RGD Reference Report - A 2-year follow-up study on bone mineral density and markers of bone turnover in patients with long-standing insulin-dependent diabetes mellitus. - Rat Genome Database

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A 2-year follow-up study on bone mineral density and markers of bone turnover in patients with long-standing insulin-dependent diabetes mellitus.

Authors: Miazgowski, T  Czekalski, S 
Citation: Miazgowski T and Czekalski S, Osteoporos Int. 1998;8(5):399-403.
RGD ID: 7207419
Pubmed: PMID:9850345   (View Abstract at PubMed)
DOI: DOI:10.1007/s001980050082   (Journal Full-text)

The aim of study was to evaluate, during 2-year follow-up, bone mineral density in sites with different cortical/cancellous bone ratios (lumbar spine, total body, distal site of radius) and selected markers of bone turnover (total alkaline phoshatase, osteocalcin, pyridinoline and deoxypirydinoline) in patients with long-standing insulin-dependent diabetes mellitus in comparison with healthy controls. Additionally, the influence of age, sex, smoking, duration of diabetes, the degree of metabolic control, or coexisting chronic complications of diabetes (retinopathy, incipient nephropathy, polyneuropathy) on the studied indices of bone metabolism in patients with insulin-dependent diabetes mellitus were evaluated. It was found that patients with long-standing diabetes mellitus had significantly lower bone mineral density than healthy controls (p < 0.003 in lumbar spine and p < 0.001 in total body). The incidence rate of osteopenia and osteoporosis was significantly higher in this group of patients in comparison with the controls (p < 0.005 for lumbar spine and total body and p < 0.001 for radius). In comparison with healthy subjects, diabetic patients and significantly higher, but within normal reference range, serum alkaline phosphate (p < 0.005) and osteocalcin (p < 0.05), accompanied by similar pyridinoline and not significantly increased deoxypyridinoline. Duration and metabolic control of diabetes, or the coexistence of its chronic complications, did not correlate with bone mineral density or the studied indices of bone turnover. In conclusion, diabetic osteopenia seems to be a normal bone turnover state, not influenced by the duration or degree of metabolic control of diabetes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 1 diabetes mellitus  IEP 7207419protein:increased expression:serum:RGD 
type 1 diabetes mellitus  ISOBGLAP (Homo sapiens)7207419; 7207419protein:increased expression:serum:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bglap  (bone gamma-carboxyglutamate protein)

Genes (Mus musculus)
Bglap  (bone gamma carboxyglutamate protein)

Genes (Homo sapiens)
BGLAP  (bone gamma-carboxyglutamate protein)


Additional Information