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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-ropivacaine | decreases activity | ISO | RGD:1353354 | 6480464 | ropivacaine results in decreased activity of KCNQ1 protein | CTD | PMID:16931984 | (S)-ropivacaine | multiple interactions | ISO | RGD:1353354 | 6480464 | ropivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein] | CTD | PMID:16931984 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:731777 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of KCNQ1 mRNA | CTD | PMID:18648102 | 8-bromo-3',5'-cyclic AMP | increases expression | ISO | RGD:1353354 | 6480464 | 8-Bromo Cyclic Adenosine Monophosphate results in increased expression of KCNQ1 mRNA | CTD | PMID:22079614 | acrylamide | decreases activity | ISO | RGD:1353354 | 6480464 | Acrylamide analog results in decreased activity of KCNQ1 protein | CTD | PMID:16904708 | acrylamide | multiple interactions | ISO | RGD:1353354 | 6480464 | KCNE1 protein promotes the reaction [Acrylamide analog results in decreased activity of KCNQ1 protein] | CTD | PMID:16904708 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of KCNQ1 mRNA | CTD | PMID:16483693 | atenolol | affects response to substance | ISO | RGD:1353354 | 6480464 | KCNQ1 gene affects the susceptibility to Atenolol | CTD | PMID:15028050 | barium chloride | multiple interactions | ISO | RGD:1353354 | 6480464 | barium chloride results in decreased activity of [KCNQ1 protein binds to KCNE1 protein] | CTD | PMID:16909339 | barium(0) | multiple interactions | ISO | RGD:1353354 | 6480464 | Barium results in decreased activity of [KCNQ1 protein binds to KCNE1 protein] | CTD | PMID:16909339 | benzo[a]pyrene | increases expression | ISO | RGD:1353354 | 6480464 | Benzo(a)pyrene results in increased expression of KCNQ1 mRNA | CTD | PMID:22316170 | benzo[a]pyrene | decreases expression | ISO | RGD:731777 | 6480464 | Benzo(a)pyrene results in decreased expression of KCNQ1 mRNA | CTD | PMID:22228805 | bis(2-chloroethyl) sulfide | affects expression | EXP | | 6480464 | Mustard Gas affects the expression of KCNQ1 mRNA | CTD | PMID:15651846 | bis(2-ethylhexyl) phthalate | increases expression | EXP | | 6480464 | Diethylhexyl Phthalate results in increased expression of KCNQ1 mRNA | CTD | PMID:20920545 | bupivacaine | multiple interactions | ISO | RGD:1353354 | 6480464 | Bupivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]; more ... | CTD | PMID:16931984 | bupivacaine | increases response to substance | ISO | RGD:1353354 | 6480464 | KCNQ1 protein mutant form results in increased susceptibility to Bupivacaine | CTD | PMID:16931984 | bupivacaine | decreases activity | ISO | RGD:1353354 | 6480464 | Bupivacaine results in decreased activity of KCNQ1 protein | CTD | PMID:16931984 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of KCNQ1 mRNA | CTD | PMID:19167457 | clofibrate | increases expression | ISO | RGD:731777 | 6480464 | Clofibrate results in increased expression of KCNQ1 mRNA | CTD | PMID:17585979 | diazoxide | multiple interactions | ISO | RGD:1353354 | 6480464 | Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]; more ... | CTD | PMID:16909339 | isoprenaline | multiple interactions | ISO | RGD:1353354 | 6480464 | Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]; more ... | CTD | PMID:16909339 | mepivacaine | multiple interactions | ISO | RGD:1353354 | 6480464 | Mepivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein] | CTD | PMID:16931984 | mepivacaine | decreases activity | ISO | RGD:1353354 | 6480464 | Mepivacaine results in decreased activity of KCNQ1 protein | CTD | PMID:16931984 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:731777 | 6480464 | Ethylnitrosourea results in increased mutagenesis of KCNQ1 gene | CTD | PMID:16724327 | naphthalene | increases expression | ISO | RGD:731777 | 6480464 | naphthalene results in increased expression of KCNQ1 mRNA | CTD | PMID:18978301 | potassium atom | multiple interactions | ISO | RGD:1353354 | 6480464 | [KCNQ1 protein binds to KCNE1 protein] which affects the transport of Potassium | CTD | PMID:16909339 | potassium atom | multiple interactions | ISO | RGD:731777 | 6480464 | 6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dimethylchromane inhibits the reaction [[KCNQ1 protein binds to KCNE3 protein] which affects the transport of Potassium] | CTD | PMID:11527966 | propranolol | affects response to substance | ISO | RGD:1353354 | 6480464 | KCNQ1 gene affects the susceptibility to Propranolol | CTD | PMID:15028050 | trimellitic anhydride | decreases expression | ISO | RGD:731777 | 6480464 | trimellitic anhydride results in decreased expression of KCNQ1 mRNA | CTD | PMID:19042947 | vanadium atom | increases expression | EXP | | 6480464 | Vanadium results in increased expression of KCNQ1 mRNA | CTD | PMID:15159208 | vanadium(0) | increases expression | EXP | | 6480464 | Vanadium results in increased expression of KCNQ1 mRNA | CTD | PMID:15159208 | zinc atom | increases expression | EXP | | 6480464 | Zinc results in increased expression of KCNQ1 mRNA | CTD | PMID:15159208 PMID:17074742 | zinc atom | increases expression | EXP | | 6480464 | Zinc results in increased expression of KCNQ1 mRNA | CTD | PMID:17074742 PMID:15159208 | zinc sulfate | increases expression | EXP | | 6480464 | Zinc Sulfate results in increased expression of KCNQ1 mRNA | CTD | PMID:17074742 | zinc(0) | increases expression | EXP | | 6480464 | Zinc results in increased expression of KCNQ1 mRNA | CTD | PMID:15159208 PMID:17074742 | zinc(0) | increases expression | EXP | | 6480464 | Zinc results in increased expression of KCNQ1 mRNA | CTD | PMID:17074742 PMID:15159208 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Cholinergic synapse |
| Gastric acid secretion | |
| Pancreatic secretion | |
| Protein digestion and absorption | |
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Cholinergic synapse |
| Gastric acid secretion | |
| Pancreatic secretion | |
| Protein digestion and absorption | |
Phenotype Annotations
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References - curated| 1. |
Chen X, etal., Vascul Pharmacol. 2002 Jul;39(1-2):33-8. |
| 2. |
Chen YH, etal., Science. 2003 Jan 10;299(5604):251-4. |
| 3. |
Chouabe C, etal., EMBO J. 1997 Sep 1;16(17):5472-9. |
| 4. |
Gohma H, etal., Physiol Genomics. 2006 Feb 14;24(3):198-206. Epub 2005 Dec 20. |
| 5. |
Grahammer F, etal., Gastroenterology. 2001 May;120(6):1363-71. |
| 6. |
Kaufhold MA, etal., Gastroenterology. 2008 Apr;134(4):1058-69. Epub 2008 Jan 18. |
| 7. |
Kunzelmann K, etal., J Membr Biol 2001 Jan 15,;179(2):155-64. |
| 8. |
Kuwamura M, etal., Vet Pathol. 2008 Jul;45(4):586-91. |
| 9. |
Lee WK, etal., Am J Physiol Cell Physiol. 2008 Apr;294(4):C879-92. Epub 2008 Jan 23. |
| 10. |
Liao T, etal., Am J Physiol Cell Physiol. 2005 Sep;289(3):C564-75. Epub 2005 Apr 20. |
| 11. |
MGD data from the GO Consortium |
| 12. |
Nakajo K, etal., Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18862-7. doi: 10.1073/pnas.1010354107. Epub 2010 Oct 20. |
| 13. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 14. |
Ohya S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Feb;282(2):G277-87. |
| 15. |
Rasmussen HB, etal., Am J Physiol Heart Circ Physiol 2004 Apr;286(4):H1300-9. Epub 2003 Dec 11. |
| 16. |
RGD automated data pipeline |
| 17. |
RGD automated import pipeline for gene-chemical interactions |
| 18. |
RGD Automated Pipelines |
| 19. |
Tester DJ, etal., Heart Rhythm. 2005 May;2(5):507-17. |
| 20. |
Tsevi I, etal., J Cell Physiol. 2005 Feb;202(2):400-10.2: id: 27199802 Error occurred: Document retrieval error: document does notexist |
| 21. |
Ullrich S, etal., Pflugers Arch. 2005 Dec;451(3):428-36. Epub 2005 Aug 30. |
| 22. |
Wang Z, etal., Mol Genet Metab. 2002 Apr;75(4):308-16. |
| 23. |
Yamada Y, etal., Biochem Biophys Res Commun 2002 Jun 7;294(2):199-204. |
References - uncurated| PubMed | 16452155 |
| 16476578 | |
| 17556370 | |
| 17631610 | |
| 18331828 | |
| 19006182 | |
| 19372749 | |
| 20861072 | |
| 22251082 | |
| 22348007 | |
| 9314834 |
RGD Disease Portals| Kcnq1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Kcnq1 (Rattus norvegicus) |
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| KCNQ1 (Homo sapiens) |
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| Kcnq1 (Mus musculus) |
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Position Markers| D1Wox9 |
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| BF389163 |
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| AA964210 |
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| Kcnq1 |
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| RH134033 |
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| BE120633 |
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| AU047567 |
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| AU047338 |
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| AU049425 |
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| UniSTS:465396 |
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| Kcnq1 |
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| Kcnq1 |
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| Kcnq1 |
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| Kcnq1 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Related Rat Strains
Nucleotide Sequences| Nucleotide RefSeqs | NM_032073 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06009397 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06009398 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009399 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009400 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009401 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009402 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009403 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009404 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009405 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009406 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009407 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009408 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009409 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009410 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009411 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009412 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009413 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009113 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009114 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009115 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009116 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009117 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009118 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009119 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009120 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009121 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009122 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009123 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009124 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009125 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009126 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009127 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01009128 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ133685 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY043394 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473953 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U92655 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_032073 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_114462 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_114462 | (Get FASTA) |
| GenBank Protein | AAB51395 | (Get FASTA) |
| AAK94669 | (Get FASTA) | |
| CAB38863 | (Get FASTA) | |
| EDM12190 | (Get FASTA) | |
| EDM12191 | (Get FASTA) | |
| EDM12192 | (Get FASTA) | |
| Q9Z0N7 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000020532 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000027875 | UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000027875 | UniProtKB/TrEMBL |
| Entrez Gene | 84020 | ENTREZGENE |
| Germonline | ENSRNOG00000020532 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 85014 | ENTREZGENE |
| InterPro | Ion_trans | UniProtKB/Swiss-Prot |
| K_chnl | UniProtKB/Swiss-Prot | |
| K_chnl_volt-dep_KCNQ | UniProtKB/Swiss-Prot | |
| K_chnl_volt-dep_KCNQ_C | UniProtKB/Swiss-Prot | |
| K_chnl_volt-dep_KCQN1_sub1 | UniProtKB/Swiss-Prot | |
| IPI | IPI00202462 | UniProtKB/TrEMBL |
| IPI00207937 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:84020 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | PTHR11537 | UniProtKB/Swiss-Prot |
| PTHR11537:SF9 | UniProtKB/Swiss-Prot | |
| Pfam | Ion_trans | UniProtKB/Swiss-Prot |
| KCNQ_channel | UniProtKB/Swiss-Prot | |
| PharmGKB | KCNQ1 | RGD |
| PRINTS | KCHANNEL | UniProtKB/Swiss-Prot |
| KCNQ1CHANNEL | UniProtKB/Swiss-Prot | |
| KCNQCHANNEL | UniProtKB/Swiss-Prot | |
| UniGene | Rn.9779 | ENTREZGENE |
| UniProt | F1LMY9_RAT | UniProtKB/TrEMBL |
| KCNQ1_RAT | UniProtKB/Swiss-Prot | |
| Q8K3P3_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2009-12-15 | Kcnq1 | potassium voltage-gated channel, KQT-like subfamily, member 1 | Kcnq1 | potassium voltage-gated channel, subfamily Q, member 1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-01-20 | Kcnq1 | potassium voltage-gated channel, subfamily Q, member 1 | potassium voltage-gated channel, KQT-like subfamily, member 1 | Name updated | 10779 | APPROVED | |
| 2002-08-07 | Kcnq1 | potassium voltage-gated channel, KQT-like subfamily, member 1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_cellular_localization | localizes to both the peripheral sarcolemma and in the T tubules | 1304271 |
| gene_expression | expressed in the antrum of the stomach, adrenal gland, thymus, retina, and skeletal muscle | 625508 |
| gene_process | coexpressed with Kcne1 and involved in the activation of the channel | 625508 |
| gene_process | generates potassium currents in the smooth muscles of the rat stomach | 625508 |
| gene_product | 453 bp | 625508 |
| gene_transcript | truncated splice variant is expressed in fetal and neonatal rat heart and suppresses potassium currents when expressed with the full length transcript | 625471 |
| More on Kcnq1 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 621503 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-07 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




