RGD Reference Report - Alterations in serum levels of 1 alpha,25(OH)2 D3 and osteocalcin in patients with early diabetic nephropathy. - Rat Genome Database

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Alterations in serum levels of 1 alpha,25(OH)2 D3 and osteocalcin in patients with early diabetic nephropathy.

Authors: Inukai, T  Fujiwara, Y  Tayama, K  Aso, Y  Takemura, Y 
Citation: Inukai T, etal., Diabetes Res Clin Pract. 1997 Oct;38(1):53-9.
RGD ID: 7207424
Pubmed: PMID:9347246   (View Abstract at PubMed)

Serum levels of markers for bone remodeling and diabetic metabolic markers were measured in subjects with non-insulin-dependent diabetes mellitus (NIDDM) to investigate the relationship between early diabetic nephropathy and calcium/bone metabolism. 1 alpha,25(OH)2 D3 (Vit D), osteocalcin (OC), intact parathyroid hormone (PTH) and urine albumin excretion (UAE) were measured in all subjects. Serum levels of Vit D and OC were significantly decreased in diabetic subjects compared to age-matched, non-diabetic controls. In diabetic patients, a significant positive correlation was observed between intact PTH and OC. No significant correlation was found between levels of Vit D and OC. In early diabetic nephropathy without increased serum creatinine, Vit D decreased and OC increased with increasing UAE. Levels of hemoglobin Alc (HbAlc) and fructosamine (FRA) were not correlated with levels of Vit D or OC. Levels of Vit D were decreased and levels of OC were increased in diabetic subjects with proliferative retinopathy or with micro- or macro-albuminuria. CONCLUSIONS: Results of the present study indicate that changes in bone remodeling markers such as Vit D and OC levels are present in the early stages of diabetic nephropathy, and that circulating intact PTH is important in restoring the reduced OC levels in diabetic patients, probably as a reflection of bone remodeling.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Diabetic Nephropathies  IEP 7207424associated with Diabetes Mellitus more ...RGD 
Diabetic Nephropathies  ISOBGLAP (Homo sapiens)7207424; 7207424associated with Diabetes Mellitus more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bglap  (bone gamma-carboxyglutamate protein)

Genes (Mus musculus)
Bglap  (bone gamma carboxyglutamate protein)

Genes (Homo sapiens)
BGLAP  (bone gamma-carboxyglutamate protein)


Additional Information