RGD Reference Report - Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis. - Rat Genome Database

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Relationship between serum undercarboxylated osteocalcin and hyaluronan levels in patients with bilateral knee osteoarthritis.

Authors: Naito, K  Watari, T  Obayashi, O  Katsube, S  Nagaoka, I  Kaneko, K 
Citation: Naito K, etal., Int J Mol Med. 2012 May;29(5):756-60. doi: 10.3892/ijmm.2012.897. Epub 2012 Jan 26.
RGD ID: 6483563
Pubmed: PMID:22294259   (View Abstract at PubMed)
DOI: DOI:10.3892/ijmm.2012.897   (Journal Full-text)

Serum undercarboxylated osteocalcin (s-ucOC) is a marker for vitamin K metabolism (deficiency). The aim of this study was to investigate the serum levels of ucOC in patients with bilateral knee osteoarthritis (K-OA), and the correlation between ucOC and other biomarkers for K-OA. A total of 25 patients (22 women, 3 men, mean age 76.0+/-7.8, range 54-88 years, mean BMI 24.9+/-4.7) with a Kellgren-Lawrence grade of 3 or 4 for bilateral knee were enrolled in this study. The levels of s-ucOC and other biomarkers were measured. The levels of s-ucOC (5.66+/-4.70 ng/ml) as well as other cartilage metabolism markers, were elevated in the patients; however, bone metabolism markers were within the normal ranges. Of interest, there was a significant correlation between s-ucOC and serum hyaluronan (a marker for synovitis) (P<0.05). Our findings suggest that vitamin K metabolism may be associated with synovitis in patients with K-OA, and s-ucOC could be a biomarker for K-OA.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Knee Osteoarthritis  IEP 6483563 RGD 
Knee Osteoarthritis  ISOBGLAP (Homo sapiens)6483563; 6483563 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bglap  (bone gamma-carboxyglutamate protein)

Genes (Mus musculus)
Bglap  (bone gamma carboxyglutamate protein)

Genes (Homo sapiens)
BGLAP  (bone gamma-carboxyglutamate protein)


Additional Information