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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Wolff-Parkinson-White syndrome
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Accession:DOID:384 term browser browse the term
Definition:A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulses are abnormally conducted to the HEART VENTRICLES via an ACCESSORY CONDUCTING PATHWAY that is located between the wall of the right or left atria and the ventricles, also known as a BUNDLE OF KENT. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.
Synonyms:exact_synonym: Anomalous A-V excitation;   Anomalous Ventricular Excitation Syndrome;   Auriculoventricular Accessory Pathway Syndrome;   False Bundle-Branch Block Syndrome;   Ventricular Pre-Excitation with Arrhythmia;   WPW syndrome;   anomalous atrioventricular excitation
 narrow_synonym: FAMILIAL HYPERTROPHIC CARDIOMYOPATHY WITH WOLFF-PARKINSON-WHITE SYNDROME;   Wolff-Parkinson-White syndrome, childhood-onset;   accessory atrioventricular pathways
 related_synonym: WOLFF-PARKINSON-WHITE PATTERN;   Wolf Parkinson White syndrome
 primary_id: MESH:D014927
 alt_id: OMIM:194200
 xref: EFO:1001450;   GARD:7897;   ICD9CM:426.7;   NCI:C35132
For additional species annotation, visit the Alliance of Genome Resources.


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Wolff-Parkinson-White syndrome term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc9 ATP binding cassette subfamily C member 9 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356 		JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523 		JBrowse link
G Actn2 actinin alpha 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr17:58,143,334...58,210,622
Ensembl chr17:58,142,625...58,210,622 		JBrowse link
G Akap9 A-kinase anchoring protein 9 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:22584458 PMID:28492532 PMID:32233023 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606 		JBrowse link
G Ank2 ankyrin 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 PMID:28191889 PMID:28492532 PMID:32233023 NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A ISS OMIM:194200 MouseDO NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25633834 PMID:25741868 PMID:28492532 PMID:28600387 PMID:28616568 More... NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:28492532 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450 		JBrowse link
G Casq2 calsequestrin 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:18684293 PMID:21618644 PMID:28492532 PMID:32693635 NCBI chr 2:189,526,003...189,582,276
Ensembl chr 2:189,525,960...189,582,267 		JBrowse link
G Dnaaf3 dynein, axonemal, assembly factor 3 ISO ClinVar Annotator: match by term: Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White Syndrome ClinVar PMID:22876777 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr 1:69,291,300...69,299,365
Ensembl chr 1:69,291,454...69,299,344 		JBrowse link
G Dpp6 dipeptidyl peptidase like 6 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 4:7,589,386...8,508,666
Ensembl chr 4:7,591,009...8,508,532 		JBrowse link
G Dsp desmoplakin ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 PMID:28492532 PMID:32233023 NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800 		JBrowse link
G Flna filamin A ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:28492532 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Flnc filamin C ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 PMID:28492532 NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844 		JBrowse link
G Fnip1 folliculin interacting protein 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr10:38,567,728...38,650,824
Ensembl chr10:38,567,729...38,650,824 		JBrowse link
G Gja5 gap junction protein, alpha 5 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952 		JBrowse link
G Gpd1l glycerol-3-phosphate dehydrogenase 1 like ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 PMID:28492532 NCBI chr 8:114,591,103...114,620,771
Ensembl chr 8:114,588,487...114,620,723 		JBrowse link
G Jup junction plakoglobin ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 PMID:27532257 PMID:28492532 PMID:31983221 PMID:32233023 NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:10753933 PMID:20301308 PMID:21777565 PMID:25741868 PMID:28280240 More... NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr10:96,060,834...96,071,397
Ensembl chr10:96,060,821...96,071,445 		JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:9799083 PMID:12388934 PMID:15840476 PMID:17470695 PMID:19490272 More... NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669 		JBrowse link
G Lama4 laminin subunit alpha 4 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:23861362 PMID:28492532 PMID:30847666 NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347 		JBrowse link
G Lamc1 laminin subunit gamma 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492 		JBrowse link
G Lmna lamin A/C ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 PMID:28492532 PMID:28663758 PMID:31383942 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 ISS OMIM:194200 MouseDO NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597 		JBrowse link
G Mybpc3 myosin binding protein C3 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:16858239 PMID:18533079 PMID:19150014 PMID:20031602 PMID:20173211 More... NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405 		JBrowse link
G Myh11 myosin heavy chain 11 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 NCBI chr10:743,364...838,459
Ensembl chr10:743,685...838,459 		JBrowse link
G Myh6 myosin heavy chain 6 ISO DNA:missense mutation:exon:p.E1885K (c.5653G>A) (human)
ClinVar Annotator: match by term: Wolff-Parkinson-White pattern		 ClinVar
RGD		 PMID:15998695 PMID:20215591 PMID:22194935 PMID:22361390 PMID:23299917 More... RGD:12792281 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720 		JBrowse link
G Myh7 myosin heavy chain 7 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:7581410 PMID:10521296 PMID:11186938 PMID:11447480 PMID:12749056 More... NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217 		JBrowse link
G Nde1 nudE neurodevelopment protein 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 NCBI chr10:839,788...883,946
Ensembl chr10:839,788...883,869 		JBrowse link
G Nebl nebulette ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr17:80,113,891...80,466,331
Ensembl chr17:80,118,543...80,466,210 		JBrowse link
G Nodal nodal growth differentiation factor ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:19064609 PMID:25741868 PMID:28492532 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837 		JBrowse link
G Pitx2 paired-like homeodomain 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 2:217,717,738...217,737,293
Ensembl chr 2:217,717,693...217,737,293 		JBrowse link
G Prdm16 PR/SET domain 16 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 PMID:28492532 PMID:32233023 NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601 		JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern | ClinVar Annotator: match by term: Wolff-Parkinson-White syndrome, childhood-onset
ClinVar Annotator: match by term: Anomalous ventricular excitation syndrome | ClinVar Annotator: match by term: False bundle branch block syndrome | ClinVar Annotator: match by term: Wolff-Parkinson-White pattern | ClinVar Annotator: match by term: Wolff-Parkinson-White syndrome, childhood-onset
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD
RGD		 PMID:10355918 PMID:10820940 PMID:11407343 PMID:11407351 PMID:11586962 More... RGD:1580719, RGD:1580718 NCBI chr 4:10,010,890...10,252,155
Ensembl chr 4:10,010,890...10,252,142 		JBrowse link
G Rbm20 RNA binding motif protein 20 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 1:252,683,760...252,907,465
Ensembl chr 1:252,683,771...252,886,060 		JBrowse link
G Rhbdf1 rhomboid 5 homolog 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr10:15,406,832...15,419,765
Ensembl chr10:15,406,859...15,419,763 		JBrowse link
G Ryr2 ryanodine receptor 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:24033266 PMID:24558114 PMID:25041964 PMID:25467552 PMID:25637381 More... NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:18752142 PMID:18752973 PMID:22581653 PMID:25326637 PMID:25741868 More... NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Slc26a4 solute carrier family 26 member 4 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:11317356 PMID:12642503 PMID:14679580 PMID:15099345 PMID:15355436 More... NCBI chr 6:48,107,575...48,153,762
Ensembl chr 6:48,107,588...48,145,703 		JBrowse link
G Snta1 syntrophin, alpha 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:23631430 PMID:28492532 NCBI chr 3:142,876,285...142,906,737
Ensembl chr 3:142,876,296...142,906,709 		JBrowse link
G Tbx20 T-box transcription factor 20 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 8:23,200,104...23,258,218
Ensembl chr 8:23,204,507...23,258,175 		JBrowse link
G Tbx5 T-box transcription factor 5 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 NCBI chr12:36,686,344...36,739,253
Ensembl chr12:36,688,014...36,734,885 		JBrowse link
G Tcap titin-cap ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 PMID:28492532 PMID:28771489 PMID:32233023 NCBI chr10:83,381,719...83,382,887
Ensembl chr10:83,381,719...83,382,887 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:18781618 PMID:27879313 PMID:28492532 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Tnni3 troponin I3, cardiac type ISO ClinVar Annotator: match by term: Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White Syndrome | ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:9241277 PMID:11815426 PMID:12860912 PMID:15524171 PMID:15607392 More... NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Tnnt1 troponin T1, slow skeletal type ISO ClinVar Annotator: match by term: Familial Hypertrophic Cardiomyopathy with Wolff-Parkinson-White Syndrome ClinVar PMID:18414213 PMID:24033266 PMID:25741868 PMID:28492532 NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721 		JBrowse link
G Tnnt2 troponin T2, cardiac type ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:9714088 PMID:14636924 PMID:16115869 PMID:16858239 PMID:18533079 More... NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388 		JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 PMID:28492532 PMID:32233023 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532 		JBrowse link
G Ttc39a tetratricopeptide repeat domain 39A ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 5:124,165,102...124,204,740
Ensembl chr 5:124,151,760...124,204,973 		JBrowse link
G Ttn titin ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:23975875 PMID:25589632 PMID:25741868 PMID:28492532 PMID:31983221 More... NCBI chr 3:61,652,432...61,924,912
Ensembl chr 3:61,652,439...61,924,741 		JBrowse link
G Vcl vinculin ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar PMID:25741868 PMID:28492532 PMID:32233023 NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606 		JBrowse link
G Wwp1 WW domain containing E3 ubiquitin protein ligase 1 ISO ClinVar Annotator: match by term: Wolff-Parkinson-White pattern ClinVar NCBI chr 5:33,092,379...33,185,887
Ensembl chr 5:33,098,494...33,186,046 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    physical disorder 4965
      congenital heart disease 1349
        Wolff-Parkinson-White syndrome 53
Path 2
Term Annotations click to browse term
  disease 18969
    Developmental Disease 14401
      Congenital, Hereditary, and Neonatal Diseases and Abnormalities 13418
        Congenital Abnormalities 7583
          Cardiovascular Abnormalities 1548
            congenital heart disease 1349
              Wolff-Parkinson-White syndrome 53
paths to the root