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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-pilocarpine | increases expression | EXP | | 6480464 | Pilocarpine results in increased expression of ITGA5 protein | CTD | PMID:12851778 | 1-naphthyl isothiocyanate | multiple interactions | ISO | RGD:1351478 | 6480464 | 1-Naphthylisothiocyanate results in increased expression of [ITGB6 protein co-treated with ITGA5 protein]; more ... | CTD | PMID:21037076 | 1-naphthyl isothiocyanate | multiple interactions | ISO | RGD:10817 | 6480464 | [ITGA5 protein co-treated with ITGB6 protein] promotes the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of SMAD2 protein] | CTD | PMID:21037076 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1351478 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ITGA5 mRNA | CTD | PMID:16051281 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1351478 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ITGA5 mRNA | CTD | PMID:16051281 PMID:22902829 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of ITGA5 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:10817 | 6480464 | [Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of ITGA5 mRNA | CTD | PMID:16214954 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of ITGA5 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of ITGA5 mRNA | CTD | PMID:21346803 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:1351478 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of ITGA5 mRNA | CTD | PMID:12419474 | 4-vinylcyclohexene dioxide | affects expression | ISO | RGD:10817 | 6480464 | 4-vinyl-1-cyclohexene dioxide affects the expression of ITGA5 mRNA | CTD | PMID:20829426 | 5-bromo-2'-deoxyuridine | increases expression | ISO | RGD:1351478 | 6480464 | Bromodeoxyuridine results in increased expression of ITGA5 protein; more ... | CTD | PMID:7519154 | acetone | increases expression | ISO | RGD:1351478 | 6480464 | Acetone results in increased expression of ITGA5 mRNA | CTD | PMID:12720008 | acetylsalicylic acid | decreases expression | ISO | RGD:1351478 | 6480464 | Aspirin results in decreased expression of ITGA5 mRNA | CTD | PMID:15928584 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1351478 | 6480464 | Tretinoin promotes the reaction [rosiglitazone results in increased expression of ITGA5 protein] | CTD | PMID:19467017 | aluminium oxide | multiple interactions | ISO | RGD:1351478 | 6480464 | [Aluminum Oxide co-treated with Magnesium] results in increased expression of ITGA5 protein | CTD | PMID:12209937 | benzo[a]pyrene | increases expression | ISO | RGD:10817 | 6480464 | Benzo(a)pyrene results in increased expression of ITGA5 mRNA | CTD | PMID:22228805 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:10817 | 6480464 | Mustard Gas results in increased expression of ITGA5 mRNA | CTD | PMID:15674843 | cadmium atom | decreases expression | ISO | RGD:1351478 | 6480464 | Cadmium results in decreased expression of ITGA5 mRNA | CTD | PMID:20570719 | cadmium atom | increases expression | ISO | RGD:1351478 | 6480464 | Cadmium results in increased expression of ITGA5 mRNA | CTD | PMID:20570719 | capsaicin | increases expression | EXP | | 6480464 | Capsaicin results in increased expression of ITGA5 mRNA | CTD | PMID:16278290 | cobalt dichloride | increases expression | ISO | RGD:1351478 | 6480464 | cobaltous chloride results in increased expression of ITGA5 protein | CTD | PMID:16798617 | copper atom | multiple interactions | ISO | RGD:1351478 | 6480464 | ITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] | CTD | PMID:18346929 | copper(0) | multiple interactions | ISO | RGD:1351478 | 6480464 | ITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] | CTD | PMID:18346929 | cortisol | increases expression | ISO | RGD:1351478 | 6480464 | Hydrocortisone results in increased expression of ITGA5 mRNA | CTD | PMID:21267416 | DDT | increases expression | ISO | RGD:1351478 | 6480464 | DDT results in increased expression of ITGA5 mRNA | CTD | PMID:22902829 | diazepam | increases expression | ISO | RGD:1351478 | 6480464 | Diazepam results in increased expression of ITGA5 mRNA | CTD | PMID:19114084 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of ITGA5 mRNA | CTD | PMID:15829613 PMID:21266533 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of ITGA5 mRNA | CTD | PMID:21266533 PMID:15829613 | disodium selenite | increases expression | ISO | RGD:1351478 | 6480464 | Sodium Selenite results in increased expression of ITGA5 mRNA | CTD | PMID:18175754 | endosulfan | increases expression | ISO | RGD:1351478 | 6480464 | Endosulfan results in increased expression of ITGA5 mRNA | CTD | PMID:22902829 | ethanol | increases expression | ISO | RGD:1351478 | 6480464 | Ethanol results in increased expression of ITGA5 mRNA | CTD | PMID:12720008 | folic acid | affects expression | ISO | RGD:1351478 | 6480464 | Folic Acid affects the expression of ITGA5 mRNA | CTD | PMID:16361273 | furosemide | decreases expression | EXP | | 6480464 | Furosemide results in decreased expression of ITGA5 mRNA | CTD | PMID:16526316 | heptachlor | increases expression | ISO | RGD:1351478 | 6480464 | Heptachlor results in increased expression of ITGA5 mRNA | CTD | PMID:22902829 | hydrogen peroxide | decreases expression | ISO | RGD:1351478 | 6480464 | Hydrogen Peroxide results in decreased expression of ITGA5 mRNA | CTD | PMID:12419474 | leuprolide | multiple interactions | ISO | RGD:1351478 | 6480464 | Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]] | CTD | PMID:17143537 | LY294002 | multiple interactions | ISO | RGD:1351478 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]] | CTD | PMID:16465378 | magnesium atom | multiple interactions | ISO | RGD:1351478 | 6480464 | [Aluminum Oxide co-treated with Magnesium] results in increased expression of ITGA5 protein | CTD | PMID:12209937 | methotrexate | increases expression | ISO | RGD:1351478 | 6480464 | Methotrexate results in increased expression of ITGA5 mRNA | CTD | PMID:17400583 | nimesulide | multiple interactions | ISO | RGD:1351478 | 6480464 | MAPK1 mutant form inhibits the reaction [nimesulide results in decreased expression of ITGA5 protein]; more ... | CTD | PMID:15825163 | nimesulide | decreases expression | ISO | RGD:1351478 | 6480464 | nimesulide results in decreased expression of ITGA5 mRNA; more ... | CTD | PMID:15825163 | quinoline | multiple interactions | ISO | RGD:1351478 | 6480464 | quinoline analog binds to and results in decreased activity of [ITGA5 protein binds to ITGB3 protein] | CTD | PMID:16984141 | resveratrol | multiple interactions | ISO | RGD:1351478 | 6480464 | arginyl-glycyl-aspartic acid inhibits the reaction [resveratrol binds to [ITGA5 protein binds to ITGB3 protein]]; more ... | CTD | PMID:16790523 | resveratrol | decreases expression | ISO | RGD:1351478 | 6480464 | resveratrol results in decreased expression of ITGA5 protein | CTD | PMID:18089832 | resveratrol | affects binding | ISO | RGD:1351478 | 6480464 | resveratrol binds to [ITGA5 protein binds to ITGB3 protein] | CTD | PMID:16790523 | rosiglitazone | increases expression | ISO | RGD:1351478 | 6480464 | rosiglitazone results in increased expression of ITGA5 protein | CTD | PMID:19467017 | rosiglitazone | multiple interactions | ISO | RGD:1351478 | 6480464 | Tretinoin promotes the reaction [rosiglitazone results in increased expression of ITGA5 protein] | CTD | PMID:19467017 | silicon dioxide | increases expression | ISO | RGD:10817 | 6480464 | Silicon Dioxide results in increased expression of ITGA5 mRNA | CTD | PMID:19073995 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:1351478 | 6480464 | tert-Butylhydroperoxide results in decreased expression of ITGA5 mRNA | CTD | PMID:12419474 | tert-butyl hydroperoxide | increases expression | EXP | | 6480464 | tert-Butylhydroperoxide results in increased expression of ITGA5 mRNA | CTD | PMID:22659508 | topotecan | affects response to substance | ISO | RGD:1351478 | 6480464 | ITGA5 protein affects the susceptibility to Topotecan | CTD | PMID:16217747 | trans-resveratrol | multiple interactions | ISO | RGD:1351478 | 6480464 | arginyl-glycyl-aspartic acid inhibits the reaction [resveratrol binds to [ITGA5 protein binds to ITGB3 protein]]; more ... | CTD | PMID:16790523 | trans-resveratrol | decreases expression | ISO | RGD:1351478 | 6480464 | resveratrol results in decreased expression of ITGA5 protein | CTD | PMID:18089832 | trans-resveratrol | affects binding | ISO | RGD:1351478 | 6480464 | resveratrol binds to [ITGA5 protein binds to ITGB3 protein] | CTD | PMID:16790523 | troglitazone | increases expression | ISO | RGD:1351478 | 6480464 | troglitazone results in increased expression of ITGA5 mRNA | CTD | PMID:19140230 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| Bacterial invasion of epithelial cells | |
| Dilated cardiomyopathy | |
| ECM-receptor interaction | |
| Focal adhesion | |
| Hematopoietic cell lineage | |
| Hypertrophic cardiomyopathy (HCM) | |
| Pertussis | |
| Phagosome | |
| PI3K-Akt signaling pathway | |
| Regulation of actin cytoskeleton | |
| Pathway Interaction Database | Angiopoietin receptor Tie2-mediated signaling (PID:200079) |
| Arf6 trafficking events (PID:200057) | |
| Beta1 integrin cell surface interactions (PID:200016) | |
| CXCR4-mediated signaling events (PID:200099) | |
| Integrin family cell surface interactions (PID:200039) | |
| Signaling events mediated by focal adhesion kinase (PID:200224) | |
| Syndecan-2-mediated signaling events (PID:200192) | |
| Syndecan-4-mediated signaling events (PID:200134) | |
| Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling (PID:200139) | |
| VEGFR3 signaling in lymphatic endothelium (PID:200218) | |
References - curated| 1. |
Dina OA, etal., Eur J Neurosci. 2004 Feb;19(3):634-42. |
| 2. |
Dina OA, etal., Pain. 2005 May;115(1-2):191-203. |
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Kim Y, etal., Mol Immunol. 2011 Apr;48(8):1035-45. Epub 2011 Feb 23. |
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MGD data from the GO Consortium |
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Milliano MT and Luxon BA, J Hepatol 2003 Jul;39(1):32-7. |
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Nawata J, etal., Cardiovasc Res 1999 Aug 1;43(2):371-81. |
| 7. |
Pi L, etal., Hepatology. 2008 Mar;47(3):996-1004. |
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Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
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RGD automated import pipeline for gene-chemical interactions |
| 11. |
Takada Y, etal., Genome Biol. 2007;8(5):215. |
References - uncurated| PubMed | 11869556 |
| 12493556 | |
| 14644171 | |
| 15635129 | |
| 15722407 | |
| 16100245 | |
| 16554304 | |
| 17123509 | |
| 17213186 | |
| 17483236 | |
| 17715430 | |
| 18330891 | |
| 18638458 | |
| 19027743 | |
| 20049771 | |
| 21178109 | |
| 21559527 | |
| 21747167 | |
| 22865233 | |
| 23325413 |
RGD Disease Portals| Itga5 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Itga5 (Rattus norvegicus) |
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| ITGA5 (Homo sapiens) |
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| Itga5 (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001108118 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06052802 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01052841 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474035 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001108118 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001101588 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001101588 | (Get FASTA) |
| GenBank Protein | EDL86784 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000036832 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000052152 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000055277 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 315346 | ENTREZGENE |
| HomoloGene Group ID | 20508 | ENTREZGENE |
| InterPro | FG-GAP | UniProtKB/TrEMBL |
| Int_alpha_beta-p | UniProtKB/TrEMBL | |
| Integrin_alpha | UniProtKB/TrEMBL | |
| Integrin_alpha-2 | UniProtKB/TrEMBL | |
| Integrin_alpha_C_CS | UniProtKB/TrEMBL | |
| IPI | IPI00870485 | UniProtKB/TrEMBL |
| IPI00957850 | UniProtKB/TrEMBL | |
| KEGG Report | rno:315346 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | FG-GAP | UniProtKB/TrEMBL |
| Integrin_alpha2 | UniProtKB/TrEMBL | |
| PRINTS | INTEGRINA | UniProtKB/TrEMBL |
| PROSITE | FG_GAP | UniProtKB/TrEMBL |
| INTEGRIN_ALPHA | UniProtKB/TrEMBL | |
| SMART | Int_alpha | UniProtKB/TrEMBL |
| UniGene | Rn.100796 | ENTREZGENE |
| UniProt | D4ACU9_RAT | UniProtKB/TrEMBL |
| Q7M074_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2010-02-24 | Itga5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | Itga5 | integrin, alpha 5 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2010-02-09 | Itga5 | integrin, alpha 5 | Itga5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2010-01-14 | Itga5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | Itga5 | integrin, alpha 5 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2009-12-15 | Itga5 | integrin, alpha 5 | Itga5 | integrin alpha 5 (fibronectin receptor alpha) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-05-19 | Itga5 | integrin alpha 5 (fibronectin receptor alpha) | Itga5 | integrin alpha 5 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2007-04-11 | Itga5 | integrin alpha 5 | Itga5_mapped | integrin alpha 5 (mapped) | Symbol updated | 9333 | APPROVED |
| 2007-04-11 | Itga5_mapped | integrin alpha 5 (mapped) | Itga5_retired | integrin alpha 5 (mapped) | Data Merged | 9333 | APPROVED |
| 2007-04-11 | Itga5_retired | Itga5 | integrin alpha 5 (mapped) | Symbol updated | 9333 | PENDING | |
| 2006-11-19 | Itga5 | integrin alpha 5 (mapped) | Symbol and Name status set to provisional | 1724 | PROVISIONAL | ||
| 2005-11-17 | Itga5_mapped | integrin alpha 5 (mapped) | Symbol and Name updated | 14094 | APPROVED | ||
| 2002-06-10 | Itga5 | Integrin, alpha 5 (fibronectin receptor, alpha) | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_function | acts as a receptor for fibronectin with beta 1 integrin subunit | 1300196 |
| gene_physical_interaction | interacts with integrin beta 1 subunit | 1300196 |
| gene_process | involved in activation of hepatic stellate cells | 1300196 |
| More on Itga5 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2925 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-30 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.