Gene: Kcnj10 (potassium inwardly-rectifying channel, subfamily J, member 10)
Rattus norvegicus |
| Symbol: |
Kcnj10
|
| Name: |
potassium inwardly-rectifying channel, subfamily J, member 10
|
| Description: |
ENCODES a protein that exhibits identical protein binding; receptor binding; inward rectifier potassium channel activity (ortholog); INVOLVED IN inflammatory response; L-glutamate import; membrane hyperpolarization; ASSOCIATED WITH Optic Nerve Injuries; Retinal Vein Occlusion; DEAFNESS, AUTOSOMAL RECESSIVE 4, WITH ENLARGED VESTIBULAR AQUEDUCT (ortholog); FOUND IN apical plasma membrane; basolateral plasma membrane; dystrophin-associated glycoprotein complex; INTERACTS WITH ammonium chloride; barium(0); cadmium dichloride |
| Type: |
protein-coding
|
| RefSeq Status: |
PROVISIONAL
|
| Also known as: |
ATP-sensitive inward rectifier potassium channel 10; ATP-sensitive inward rectifier potassium channel KAB-2; BIR10; BIRK1; brain-specific inwardly rectifying K(+) channel 1; inward rectifier K(+) channel Kir4.1; kir4.1; potassium channel, inwardly rectifying subfamily J member 10; potassium inwardly-rectifying channel, subfamily J, member 10
|
| Orthologs: |
Homo sapiens : KCNJ10
(potassium inwardly-rectifying channel, subfamily J, member 10)
HGNC
Mus musculus : Kcnj10
(potassium inwardly-rectifying channel, subfamily J, member 10)
MGI
|
| Latest Assembly: |
RGSC Genome Assembly v3.4
|
| Position: |
| Map | Chr | Position | Strand | Source |
|---|
Rat Cytogenetic Map | 13 | q24 | | NCBI | RGSC Genome Assembly v5.0 | 13 | 95,245,046 - 95,274,535 | + | NCBI | RGSC Genome Assembly v3.4 | 13 | 88,341,102 - 88,370,591 | + | NCBI | Rat Celera Assembly | 13 | 84,412,238 - 84,441,711 | + | NCBI | Genome Assembly 3.1 | 13 | 88,529,985 - 88,559,475 | + | NCBI |
|
| Model |
|
 Disease Annotations |
 Gene-Chemical Interaction Annotations
| 17beta-estradiol | increases expression | ISO | RGD:731912 | 6480464 | Estradiol results in increased expression of KCNJ10 mRNA | CTD | PMID:21632981 | | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:731912 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KCNJ10 mRNA | CTD | PMID:20106945 | | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:731912 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KCNJ10 mRNA | CTD | PMID:20106945 PMID:21632981 | | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:62113 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of KCNJ10 mRNA | CTD | PMID:21889950 | | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of KCNJ10 mRNA | CTD | PMID:16483693 | | barium(0) | decreases activity | EXP | | 6480464 | Barium results in decreased activity of KCNJ10 protein | CTD | PMID:16331678 PMID:17978865 | | barium(0) | decreases activity | EXP | | 6480464 | Barium results in decreased activity of KCNJ10 protein | CTD | PMID:17978865 PMID:16331678 | | benzo[a]pyrene | decreases expression | ISO | RGD:731912 | 6480464 | Benzo(a)pyrene results in decreased expression of KCNJ10 mRNA | CTD | PMID:20106945 | | benzo[a]pyrene | decreases expression | ISO | RGD:731912 | 6480464 | Benzo(a)pyrene results in decreased expression of KCNJ10 mRNA | CTD | PMID:20106945 PMID:21632981 | | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of KCNJ10 promoter | CTD | PMID:22457795 | | cocaine | increases expression | EXP | | 6480464 | Cocaine results in increased expression of KCNJ10 mRNA | CTD | PMID:16076954 | | disodium selenite | increases expression | ISO | RGD:731912 | 6480464 | Sodium Selenite results in increased expression of KCNJ10 mRNA | CTD | PMID:18175754 | | nickel sulfate | decreases expression | ISO | RGD:731912 | 6480464 | nickel sulfate results in decreased expression of KCNJ10 mRNA | CTD | PMID:16780908 | | potassium atom | affects transport | ISO | RGD:62113 | 6480464 | KCNJ10 protein affects the transport of Potassium | CTD | PMID:18023363 | | potassium atom | multiple interactions | EXP | | 6480464 | [ALB protein results in decreased expression of KCNJ10 protein] which results in decreased import of Potassium | CTD | PMID:17121744 | | quercetin | decreases expression | ISO | RGD:731912 | 6480464 | Quercetin results in decreased expression of KCNJ10 mRNA | CTD | PMID:21632981 | | trimellitic anhydride | increases expression | ISO | RGD:62113 | 6480464 | trimellitic anhydride results in increased expression of KCNJ10 mRNA | CTD | PMID:19042947 | |
| 70181 | BpQTLcluster11 | Blood pressure QTL cluster 11 | 3.4 | | Blood pressure | | 13 | 52688796 | 97688796 | Rat |
| 738027 | Lnnr6 | Liver neoplastic nodule remodeling QTL 6 | 3.3 | | Liver neoplastic nodule remodeling frequency | | 13 | 78189125 | 111154910 | Rat |
| 738026 | Lnnr5 | Liver neoplastic nodule remodeling QTL 5 | 3.29 | | Liver neoplastic nodule remodeling frequency | | 13 | 62072299 | 94306205 | Rat |
| 1298066 | Bp159 | Blood pressure QTL 159 | | .004 | Blood pressure | salt-loaded systolic | 13 | 47690518 | 92690518 | Rat |
| 1331783 | Bp221 | Blood pressure QTL 221 | 3.72886 | | Blood pressure | time series calculation | 13 | 72141292 | 90551272 | Rat |
| 1300166 | Kidm6 | Kidney mass QTL 6 | 3.93 | | Kidney mass | salt-loaded | 13 | 72141292 | 90551272 | Rat |
| 1354655 | Bp241 | Blood pressure QTL 241 | 3.9 | | Blood pressure | systolic | 13 | 37458331 | 105788017 | Rat |
| 1576318 | Schws5 | Schwannoma susceptibility QTL 5 | | .0351 | Neural tumor susceptibility | tumor incidence, length of survival time | 13 | 65464406 | 110464406 | Rat |
| 1581570 | Eae17 | Experimental allergic encephalomyelitis QTL 17 | 4.1 | | Brain/spinal cord inflammation | demyelination | 13 | 28645448 | 106366082 | Rat |
| 1641901 | Alcrsp6 | Alcohol response QTL 6 | | | Alcohol response | loss of righting reflex | 13 | 55689252 | 100689252 | Rat |
| 2293341 | Glom15 | Glomerulus QTL 15 | 7.4 | | Renal pathology | glomerulus inflammation | 13 | 78189125 | 106076220 | Rat |
| 2293687 | Bss26 | Bone structure and strength QTL 26 | 4.6 | .0001 | Bone structure | | 13 | 68910877 | 111154910 | Rat |
| 2293702 | Bss34 | Bone structure and strength QTL 34 | 4.61 | .0001 | Bone structure | | 13 | 68910877 | 111154910 | Rat |
| 4889606 | Gluco63 | Glucose level QTL 63 | 2.86 | .003 | Glucose level | | 13 | 84280242 | 111154910 | Rat |
| 1354621 | Rf47 | Renal function QTL 47 | 3.7 | | Kidney renin concentration | | 13 | 32030139 | 105788017 | Rat |
| 1302791 | Stl29 | Serum triglyceride level QTL 29 | 3.3 | .0011 | Lipid level | triglyceride level | 13 | 88260176 | 90551272 | Rat |
| 7207885 | Glom27 | Glomerulus QTL 27 | 3.9 | | Renal pathology | glomerulus inflammation | 13 | 10556042 | 106075835 | Rat |