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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:hypertrophic cardiomyopathy pathway
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Accession:PW:0000296 term browser browse the term
Definition:Hypertrophic cardiomyopathy, or HCM, is a disease of the myocardium (the muscle of the heart) in which a portion of the myocardium is thickened. Many physiological and pathological conditions as well as many pathways underlie the hypertrophic response.
Synonyms:exact_synonym: HCM pathway
 related_synonym: KEGG:05410


show annotations for term's descendants           Sort by:
hypertrophic cardiomyopathy pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme IEA KEGG rno:05410 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Actb actin, beta IEA KEGG rno:05410 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 IEA KEGG rno:05410 NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523 		JBrowse link
G Actg1 actin, gamma 1 IEA KEGG rno:05410 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
Ensembl chr 3:105,619,737...105,624,232 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 IEA KEGG rno:05410 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C IEA KEGG rno:05410 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D IEA KEGG rno:05410 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215 		JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F IEA KEGG rno:05410 NCBI chr  X:14,868,096...14,896,413
Ensembl chr  X:14,868,024...14,896,413 		JBrowse link
G Cacna1s calcium voltage-gated channel subunit alpha1 S IEA KEGG rno:05410 NCBI chr13:47,493,949...47,564,194
Ensembl chr13:47,493,949...47,564,318 		JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 IEA KEGG rno:05410 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969 		JBrowse link
G Cacna2d2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 IEA KEGG rno:05410 NCBI chr 8:108,072,208...108,203,516
Ensembl chr 8:108,072,454...108,203,173 		JBrowse link
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 IEA KEGG rno:05410 NCBI chr16:4,098,439...4,912,498
Ensembl chr16:4,098,445...4,912,351 		JBrowse link
G Cacna2d4 calcium voltage-gated channel auxiliary subunit alpha2delta 4 IEA KEGG rno:05410 NCBI chr 4:152,408,588...152,521,478
Ensembl chr 4:152,408,657...152,521,268 		JBrowse link
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 IEA KEGG rno:05410 NCBI chr10:82,998,182...83,018,838
Ensembl chr10:82,998,182...83,018,694 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 IEA KEGG rno:05410 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106 		JBrowse link
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 IEA KEGG rno:05410 NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074 		JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 IEA KEGG rno:05410 NCBI chr 3:36,906,771...37,169,165
Ensembl chr 3:36,910,427...37,168,944 		JBrowse link
G Cacng1 calcium voltage-gated channel auxiliary subunit gamma 1 IEA KEGG rno:05410 NCBI chr10:92,652,924...92,665,612
Ensembl chr10:92,652,614...92,665,783 		JBrowse link
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 IEA KEGG rno:05410 NCBI chr 7:109,572,838...109,698,516
Ensembl chr 7:109,574,459...109,697,227 		JBrowse link
G Cacng3 calcium voltage-gated channel auxiliary subunit gamma 3 IEA KEGG rno:05410 NCBI chr 1:177,201,361...177,297,019
Ensembl chr 1:177,201,288...177,297,024 		JBrowse link
G Cacng4 calcium voltage-gated channel auxiliary subunit gamma 4 IEA KEGG rno:05410 NCBI chr10:92,683,778...92,745,842
Ensembl chr10:92,683,761...92,746,126 		JBrowse link
G Cacng5 calcium voltage-gated channel auxiliary subunit gamma 5 IEA KEGG rno:05410 NCBI chr10:92,827,441...92,869,632
Ensembl chr10:92,829,196...92,869,614 		JBrowse link
G Cacng6 calcium voltage-gated channel auxiliary subunit gamma 6 IEA KEGG rno:05410 NCBI chr 1:65,732,910...65,747,377
Ensembl chr 1:65,732,632...65,747,341 		JBrowse link
G Cacng7 calcium voltage-gated channel auxiliary subunit gamma 7 IEA KEGG rno:05410 NCBI chr 1:65,800,059...65,831,246
Ensembl chr 1:65,800,355...65,831,006 		JBrowse link
G Cacng8 calcium voltage-gated channel auxiliary subunit gamma 8 IEA KEGG rno:05410 NCBI chr 1:65,755,334...65,775,567
Ensembl chr 1:65,755,334...65,779,089 		JBrowse link
G Dag1 dystroglycan 1 IEA KEGG rno:05410 NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325 		JBrowse link
G Des desmin IEA KEGG rno:05410 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Emd emerin IEA KEGG rno:05410 NCBI chr  X:152,038,990...152,042,190
Ensembl chr  X:152,038,998...152,045,807 		JBrowse link
G Igf1 insulin-like growth factor 1 IEA KEGG rno:05410 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il6 interleukin 6 IEA KEGG rno:05410 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itga1 integrin subunit alpha 1 IEA KEGG rno:05410 NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Itga10 integrin subunit alpha 10 IEA KEGG rno:05410 NCBI chr 2:184,182,869...184,202,172
Ensembl chr 2:184,182,869...184,202,172 		JBrowse link
G Itga11 integrin subunit alpha 11 IEA KEGG rno:05410 NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407 		JBrowse link
G Itga2 integrin subunit alpha 2 IEA KEGG rno:05410 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itga2b integrin subunit alpha 2b IEA KEGG rno:05410 NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168 		JBrowse link
G Itga4 integrin subunit alpha 4 IEA KEGG rno:05410 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Itga5 integrin subunit alpha 5 IEA KEGG rno:05410 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837 		JBrowse link
G Itga6 integrin subunit alpha 6 IEA KEGG rno:05410 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428 		JBrowse link
G Itga7 integrin subunit alpha 7 IEA KEGG rno:05410 NCBI chr 7:1,360,125...1,388,886
Ensembl chr 7:1,359,940...1,388,450 		JBrowse link
G Itga9 integrin subunit alpha 9 IEA KEGG rno:05410 NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754 		JBrowse link
G Itgb1 integrin subunit beta 1 ISS
IEA		 KEGG
RGD		 PMID:9633916 rno:05410, RGD:1302874 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Itgb3 integrin subunit beta 3 IEA KEGG rno:05410 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Itgb4 integrin subunit beta 4 IEA KEGG rno:05410 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012 		JBrowse link
G Itgb5 integrin subunit beta 5 IEA KEGG rno:05410 NCBI chr11:66,828,428...66,944,231
Ensembl chr11:66,829,285...66,944,472 		JBrowse link
G Itgb6 integrin subunit beta 6 IEA KEGG rno:05410 NCBI chr 3:45,046,295...45,170,532
Ensembl chr 3:45,048,044...45,121,671 		JBrowse link
G Itgb7 integrin subunit beta 7 IEA KEGG rno:05410 NCBI chr 7:133,347,927...133,364,955
Ensembl chr 7:133,347,960...133,364,876 		JBrowse link
G Itgb8 integrin subunit beta 8 IEA KEGG rno:05410 NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476 		JBrowse link
G Lama2 laminin subunit alpha 2 IEA KEGG rno:05410 NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530 		JBrowse link
G Lmna lamin A/C IEA KEGG rno:05410 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Mybpc3 myosin binding protein C3 IEA KEGG rno:05410 NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405 		JBrowse link
G Myh6 myosin heavy chain 6 IEA KEGG rno:05410 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 IEA KEGG rno:05410 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Myl2 myosin light chain 2 IEA KEGG rno:05410 NCBI chr12:34,454,223...34,468,554
Ensembl chr12:34,454,218...34,468,983 		JBrowse link
G Myl3 myosin light chain 3 IEA KEGG rno:05410 NCBI chr 8:110,738,669...110,744,814
Ensembl chr 8:110,738,661...110,744,816 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 IEA KEGG rno:05410 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 IEA KEGG rno:05410 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 IEA KEGG rno:05410 NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661 		JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 IEA KEGG rno:05410 NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872 		JBrowse link
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 IEA KEGG rno:05410 NCBI chr 7:129,963,105...129,980,532
Ensembl chr 7:129,963,105...129,980,561 		JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 IEA KEGG rno:05410 NCBI chr 4:10,010,890...10,252,155
Ensembl chr 4:10,010,890...10,252,142 		JBrowse link
G Prkag3 protein kinase AMP-activated non-catalytic subunit gamma 3 IEA KEGG rno:05410 NCBI chr 9:76,295,715...76,304,959
Ensembl chr 9:76,295,715...76,304,959 		JBrowse link
G Ryr2 ryanodine receptor 2 IEA KEGG rno:05410 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Sgca sarcoglycan, alpha IEA KEGG rno:05410 NCBI chr10:79,904,698...79,922,808
Ensembl chr10:79,908,738...79,922,813 		JBrowse link
G Sgcb sarcoglycan, beta IEA KEGG rno:05410 NCBI chr14:34,563,614...34,578,614
Ensembl chr14:34,563,608...34,578,583 		JBrowse link
G Sgcd sarcoglycan, delta IEA KEGG rno:05410 NCBI chr10:31,346,480...32,328,364
Ensembl chr10:31,280,511...31,724,840 		JBrowse link
G Sgcg sarcoglycan, gamma IEA KEGG rno:05410 NCBI chr15:35,388,836...35,435,072
Ensembl chr15:35,386,534...35,435,148 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 IEA KEGG rno:05410 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEA KEGG rno:05410 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 IEA KEGG rno:05410 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 IEA KEGG rno:05410 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Tnf tumor necrosis factor IEA KEGG rno:05410 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type IEA KEGG rno:05410 NCBI chr16:6,400,801...6,405,634
Ensembl chr16:6,402,171...6,405,634 		JBrowse link
G Tnni3 troponin I3, cardiac type IEA KEGG rno:05410 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Tnnt2 troponin T2, cardiac type IEA KEGG rno:05410 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
G Tpm1 tropomyosin 1 IEA KEGG rno:05410 NCBI chr 8:67,635,479...67,662,330
Ensembl chr 8:67,635,479...67,662,802 		JBrowse link
G Tpm2 tropomyosin 2 IEA KEGG rno:05410 NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992 		JBrowse link
G Tpm3 tropomyosin 3 IEA KEGG rno:05410 NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013 		JBrowse link
G Tpm4 tropomyosin 4 IEA KEGG rno:05410 NCBI chr16:17,684,415...17,698,456
Ensembl chr16:17,683,195...17,705,984 		JBrowse link
G Ttn titin IEA KEGG rno:05410 NCBI chr 3:61,652,432...61,924,912
Ensembl chr 3:61,652,439...61,924,741 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    disease pathway 1954
      cardiovascular system disease pathway 254
        cardiomyopathy pathway 195
          hypertrophic cardiomyopathy pathway 79
paths to the root