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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2206 Species: Rattus norvegicus RGD Object: Gene Symbol: Bglap Name: bone gamma-carboxyglutamate (gla) protein

Acc ID: CHEBI:16469 Term: 17beta-estradiol Definition: The 17beta-isomer of estradiol. CasRN: 50-28-2 Chemical ID: MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:619567	6480464	CTD	[Estradiol co-treated with ESR1 protein] results in increased expression of BGLAP mRNA [Estradiol co-treated with ESR2 protein] results in increased expression of BGLAP mRNA	PMID:19347870
increases expression	ISO	RGD:619567	6480464	CTD	Estradiol results in increased expression of BGLAP mRNA	PMID:17689939
decreases expression	EXP		6480464	CTD	Estradiol results in decreased expression of BGLAP protein	PMID:15979666 PMID:15917159
multiple interactions	ISO	RGD:619567	6480464	CTD	fulvestrant inhibits the reaction [Estradiol results in increased expression of BGLAP mRNA]	PMID:17689939
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of BGLAP mRNA	PMID:16964405
decreases expression	EXP		6480464	CTD	Estradiol results in decreased expression of BGLAP protein	PMID:15917159 PMID:15979666