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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:735253 | 6480464 | Tetrachlorodibenzodioxin affects the expression of SCN5A mRNA | CTD | PMID:21570461 | ajmaline | affects response to substance | ISO | RGD:731255 | 6480464 | SCN5A protein affects the susceptibility to Ajmaline | CTD | PMID:15520322 PMID:10662748 | ajmaline | affects response to substance | ISO | RGD:731255 | 6480464 | SCN5A protein affects the susceptibility to Ajmaline | CTD | PMID:10662748 PMID:15520322 | ajmaline | decreases activity | ISO | RGD:735253 | 6480464 | Ajmaline results in decreased activity of SCN5A protein | CTD | PMID:20174578 | all-trans-retinoic acid | multiple interactions | ISO | RGD:731255 | 6480464 | [Tretinoin co-treated with Phenylbutyrates co-treated with 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene] results in increased expression of SCN5A protein; more ... | CTD | PMID:23284745 | amiodarone | decreases expression | ISO | RGD:735253 | 6480464 | Amiodarone results in decreased expression of SCN5A mRNA | CTD | PMID:15520326 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SCN5A mRNA | CTD | PMID:16483693 | bisphenol A | multiple interactions | ISO | RGD:731255 | 6480464 | bisphenol A binds to and results in decreased activity of SCN5A protein | CTD | PMID:22848561 | brompheniramine | decreases activity | ISO | RGD:731255 | 6480464 | Brompheniramine results in decreased activity of SCN5A protein | CTD | PMID:17010640 | chloroform | decreases activity | ISO | RGD:731255 | 6480464 | Chloroform results in decreased activity of SCN5A protein | CTD | PMID:22024336 | choline | multiple interactions | ISO | RGD:735253 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SCN5A gene | CTD | PMID:20938992 | cisapride | increases localization | ISO | RGD:731255 | 6480464 | Cisapride results in increased localization of SCN5A protein mutant form | CTD | PMID:16301357 | diazoxide | increases expression | EXP | | 6480464 | Isoproterenol results in increased expression of SCN5A mRNA | CTD | PMID:17526999 | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of SCN5A mRNA | CTD | PMID:19915844 | fluvoxamine | decreases activity | ISO | RGD:731255 | 6480464 | Fluvoxamine results in decreased activity of SCN5A protein | CTD | PMID:19875396 | fluvoxamine | affects response to substance | ISO | RGD:731255 | 6480464 | SCN5A protein affects the susceptibility to Fluvoxamine | CTD | PMID:19875396 | folic acid | multiple interactions | ISO | RGD:735253 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SCN5A gene | CTD | PMID:20938992 | isoprenaline | increases expression | EXP | | 6480464 | Isoproterenol results in increased expression of SCN5A mRNA | CTD | PMID:17526999 | L-methionine | multiple interactions | ISO | RGD:735253 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of SCN5A gene | CTD | PMID:20938992 | lidocaine | affects response to substance | ISO | RGD:731255 | 6480464 | SCN5A protein mutant form affects the susceptibility to Lidocaine | CTD | PMID:18599870 | lithium chloride | decreases activity | ISO | RGD:731255 | 6480464 | Lithium Chloride results in decreased activity of SCN5A protein | CTD | PMID:16144991 | mexiletine | affects binding | ISO | RGD:731255 | 6480464 | Mexiletine binds to SCN5A protein | CTD | PMID:22848561 | nifedipine | decreases activity | EXP | | 6480464 | Nifedipine results in decreased activity of SCN5A protein | CTD | PMID:16331678 PMID:17978865 | nifedipine | decreases activity | EXP | | 6480464 | Nifedipine results in decreased activity of SCN5A protein | CTD | PMID:17978865 PMID:16331678 | quinidine | affects response to substance | ISO | RGD:735253 | 6480464 | SCN5A gene mutant form affects the susceptibility to Quinidine | CTD | PMID:17805561 | sodium atom | affects transport | EXP | | 6480464 | SCN5A protein affects the transport of Sodium | CTD | PMID:17065252 | strychnine | multiple interactions | ISO | RGD:731255 | 6480464 | Strychnine binds to and results in decreased activity of SCN5A protein | CTD | PMID:21616062 | tetrodotoxin | decreases activity | EXP | | 6480464 | Tetrodotoxin results in decreased activity of SCN5A protein | CTD | PMID:17978865 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
References - curated| 1. |
Baroudi G, etal., Circ Res 2002 Jan 11;90(1):E11-6. |
| 2. |
Byers MR and Westenbroek RE, Arch Oral Biol. 2011 Nov;56(11):1199-220. |
| 3. |
Dhar Malhotra J, etal., Circulation. 2001 Mar 6;103(9):1303-10. |
| 4. |
GOA data from the GO Consortium |
| 5. |
Huang X, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2007 Jan;27(1):52-5. |
| 6. |
Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 7. |
Liu CJ, etal., J Biol Chem. 2003 Jan 10;278(2):1029-36. Epub 2002 Oct 24. |
| 8. |
Makita N, etal., Circulation 2002 Sep 3;106(10):1269-74. |
| 9. |
MGD data from the GO Consortium |
| 10. |
Mohler PJ, etal., Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17533-8. Epub 2004 Dec 3. |
| 11. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 12. |
Ren CT, etal., Mol Cell Biochem. 2012 Jun;365(1-2):139-48. Epub 2012 Feb 14. |
| 13. |
RGD automated data pipeline |
| 14. |
RGD automated import pipeline for gene-chemical interactions |
| 15. |
RGD Automated Pipelines |
| 16. |
Rogart RB, etal., Proc Natl Acad Sci U S A 1989 Oct;86(20):8170-4. |
| 17. |
Rokita AG and Anderson ME, Circulation. 2012 Oct 23;126(17):2125-39. doi: 10.1161/CIRCULATIONAHA.112.124990. |
| 18. |
Sato PY, etal., Circ Res. 2009 Sep 11;105(6):523-6. Epub 2009 Aug 6. |
| 19. |
Sekiguchi K, etal., Clin Neurophysiol. 2012 Feb 13. |
| 20. |
Sha Q, etal., J Physiol. 2003 Mar 1;547(Pt 2):435-40. Epub 2003 Jan 24. |
| 21. |
Tester DJ, etal., Heart Rhythm. 2005 May;2(5):507-17. |
| 22. |
Wang L, etal., Cell Physiol Biochem. 2009;23(4-6):305-16. Epub 2009 May 6. |
| 23. |
Wu WK, etal., J Cell Physiol. 2006 May;207(2):437-44. |
| 24. |
Xi Y, etal., Eur J Heart Fail. 2009 Aug;11(8):749-57. Epub 2009 Jul 7. |
References - uncurated| PubMed | 15047701 |
| 16115203 | |
| 16966585 | |
| 17900547 | |
| 18032528 | |
| 18180363 | |
| 19376164 | |
| 19745168 | |
| 20517693 | |
| 20724705 | |
| 21164104 | |
| 21677263 | |
| 22811280 | |
| 8889548 |
RGD Disease Portals| Scn5a has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Scn5a (Rattus norvegicus) |
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| SCN5A (Homo sapiens) |
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| Scn5a (Mus musculus) |
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Position Markers| D8Wox12 |
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| BI294104 |
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| RH94513 |
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| Scn3a |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001160162 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_013125 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06057558 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06057559 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06057560 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06057561 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06057562 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06057563 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01057532 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01057533 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01057534 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01057535 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01057536 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01057537 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF353637 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AJ623272 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CV796639 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FM058340 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M27902 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_013125 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_037257 | ||||||||||||||||||||
| Peptide Label: | isoform 1 | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001160162 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001153634 | ||||||||||||||||||||
| Peptide Label: | isoform 2 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001153634 | (Get FASTA) |
| NP_037257 | (Get FASTA) | |
| GenBank Protein | AAA42114 | (Get FASTA) |
| AAK38884 | (Get FASTA) | |
| CAF25042 | (Get FASTA) | |
| P15389 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000015049 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000060180 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOP00000060586 | ENTREZGENE, UniProtKB/TrEMBL | |
| Ensembl Transcript | ENSRNOT00000064555 | ENTREZGENE, UniProtKB/TrEMBL |
| ENSRNOT00000066932 | ENTREZGENE, UniProtKB/TrEMBL | |
| Entrez Gene | 25665 | ENTREZGENE |
| Germonline | ENSRNOG00000015049 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 22738 | ENTREZGENE |
| InterPro | DUF3451 | UniProtKB/Swiss-Prot |
| Ion_trans | UniProtKB/Swiss-Prot | |
| IQ_CaM_bd_region | UniProtKB/Swiss-Prot | |
| Na_channel | UniProtKB/Swiss-Prot | |
| Na_channel5 | UniProtKB/Swiss-Prot | |
| Na_trans_assoc | UniProtKB/Swiss-Prot | |
| IPI | IPI00231550 | UniProtKB/Swiss-Prot |
| IPI00930911 | UniProtKB/Swiss-Prot | |
| IPI00948167 | UniProtKB/TrEMBL | |
| IPI00952416 | UniProtKB/TrEMBL | |
| KEGG Report | rno:25665 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | DUF3451 | UniProtKB/Swiss-Prot |
| Ion_trans | UniProtKB/Swiss-Prot | |
| Na_trans_assoc | UniProtKB/Swiss-Prot | |
| PharmGKB | SCN5A | RGD |
| PRINTS | NACHANNEL | UniProtKB/Swiss-Prot |
| NACHANNEL5 | UniProtKB/Swiss-Prot | |
| PROSITE | PS50096 | UniProtKB/Swiss-Prot |
| SMART | SM00015 | UniProtKB/Swiss-Prot |
| UniGene | Rn.32074 | ENTREZGENE |
| UniProt | F1LNF5_RAT | UniProtKB/TrEMBL |
| F1LPK3_RAT | UniProtKB/TrEMBL | |
| Q6EWG5_RAT | UniProtKB/TrEMBL | |
| SCN5A_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2010-09-16 | Scn5a | sodium channel, voltage-gated, type V, alpha subunit | Scn5a | sodium channel, voltage-gated, type V, alpha | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2009-12-15 | Scn5a | sodium channel, voltage-gated, type V, alpha | Scn5a | sodium channel, voltage-gated, type V, alpha subunit | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2009-05-18 | Scn5a | sodium channel, voltage-gated, type V, alpha subunit | Scn5a | sodium channel, voltage-gated, type 5, alpha subunit | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-02-15 | Scn5a | sodium channel, voltage-gated, type 5, alpha subunit | Scn5a | sodium channel, voltage-gated, type V, alpha polypeptide | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2002-06-10 | Scn5a | Sodium channel, voltage-gated, type V, alpha polypeptide | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_disease | mutation of the human homolog cause Brugada syndrome, a cardiac disorder that leads to ventricular fibrillation and sudden death | 735235 |
| More on Scn5a | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 3637 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




