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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2206
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bglap
Name: bone gamma-carboxyglutamate protein
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bglapincreases expressionISOBglap (Mus musculus)6480464CTDGenistein results in increased expression of BGLAP mRNAPMID:24872432
Bglapmultiple interactionsISOBglap (Mus musculus)6480464CTD[Genistein co-treated with Ethanol] results in increased expression of BGLAP mRNA; [Genistein co-treated with Zinc Sulfate] results in increased expression of BGLAP mRNA; [Genistein co-treated with Zinc] results in increased expression of BGLAP mRNA; Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc Sulfate] results in increased expression of BGLAP mRNA]; Cycloheximide inhibits the reaction [[Genistein co-treated with Zinc] results in increased expression of BGLAP mRNA]PMID:17203194 PMID:24872432
Bglapmultiple interactionsISOBGLAP (Homo sapiens)6480464CTD[Genistein co-treated with ESR1 protein] results in increased expression of BGLAP mRNA; [Genistein co-treated with ESR2 protein] results in increased expression of BGLAP mRNAPMID:19347870
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