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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Retina Reperfusion Injury
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Accession:DOID:9001725 term browser browse the term
Definition:Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the retina, including swelling; hemorrhage; necrosis; and damage from free radicals.
Synonyms:exact_synonym: RIRI;   Retinal Ischemia-Reperfusion Injury
 xref: PMID:32452260


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Retina Reperfusion Injury term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 treatment IDA RGD PMID:22143029 RGD:5686888 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Bad BCL2-associated agonist of cell death treatment IDA RGD PMID:23056591 RGD:10053711 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator treatment IEP RGD PMID:23056591 RGD:10053711 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator treatment IDA RGD PMID:25535961 RGD:11522737 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 treatment IEP RGD PMID:23056591 RGD:10053711 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor ISO RGD PMID:10549664 RGD:8655861 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Casp7 caspase 7 IEP RGD PMID:20702827 RGD:5684535 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cat catalase treatment IEP protein:decreased expression,decreased activity:retina: RGD PMID:22509733 RGD:9068919 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment IDA RGD PMID:24325836 RGD:11526144 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Clu clusterin IEP RGD PMID:15139011 RGD:1581194 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cntf ciliary neurotrophic factor treatment IDA RGD PMID:8125754 RGD:8655591 NCBI chr 1:209,887,854...209,889,877
Ensembl chr 1:209,887,854...209,889,877 		JBrowse link
G Dusp1 dual specificity phosphatase 1 treatment IMP RGD PMID:21094639 RGD:7495849 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Fgf2 fibroblast growth factor 2 treatment IEP
ISO		 RGD PMID:9561364 PMID:14975212 PMID:8125754 RGD:8554857, RGD:8655585, RGD:8655591 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fxn frataxin ameliorates ISO RGD PMID:27537261 PMID:27537261 RGD:401793704, RGD:401793704 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G Glul glutamate-ammonia ligase treatment IEP RGD PMID:22008240 RGD:401794422 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Hdac2 histone deacetylase 2 treatment ISO RGD PMID:23696608 RGD:9590210 NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Hgf hepatocyte growth factor treatment ISO
IEP		 mRNA,protein:increased expression:retina: RGD PMID:11818401 PMID:11818401 RGD:8548551, RGD:8548551 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hmgb1 high mobility group box 1 IDA RGD PMID:21999229 RGD:10402064 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 IEP associated with Glaucoma RGD PMID:20357190 RGD:4145289 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 IDA RGD PMID:21310899 RGD:10402767 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment IMP
IEP		 associated with Hypertension RGD PMID:10235552 PMID:15007035 RGD:8547704, RGD:8547707 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1a interleukin 1 alpha IEP RGD PMID:7890488 RGD:7401191 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta IEP RGD PMID:7890488 RGD:7401191 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 IEP mRNA:increased expression:retina: RGD PMID:16530172 RGD:7829807 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 IEP
ISO		 mRNA:decreased expression:retina
protein:decreased expression:retina, blood vessel		 RGD PMID:16330144 PMID:20132867 RGD:8662868, RGD:8662890 NCBI chr13:84,802,026...84,835,383
Ensembl chr13:84,802,009...84,835,461 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 IEP protein:increased expression:retina RGD PMID:17026968 RGD:2317696 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IEP RGD PMID:19668425 RGD:7495824 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Nos3 nitric oxide synthase 3 treatment IEP
IDA		 mRNA:altered expression:retina (rat)
protein:increased expression:retinal vasculature, retinal ganglion cell layer (rat)		 RGD PMID:9950605 PMID:12634478 PMID:11496119 RGD:7771570, RGD:7775037, RGD:7775036 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase IEP protein:increased expression:retina, cytosol (rat) RGD PMID:19122832 RGD:13208943 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Ren renin treatment IMP RGD PMID:24709336 RGD:11039406 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Rnf2 ring finger protein 2 IEP RGD PMID:20740046 RGD:9491844 NCBI chr13:63,553,964...63,584,047
Ensembl chr13:63,554,862...63,583,099 		JBrowse link
G Serpinf1 serpin family F member 1 ISO human protein in a mouse model RGD PMID:16822505 RGD:8554871 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Sod2 superoxide dismutase 2 treatment IEP
ISO		 protein:decreased activity:retina: RGD PMID:22240151 PMID:22240151 RGD:8158043, RGD:8158043 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 treatment IDA RGD PMID:21858029 RGD:8694310 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tlr4 toll-like receptor 4 ISO RGD PMID:21031135 RGD:7794771 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor IEP
IDA
IMP		 protein:increased expression:retina: RGD PMID:18660426 PMID:18660426 PMID:18660426 RGD:7387281, RGD:7387281, RGD:7387281 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A IDA RGD PMID:17591953 RGD:7421609 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xdh xanthine dehydrogenase treatment IMP RGD PMID:9288448 RGD:13210506 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    sensory system disease 6961
      eye disease 3492
        retinal disease 1223
          Retina Reperfusion Injury 38
Path 2
Term Annotations click to browse term
  disease 18969
    disease of anatomical entity 18249
      nervous system disease 14091
        Neurologic Manifestations 10055
          sensory system disease 6961
            eye disease 3492
              retinal disease 1223
                Retina Reperfusion Injury 38
paths to the root