RGD Reference Report - Comparative study of quantitative ultrasonography and dual-energy X-ray absorptiometry for evaluating renal osteodystrophy in children with chronic kidney disease.

General

Comparative study of quantitative ultrasonography and dual-energy X-ray absorptiometry for evaluating renal osteodystrophy in children with chronic kidney disease.
Authors:	Christoforidis, A Printza, N Gkogka, C Siomou, E Challa, A Kazantzidou, E Kollios, K Papachristou, F
Citation:	Christoforidis A, etal., J Bone Miner Metab. 2011 May;29(3):321-7. doi: 10.1007/s00774-010-0220-1. Epub 2010 Sep 16.
RGD ID:	7207235
Pubmed:	PMID:20845051 (View Abstract at PubMed)
DOI:	DOI:10.1007/s00774-010-0220-1 (Journal Full-text)
Our aim was to assess bone parameters in children with chronic kidney disease (CKD) with both dual-energy X-ray absorptiometry (DXA) and quantitative ultrasonography (QUS) and additionally with biochemical markers of bone turnover. Twenty children (12 boys and 8 girls) with CKD and a mean decimal age of 9.47 +/- 4.44 years were included in the study where anthropometric parameters (height and weight), pubertal status, bone mineral density (BMD) at lumbar spine, speed of sound (SOS) measured by QUS at radius and at tibia, and biochemical markers of bone metabolism were measured. Six patients (30%) had tibial SOS Z score <-1, and 52.7% had radial SOS Z score <-1, whereas only 16.67% had BMD Z score <-1. Patients had significantly increased levels of serum intact parathormone (p < 0.001), serum bone alkaline phosphatase (BAP) (p < 0.001) and serum N-terminal-mid fragment (aminoacids 1-43) of osteocalcin (p < 0.001) compared to controls, whereas serum osteoprotegerin was significantly decreased in patients compared to controls (p = 0.001). SOS was significantly correlated to BAP (r = -0.586, p = 0.013 and r = -0.709, p = 0.001, respectively, for radius and tibia). In conclusion no association between DXA and QUS measurements was documented in our study, whereas QUS was better correlated to biochemical indices of ROD.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
end stage renal disease		IEP		7207235	protein:increased expression:serum	RGD
end stage renal disease		ISO	BGLAP (Homo sapiens)	7207235; 7207235	protein:increased expression:serum	RGD

Objects Annotated

Genes (Rattus norvegicus)

Bglap (bone gamma-carboxyglutamate protein)

Genes (Mus musculus)

Bglap (bone gamma carboxyglutamate protein)

Genes (Homo sapiens)

BGLAP (bone gamma-carboxyglutamate protein)

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Comparative study of quantitative ultrasonography and dual-energy X-ray absorptiometry for evaluating renal osteodystrophy in children with chronic kidney disease.