-restricted growing rats. Mardon J, etal., Pediatr Res. 2009 Nov;66(5):513-8.
38. Bone metabolic abnormalities associated with well-controlled type 1 diabetes (IDDM) in young adult women: a disease complication often ignored or neglected. Masse PG, etal., J Am Coll Nutr. 2010 Aug;29(4):419-29.
39. Effects of vitamin K on the morphometric and material properties of bone in the tibiae of growing rats. Matsumoto T, etal., Metabolism. 2012 Mar;61(3):407-14. Epub 2011 Sep 23.
40. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
41. A 2-year follow-up study on bone mineral density and markers of bone turnover in patients with long-standing insulin-dependent diabetes mellitus. Miazgowski T and Czekalski S, Osteoporos Int. 1998;8(5):399-403.
42. Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins. Nahar NN, etal., J Bone Miner Metab. 2008;26(5):514-9. Epub 2008 Aug 30.
43. Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis. Naito K, etal., Int J Mol Med. 2012 May;29(5):756-60. doi: 10.3892/ijmm.2012.897. Epub 2012 Jan 26.
44. Fibroblast growth factor-2 induces osteogenic differentiation through a Runx2 activation in vascular smooth muscle cells. Nakahara T, etal., Biochem Biophys Res Commun. 2009 Nov 11.
45. Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease. Nakajima S, etal., Nutrition. 2011 Oct;27(10):1023-8. Epub 2011 Apr 9.
46. Discriminants of prevalent fractures in chronic kidney disease. Nickolas TL, etal., J Am Soc Nephrol. 2011 Aug;22(8):1560-72. doi: 10.1681/ASN.2010121275. Epub 2011 Jul 22.
47. The effect of vitamin K supplementation on biochemical markers of bone formation in children and adolescents with cystic fibrosis. Nicolaidou P, etal., Eur J Pediatr. 2006 Aug;165(8):540-5. Epub 2006 Apr 19.
48. The effect of aging on bone formation in rats: biochemical and histological evidence for decreased bone formation capacity. Nishimoto SK, etal., Calcif Tissue Int. 1985 Dec;37(6):617-24.
49. Undercarboxylated osteocalcin is a biomarker of carotid calcification in patients with essential hypertension. Okura T, etal., Kidney Blood Press Res. 2010;33(1):66-71. Epub 2010 Mar 2.
50. Bone cells from patients with quiescent Crohn's disease show a reduced growth potential and an impeded maturation. Oostlander AE, etal., J Cell Biochem. 2012 Jul;113(7):2424-2431. doi: 10.1002/jcb.24119.
51. Role of dietary phosphorus and degree of uremia in the development of renal bone disease in rats. Oste L, etal., Ren Fail. 2007;29(1):1-12.
52. Developmental appearance of matrix GLA protein during calcification in the rat. Otawara Y and Price PA, J Biol Chem. 1986 Aug 15;261(23):10828-32.
53. A novel Phex mutation in a new mouse model of hypophosphatemic rickets. Owen C, etal., J Cell Biochem. 2012 Jul;113(7):2432-41. doi: 10.1002/jcb.24115.
54. The propeptide of rat bone gamma-carboxyglutamic acid protein shares homology with other vitamin K-dependent protein precursors. Pan LC and Price PA, Proc Natl Acad Sci U S A 1985 Sep;82(18):6109-13.
55. Interaction of the 1alpha,25-dihydroxyvitamin D3 receptor at the distal promoter region of the bone-specific osteocalcin gene requires nucleosomal remodelling. Paredes R, etal., Biochem J 2002 May 1;363(Pt 3):667-76.
56. Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells. Paredes R, etal., Mol Cell Biol. 2004 Oct;24(20):8847-61.
57. L-arginine supplementation normalizes bone turnover and preserves bone mass in streptozotocin-induced diabetic rats. Pennisi P, etal., J Endocrinol Invest. 2009 Jun;32(6):546-51. Epub 2009 May 5.
58. Bone mineral metabolism in patients with neurofibromatosis type 1 (von Recklingausen disease). Petramala L, etal., Arch Dermatol Res. 2012 May;304(4):325-31. Epub 2011 Nov 27.
59. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
60. Impairment of bone status in patients with central diabetes insipidus. Pivonello R, etal., J Clin Endocrinol Metab. 1998 Jul;83(7):2275-80.
61. Synergistic role of hydroxyapatite nanoparticles and pulsed electromagnetic field therapy to prevent bone loss in rats following exposure to simulated microgravity. Prakash D and Behari J, Int J Nanomedicine. 2009;4:133-44. Epub 2009 Sep 10.
62. 1,25-Dihydroxyvitamin D3 increases citrate secretion from osteosarcoma cells. Price PA, etal., J Biol Chem. 1984 Feb 25;259(4):2537-40.
63. Orchiectomy upregulates free soluble RANKL in bone marrow of aged rats. Proell V, etal., Bone. 2009 Oct;45(4):677-81. Epub 2009 Jun 6.
64. Icariin Prevents Diabetes-Induced Bone Loss in Rats by Reducing Blood Glucose and Suppressing Bone Turnover. Qi S, etal., Molecules. 2019 May 15;24(10):1871. doi: 10.3390/molecules24101871.
65. GOA pipeline RGD automated data pipeline
66. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
67. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
68. Zinc deficiency reduces bone mineral density in the spine of young adult rats: a pilot study. Ryz NR, etal., Ann Nutr Metab. 2009;54(3):218-26. Epub 2009 Jun 9.
69. Is vitamin D status a determining factor for metabolic syndrome? A case-control study. Salekzamani S, etal., Diabetes Metab Syndr Obes. 2011;4:205-12. Epub 2011 Jun 10.
70. Abnormal bone and calcium metabolism in immobilized Parkinson's disease patients. Sato Y, etal., Mov Disord. 2005 Dec;20(12):1598-603.
71. Histone acetylation in vivo at the osteocalcin locus is functionally linked to vitamin D-dependent, bone tissue-specific transcription. Shen J, etal., J Biol Chem 2002 Jun 7;277(23):20284-92.
72. The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover. Silva IV, etal., J Bone Miner Res. 2003 Apr;18(4):615-23.
73. Serum concentration of undercarboxylated osteocalcin and the risk of osteoporosis in thai elderly women. Soontrapa S, etal., J Med Assoc Thai. 2005 Oct;88 Suppl 5:S29-32.
74. Transcriptional repression of the rat osteocalcin gene by deltaEF1. Sooy K and Demay MB, Endocrinology 2002 Sep;143(9):3370-5.
75. Osteocalcin- and Osteopontin-Containing Neurons in the Rat Hind Brain. Suzuki T, etal., Cell Mol Neurobiol. 2012 May 3.
76. Studies on gene expression in calvaria and serum levels of insulin-like growth factor-I and bone Gla protein in the methimazole-induced congenital hypothyroid rat. Takeuchi H, etal., Endocr J. 1993 Jun;40(3):351-62.
77. Molecular structure of the rat bone Gla protein gene and identification of putative regulatory elements. Theofan G, etal., DNA 1989 Apr;8(3):213-21.
78. The response of circulating parameters of bone mineral metabolism to ethanol- and EDTA-induced hypocalcemia in the rat. Thomas S, etal., Bone Miner. 1990 Jan;8(1):1-6.
79. Association between osteoporosis and polymorphisms of the bone Gla protein, estrogen receptor 1, collagen 1-A1 and calcitonin receptor genes in Turkish postmenopausal women. Tural S, etal., Gene. 2013 Feb 15;515(1):167-72. doi: 10.1016/j.gene.2012.10.041. Epub 2012 Nov 5.
80. Extracorporeal shockwave therapy shows chondroprotective effects in osteoarthritic rat knee. Wang CJ, etal., Arch Orthop Trauma Surg. 2011 Aug;131(8):1153-8. Epub 2011 Mar 9.
81. Elevated bone turnover in rat polycystic kidney disease is not due to prostaglandin E2. Weiler H, etal., Pediatr Nephrol. 2002 Oct;17(10):795-9. Epub 2002 Aug 10.
82. The dichotomy in the effects of 1,25 dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 on bone gamma-carboxyglutamic acid-containing protein in serum and bone in vitamin D-deficient rats. Wientroub S, etal., Calcif Tissue Int. 1987 Mar;40(3):166-72.
83. Administration of colony stimulating factor-1 to toothless osteopetrotic rats normalizes osteoblast, but not osteoclast, gene expression. Wisner-Lynch LA, etal., Bone. 1995 Jun;16(6):611-8. doi: 10.1016/8756-3282(95)00114-s.
84. Osteocalcin gene HindIII C/T polymorphism is a biomarker for prostate cancer and responsiveness to hormone therapy. Wu HC, etal., Eur Urol. 2003 Feb;43(2):197-200.
85. Icariin Restores Bone Structure and Strength in a Rat Model of Chronic High-Dose Alcohol-Induced Osteopenia. Wu JZ, etal., Cell Physiol Biochem. 2018;46(4):1727-1736. doi: 10.1159/000489248. Epub 2018 Apr 23.
86. Elevation of PTH and PTHrp Induced by Excessive Fluoride in Rats on a Calcium-deficient Diet. Xu H, etal., Biol Trace Elem Res. 2009 Nov 14.
87. Effects of BMP-2 and dexamethasone on osteogenic differentiation of rat dental follicle progenitor cells seeded on three-dimensional beta-TCP. Xu LL, etal., Biomed Mater. 2009 Dec;4(6):65010. Epub .
88. Characterization of the rat osteocalcin gene: stimulation of promoter activity by 1,25-dihydroxyvitamin D3. Yoon KG, etal., Biochemistry 1988 Nov 15;27(23):8521-6.
89. Protective effects of Polygonatum sibiricum polysaccharide on ovariectomy-induced bone loss in rats. Zeng GF, etal., J Ethnopharmacol. 2011 Jun 14;136(1):224-9. Epub 2011 Apr 28.
Additional References at PubMed
PMID:8101026   PMID:8218200   PMID:11856645   PMID:12554783   PMID:12647294   PMID:12960019   PMID:15456894   PMID:15485875   PMID:15621021   PMID:16443258   PMID:16772287   PMID:17023519  
PMID:17218095   PMID:17786964   PMID:17968486   PMID:18171674   PMID:19191495   PMID:19670267   PMID:21302441   PMID:21324897   PMID:21757657   PMID:21820092   PMID:22405968   PMID:22999414  
PMID:23817840   PMID:24391920   PMID:24554534   PMID:25185647   PMID:27291707   PMID:27483347   PMID:27488359   PMID:27746193   PMID:31533469   PMID:32556013  


Genomics

Comparative Map Data
Bglap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,136,341 - 176,137,318 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2176,136,341 - 176,137,318 (-)EnsemblGRCr8
mRatBN7.22173,838,518 - 173,839,495 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,838,518 - 173,839,495 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2180,982,788 - 180,983,765 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,005,149 - 179,006,126 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,605,147 - 173,606,124 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,741,770 - 187,748,445 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,741,770 - 187,742,747 (-)Ensemblrn6Rnor6.0
Rnor_5.02207,144,494 - 207,150,926 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42180,482,313 - 180,483,290 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2167,783,260 - 167,784,237 (-)NCBICelera
RGSC_v3.12180,432,418 - 180,433,396 (-)NCBI
Cytogenetic Map2q34NCBI
BGLAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,242,184 - 156,243,317 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,242,184 - 156,243,317 (+)Ensemblhg38GRCh38
GRCh371156,211,975 - 156,213,108 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,478,629 - 154,479,736 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341153,025,077 - 153,026,185NCBI
Celera1129,284,933 - 129,286,094 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,573,050 - 127,574,222 (+)NCBIHuRef
CHM1_11157,607,924 - 157,609,096 (+)NCBICHM1_1
T2T-CHM13v2.01155,380,641 - 155,381,774 (+)NCBIT2T-CHM13v2.0
Bglap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,290,802 - 88,291,773 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,290,808 - 88,291,771 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38388,383,495 - 88,384,466 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,383,501 - 88,384,464 (-)Ensemblmm10GRCm38
MGSCv37388,187,417 - 88,188,386 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36388,469,422 - 88,470,391 (-)NCBIMGSCv36mm8
Celera388,423,135 - 88,424,104 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.82NCBI
Bglap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,381,156 - 2,381,978 (+)Ensembl
ChiLan1.0NW_0049555452,381,091 - 2,382,114 (+)NCBIChiLan1.0ChiLan1.0
BGLAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,602,088 - 93,605,108 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,333,985 - 93,337,006 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,583,789 - 131,586,459 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,413,871 - 135,416,432 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,413,871 - 135,416,432 (+)EnsemblpanPan2panpan1.1
BGLAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,630,092 - 41,630,976 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,630,098 - 41,665,791 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha741,117,871 - 41,118,763 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0741,494,521 - 41,495,418 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,494,525 - 41,516,608 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,275,834 - 41,276,717 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,329,023 - 41,329,894 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,613,117 - 41,614,007 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bglap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,449,368 - 26,451,906 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,481,355 - 5,482,155 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,480,023 - 5,482,288 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BGLAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,623,716 - 7,626,353 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,623,883 - 7,624,812 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660386,916,245 - 6,918,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bglap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,527,538 - 1,528,109 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248851,526,625 - 1,528,235 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bglap
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1365,181,043 - 65,181,965 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:83
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000026530
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2145807215190807215Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
10043139Iddm55Insulin dependent diabetes mellitus QTL 553.10.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2150313808195313808Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085178247591Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837178247591Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2143565208188565208Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2154723085178247591Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085178247591Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2139067258192287892Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2159440760195313808Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2139067258184067258Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085178247591Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085178247591Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150096616195096616Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2154723085178247591Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2147287892192287892Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150096616195096616Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2175279960178247591Rat

Markers in Region
PMC151127P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,838,664 - 173,839,446 (+)MAPPERmRatBN7.2
Rnor_6.02187,741,918 - 187,742,699NCBIRnor6.0
Rnor_5.02207,144,861 - 207,145,642UniSTSRnor5.0
RGSC_v3.42180,482,460 - 180,483,241UniSTSRGSC3.4
Celera2167,783,407 - 167,784,188UniSTS
Cytogenetic Map2q34UniSTS
PMC34552P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,838,538 - 173,839,436 (+)MAPPERmRatBN7.2
Rnor_6.02187,741,792 - 187,742,689NCBIRnor6.0
Rnor_5.02207,144,735 - 207,145,632UniSTSRnor5.0
RGSC_v3.42180,482,334 - 180,483,231UniSTSRGSC3.4
Celera2167,783,281 - 167,784,178UniSTS
Cytogenetic Map2q34UniSTS
RH132274  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,838,177 - 173,838,368 (+)MAPPERmRatBN7.2
Rnor_6.02187,741,431 - 187,741,621NCBIRnor6.0
Rnor_5.02207,144,374 - 207,144,564UniSTSRnor5.0
RGSC_v3.42180,481,973 - 180,482,163UniSTSRGSC3.4
Celera2167,782,920 - 167,783,110UniSTS
RH 3.4 Map21148.9UniSTS
Cytogenetic Map2q34UniSTS
PMC34552P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,838,538 - 173,839,031 (+)MAPPERmRatBN7.2
Rnor_6.02187,741,792 - 187,742,284NCBIRnor6.0
Rnor_5.02207,144,735 - 207,145,227UniSTSRnor5.0
RGSC_v3.42180,482,334 - 180,482,826UniSTSRGSC3.4
Celera2167,783,281 - 167,783,773UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 9 57 129 78 77 46 86 46 6 285 170 11 104 51 70 31 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000026530   ⟹   ENSRNOP00000026530
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2176,136,341 - 176,137,318 (-)Ensembl
mRatBN7.2 Ensembl2173,838,518 - 173,839,495 (-)Ensembl
Rnor_6.0 Ensembl2187,741,770 - 187,742,747 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000108765   ⟹   ENSRNOP00000093694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2176,136,341 - 176,137,269 (-)Ensembl
mRatBN7.2 Ensembl2173,838,518 - 173,839,446 (-)Ensembl
RefSeq Acc Id: NM_013414   ⟹   NP_038200
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,136,341 - 176,137,318 (-)NCBI
mRatBN7.22173,838,518 - 173,839,495 (-)NCBI
Rnor_6.02187,741,771 - 187,742,748 (-)NCBI
Rnor_5.02207,144,494 - 207,150,926 (-)NCBI
RGSC_v3.42180,482,313 - 180,483,290 (-)RGD
Celera2167,783,260 - 167,784,237 (-)RGD
Sequence:
RefSeq Acc Id: NP_038200   ⟸   NM_013414
- Peptide Label: preproprotein
- UniProtKB: P04640 (UniProtKB/Swiss-Prot),   A6J671 (UniProtKB/TrEMBL),   A0A8I6AK32 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026530   ⟸   ENSRNOT00000026530
Ensembl Acc Id: ENSRNOP00000093694   ⟸   ENSRNOT00000108765
Protein Domains
Gla

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04640-F1-model_v2 AlphaFold P04640 1-99 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691436
Promoter ID:EPDNEW_R1961
Type:single initiation site
Name:Bglap_1
Description:bone gamma-carboxyglutamate protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02187,742,732 - 187,742,792EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2206 AgrOrtholog
BioCyc Gene G2FUF-52485 BioCyc
Ensembl Genes ENSRNOG00000019607 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026530 ENTREZGENE
  ENSRNOT00000026530.4 UniProtKB/Swiss-Prot
InterPro GLA-like_dom_SF UniProtKB/Swiss-Prot
  GLA_domain UniProtKB/Swiss-Prot
  Osteocalcin UniProtKB/Swiss-Prot
  Osteocalcin/MGP UniProtKB/Swiss-Prot
KEGG Report rno:25295 UniProtKB/Swiss-Prot
NCBI Gene 25295 ENTREZGENE
PANTHER OSTEOCALCIN UniProtKB/Swiss-Prot
  PTHR14235 UniProtKB/Swiss-Prot
PharmGKB BGLAP RGD
PhenoGen Bglap PhenoGen
PRINTS GLABONE UniProtKB/Swiss-Prot
PROSITE GLA_1 UniProtKB/Swiss-Prot
  GLA_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019607 RatGTEx
SMART GLA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57630 UniProtKB/Swiss-Prot
UniProt A0A8I6AK32 ENTREZGENE, UniProtKB/TrEMBL
  A6J671 ENTREZGENE, UniProtKB/TrEMBL
  OSTCN_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-01 Bglap  bone gamma-carboxyglutamate protein  Bglap  bone gamma-carboxyglutamate (gla) protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Bglap  bone gamma-carboxyglutamate (gla) protein  Bglap  bone gamma-carboxyglutamate (gla) protein (osteocalcin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-14 Bglap  bone gamma-carboxyglutamate (gla) protein (osteocalcin)  Bglap2  bone gamma-carboxyglutamate protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Bglap2  bone gamma-carboxyglutamate protein 2  Bglap  bone gamma-carboxyglutamate protein  Symbol and Name updated 1299863 APPROVED
2003-04-09 Bglap  bone gamma-carboxyglutamate protein    Bone gamma-carboxyglutamate protein  Name updated 629478 APPROVED
2002-06-10 Bglap  Bone gamma-carboxyglutamate protein      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in osteoblasts 70543
gene_protein mature protein consists of 50 amino acid residues and a 49 amino acid leader peptide 1298705
gene_protein protein is 5.8 kD 1298706
gene_regulation mRNA increased by vitamin D3 and activation of Vdr (vitamin D receptor) 625466
gene_regulation interaction of acetylated H3 and H4 histones with the promoter region is mediated by transcriptional activation by vitamin D 625466
gene_regulation gene expression is regulated by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] 1298706
gene_transcript gene consists of 4 exons separated by 3 introns; spans almost 1 kb of DNA 1298706