Gene: Casq2 (calsequestrin 2 (cardiac muscle))
Rattus norvegicus
Symbol:
Casq2
Name:
calsequestrin 2 (cardiac muscle)
Description:
ENCODES a protein that exhibits protein homodimerization activity; protein kinase C binding; calcium ion binding (ortholog); INVOLVED IN negative regulation of ryanodine-sensitive calcium-release channel activity; regulation of cardiac muscle cell contraction; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; PARTICIPATES IN calcium/calcium-mediated signaling pathway; ASSOCIATED WITH Aortic Stenosis, Supravalvular; Diabetic Cardiomyopathies; Heart Failure; FOUND IN sarcoplasmic reticulum; Z disc; cytoplasm (ortholog); INTERACTS WITH ammonium chloride; bis(2-ethylhexyl) phthalate; chlorpyrifos
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
calsequestrin 2; calsequestrin, cardiac muscle isoform; calsequestrin-2; cardCSQ; SR calcium binding protein
Orthologs:
Homo sapiens : CASQ2
(calsequestrin 2 (cardiac muscle))
HGNC
Casq2
(calsequestrin 2)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 2 q34 NCBI RGSC Genome Assembly v5.0 2 223,945,611 - 224,001,893 + NCBI RGSC Genome Assembly v3.4 2 197,182,938 - 197,239,201 + NCBI Rat Celera Assembly 2 181,958,395 - 182,014,660 + NCBI Genome Assembly 3.1 2 197,145,718 - 197,201,199 + NCBI
Model
Gene-Chemical Interaction Annotations
17beta-estradiol multiple interactions ISO RGD:737298 6480464 [Estradiol binds to ESR2 protein] which results in increased expression of CASQ2 mRNA CTD PMID:20404318 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:737298 6480464 Tetrachlorodibenzodioxin results in increased expression of CASQ2 mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:737298 6480464 Tetrachlorodibenzodioxin results in increased expression of CASQ2 mRNA CTD PMID:20106945 PMID:21632981 4,4'-diaminodiphenylmethane decreases expression ISO RGD:737299 6480464 4,4'-diaminodiphenylmethane results in decreased expression of CASQ2 mRNA CTD PMID:18648102 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of CASQ2 mRNA CTD PMID:16483693 benzo[a]pyrene decreases expression ISO RGD:737299 6480464 Benzo(a)pyrene results in decreased expression of CASQ2 mRNA CTD PMID:22228805 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of CASQ2 mRNA CTD PMID:20920545 bisphenol A affects expression ISO RGD:737299 6480464 bisphenol A affects the expression of CASQ2 protein CTD PMID:23418087 bisphenol A affects methylation ISO RGD:737299 6480464 bisphenol A affects the methylation of CASQ2 promoter CTD PMID:23418087 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of CASQ2 mRNA CTD PMID:18668222 dibutyl phthalate increases expression ISO RGD:737299 6480464 Dibutyl Phthalate results in increased expression of CASQ2 mRNA CTD PMID:21266533 dibutyl phthalate increases expression ISO RGD:737299 6480464 Dibutyl Phthalate results in increased expression of CASQ2 mRNA CTD PMID:17361019 PMID:21266533
1578671 Bmd10 Bone mineral density QTL 10 5.4 Bone mineral density femoral neck cortical vBMD 2 9670332 227150249 Rat 1358913 Cm41 Cardiac mass QTL 41 2.73 Cardiac mass 2 24474447 212169089 Rat 1358917 Cm42 Cardiac mass QTL 42 2.82 Cardiac mass 2 24474447 212169089 Rat 61467 Bp14 Blood pressure QTL 14 2.2 Blood pressure 2 42866342 210636008 Rat 631266 Bp132 Blood pressure QTL 132 .0005 Blood pressure systolic 2 46542246 210636169 Rat 1331760 Bp206 Blood pressure QTL 206 3.62454 Blood pressure time series calculation 2 56214854 210636169 Rat 1298080 Bp163 Blood pressure QTL 163 .02 Blood pressure systolic 2 66680022 210636169 Rat 1354648 Bp239 Blood pressure QTL 239 .001 Blood pressure systolic 2 66680209 235799396 Rat 1354605 Rf48 Renal function QTL 48 2.9 Creatinine level serum 2 75806326 214989298 Rat 61374 Edpm2 Estrogen-dependent pituitary mass QTL 2 4.42 .86 Gland mass pituitary 2 77630629 210636169 Rat 724534 Uae6 Urinary albumin excretion QTL 6 10 Renal function urine albumin level 2 79796833 227150249 Rat 1581569 Uae32 Urinary albumin excretion QTL 32 .0001 Renal function urine albumin level 2 79796977 227150051 Rat 1581576 Pur7 Proteinuria QTL 7 .0001 Renal function urine protein level 2 79796977 227150051 Rat 1354622 Kidm16 Kidney mass QTL 16 3 Kidney mass left kidney mass 2 82826122 231465091 Rat 1354649 Kidm17 Kidney mass QTL 17 2.9 Kidney mass left kidney mass adjujsted for tibia length 2 82826122 236153712 Rat 631507 Bp105 Blood pressure QTL 105 .001 Blood pressure 2 116874922 221284686 Rat 634308 Sach6 Saccharin preference QTL 6 4.9 Consumption level saccharin preference 2 116874922 221284686 Rat 1578648 Bss11 Bone structure and strength QTL 11 4.7 Bone structure femoral neck cortical area 2 118264490 220244597 Rat 1554319 Bmd2 Bone mineral density QTL 2 13.4 .0001 Bone mineral density spine area by pQCT 2 118264840 221131552 Rat 1300165 Rf9 Renal function QTL 9 3.28 Renal function hypertension related glomerular damage 2 138700979 210636169 Rat 70175 BpQTLCluster3 Blood pressure QTL cluster 3 2.76 Blood pressure 2 140403692 210636008 Rat 1581502 Esta3 Estrogen-induced thymic atrophy QTL 3 Gland mass thymus 2 141755026 197256313 Rat 1359022 Ppulsi1 Prepulse inhibition QTL 1 3.63 Prepulse inhibition 2 141755026 222281918 Rat 1331805 Cm29 Cardiac mass QTL 29 3.50746 Cardiac mass 2 146228221 232307864 Rat 1331794 Bp202 Blood pressure QTL 202 3.66819 Blood pressure systolic 2 146228221 232307864 Rat 71113 Cari2 Carrageenan-induced inflammation QTL 2 2.7 .009 Carrageenan-induced inflammation 2 146659370 210636169 Rat 1581578 Cm49 Cardiac mass QTL 49 4.9 .01 Cardiac mass left ventricle 2 148790600 227150249 Rat 61401 Niddm2 Non-insulin dependent diabetes mellitus QTL 2 4.54 Glucose level postprandial 2 152256313 197256313 Rat 1598833 Bp295 Blood pressure QTL 295 3.5 Blood pressure systolic 2 154238265 199238265 Rat 1641925 Alcrsp2 Alcohol response QTL 2 Alcohol response loss of righting reflex 2 155101972 230157845 Rat 1641891 Alcrsp17 Alcohol response QTL 17 Alcohol response loss of righting reflex 2 155101972 247295816 Rat 1598805 Memor8 Memory QTL 8 3 Memory navigation-spatial 2 155920709 197555821 Rat 631501 Bp101 Blood pressure QTL 101 2.4 Blood pressure systolic 2 155920808 210636008 Rat 1354609 Niddm62 Non-insulin dependent diabetes mellitus QTL 62 4.72 .000006 Insulin level post-pancreatectomy 2 156142685 210636169 Rat 2301966 Bp322 Blood pressure QTL 322 3.58 Blood pressure systolic 2 156142685 210636169 Rat 724568 Uae13 Urinary albumin excretion QTL 13 4.4 Renal function urine albumin level 2 161170272 218568266 Rat 1359032 Hrtrt18 Heart rate QTL 18 Heart rate salt-induced bradycardia 2 163154227 200390471 Rat 1302793 Bw16 Body weight QTL 16 5 .0001 Body weight 2 163154358 210636008 Rat 1358900 Bw48 Body weight QTL 48 4.88 Body weight 2 163154358 227150051 Rat 1298074 Bp164 Blood pressure QTL 164 .003 Blood pressure salt-loaded systolic 2 165636169 210636169 Rat 1298076 Bp166 Blood pressure QTL 166 .0009 Blood pressure systolic 2 165636169 210636169 Rat 1298085 Bp165 Blood pressure QTL 165 .0006 Blood pressure salt-loaded systolic 2 165636169 210636169 Rat 1358356 Srcrt1 Stress Responsive Cort QTL1 3.66 Hypothalamic-pituitary-adrenal axis corticosterone post-stress 2 167857161 231465091 Rat 2306901 Bp337 Blood pressure QTL 337 .01 Blood pressure salt-loaded systolic 2 170338294 236153712 Rat 1331734 Bp204 Blood pressure QTL 204 3.61192 Blood pressure mean arterial 2 174730375 232307864 Rat 61469 Bp16 Blood pressure QTL 16 5.64 Blood pressure 2 177484675 222484675 Rat 70162 Bp63 Blood pressure QTL 63 5.64 Blood pressure 2 177484675 222484675 Rat 2293084 Iddm26 Insulin dependent diabetes mellitus QTL 26 2.9 Glucose level insulin-dependent 2 181710214 222281918 Rat 1359031 Bp275 Blood pressure QTL 275 Blood pressure systolic 2 183664122 228664122 Rat 2300189 Bmd48 Bone mineral density QTL 48 5.8 .0001 Bone mineral density 2 187512114 232512114 Rat 61417 Cia10 Collagen induced arthritis QTL 10 3.4 Joint/bone inflammation type II collagen induced 2 188136088 233136088 Rat 4889834 Pur24 Proteinuria QTL 24 5.8 .014 Renal function urine protein level 2 191378142 210636169 Rat 738013 Alc15 Alcohol consumption QTL 15 4.1 .00022 Consumption level alcohol amount 2 192489056 237489056 Rat 61458 Bp10 Blood pressure QTL 10 3.42 Blood pressure salt-loaded 2 196657749 224108082 Rat 1298083 Bp158 Blood pressure QTL 158 2.62 Blood pressure salt-loaded 2 196657749 224108082 Rat
Gene-Chemical Interaction Annotations
