Bglap (bone gamma-carboxyglutamate protein) - Rat Genome Database

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Gene: Bglap (bone gamma-carboxyglutamate protein) Chinchilla lanigera
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Symbol: Bglap
Name: bone gamma-carboxyglutamate protein
RGD ID: 8869097
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); calcium-dependent protein binding (ortholog); hormone activity (ortholog); INVOLVED IN bone development (ortholog); brain development (ortholog); cellular response to BMP stimulus (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; ASSOCIATED WITH asthma (ortholog); autosomal dominant hypocalcemia (ortholog); Bone Fractures (ortholog); FOUND IN cell projection (ortholog); collagen-containing extracellular matrix (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: osteocalcin
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,381,156 - 2,381,978 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,381,091 - 2,382,114 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Bglap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,381,156 - 2,381,978 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,381,091 - 2,382,114 (+)NCBIChiLan1.0ChiLan1.0
BGLAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,242,184 - 156,243,317 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1156,242,184 - 156,243,317 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,211,975 - 156,213,108 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,478,629 - 154,479,736 (+)NCBINCBI36Build 36hg18NCBI36
Build 341153,025,077 - 153,026,185NCBI
Celera1129,284,933 - 129,286,094 (+)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1127,573,050 - 127,574,222 (+)NCBIHuRef
CHM1_11157,607,924 - 157,609,096 (+)NCBICHM1_1
T2T-CHM13v2.01155,380,641 - 155,381,774 (+)NCBIT2T-CHM13v2.0
Bglap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39388,290,802 - 88,291,773 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl388,290,808 - 88,291,771 (-)EnsemblGRCm39 Ensembl
GRCm38388,383,495 - 88,384,466 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl388,383,501 - 88,384,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv37388,187,417 - 88,188,386 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,469,422 - 88,470,391 (-)NCBIMGSCv36mm8
Celera388,423,135 - 88,424,104 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.82NCBI
Bglap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,136,341 - 176,137,318 (-)NCBIGRCr8
mRatBN7.22173,838,518 - 173,839,495 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,838,518 - 173,839,495 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2180,982,788 - 180,983,765 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,005,149 - 179,006,126 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02173,605,147 - 173,606,124 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02187,741,770 - 187,748,445 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,741,770 - 187,742,747 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,144,494 - 207,150,926 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,482,313 - 180,483,290 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12180,432,418 - 180,433,396 (-)NCBI
Celera2167,783,260 - 167,784,237 (-)NCBICelera
Cytogenetic Map2q34NCBI
BGLAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2193,602,088 - 93,605,108 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1193,333,985 - 93,337,006 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01131,583,789 - 131,586,459 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11135,413,871 - 135,416,432 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,413,871 - 135,416,432 (+)Ensemblpanpan1.1panPan2
BGLAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,630,092 - 41,630,976 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,630,098 - 41,665,791 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,117,871 - 41,118,763 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,494,521 - 41,495,418 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,494,525 - 41,516,608 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,275,834 - 41,276,717 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,329,023 - 41,329,894 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,613,117 - 41,614,007 (-)NCBIUU_Cfam_GSD_1.0
Bglap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,449,368 - 26,451,906 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,481,355 - 5,482,155 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365805,480,023 - 5,482,288 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BGLAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,623,716 - 7,626,353 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,623,883 - 7,624,812 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660386,916,245 - 6,918,859 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bglap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,527,538 - 1,528,109 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,526,625 - 1,528,235 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000005321   ⟹   ENSCLAP00000005225
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555452,381,156 - 2,381,978 (+)Ensembl
RefSeq Acc Id: XM_005411659   ⟹   XP_005411716
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555452,381,091 - 2,382,114 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005411716 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000005225
  ENSCLAP00000005225.1
RefSeq Acc Id: XP_005411716   ⟸   XM_005411659
- UniProtKB: A0A8C2UV25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000005225   ⟸   ENSCLAT00000005321
Protein Domains
Gla


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000003710 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000005321 ENTREZGENE
  ENSCLAT00000005321.1 UniProtKB/TrEMBL
InterPro GLA-like_dom_SF UniProtKB/TrEMBL
  GLA_domain UniProtKB/TrEMBL
  Osteocalcin UniProtKB/TrEMBL
  Osteocalcin/MGP UniProtKB/TrEMBL
NCBI Gene Bglap ENTREZGENE
PANTHER OSTEOCALCIN UniProtKB/TrEMBL
  PTHR14235 UniProtKB/TrEMBL
PRINTS GLABONE UniProtKB/TrEMBL
PROSITE GLA_1 UniProtKB/TrEMBL
  GLA_2 UniProtKB/TrEMBL
SMART GLA UniProtKB/TrEMBL
Superfamily-SCOP SSF57630 UniProtKB/TrEMBL
UniProt A0A8C2UV25 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Bglap  bone gamma-carboxyglutamate protein    bone gamma-carboxyglutamate (gla) protein  Symbol and/or name change 5135510 APPROVED