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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2206
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bglap
Name: bone gamma-carboxyglutamate protein
Acc ID: CHEBI:31638
Term: fulvestrant
Definition: A 3-hydroxy steroid that is 17beta-estradiol in which the 7alpha hydrogen has been replaced by a nonyl group in which one of the hydrogens of the terminal methyl has been replaced by a (4,4,5,5,5-pentafluoropentyl)sulfinyl group. An estrogen receptor antagonist, it is used in the treatment of breast cancer.
Chemical ID: MESH:C070081
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bglapmultiple interactionsEXP 6480464CTDfulvestrant inhibits the reaction [naringin results in increased secretion of BGLAP protein]PMID:23596885
Bglapmultiple interactionsISOBGLAP (Homo sapiens)6480464CTDfulvestrant inhibits the reaction [Estradiol results in increased expression of BGLAP mRNA]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of BGLAP mRNA]; fulvestrant inhibits the reaction [resveratrol results in increased expression of BGLAP mRNA]PMID:17689939 PMID:26362186
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