Gene: Pitx2 (paired-like homeodomain 2) Rattus norvegicus
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Symbol: Pitx2
Name: paired-like homeodomain 2
Description: ENCODES a protein that exhibits RNA polymerase II proximal promoter sequence-specific DNA binding; transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding; chromatin binding (ortholog); INVOLVED IN brain development; female gonad development; male gonad development; PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; ASSOCIATED WITH autosomal dominant polycystic kidney disease; Hypothyroidism; hypothyroidism; FOUND IN nucleus; cytoplasm (ortholog); transcription factor complex (ortholog); INTERACTS WITH 1,3-dinitrobenzene; all-trans-retinoic acid; ammonium chloride
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeobox protein PITX2; homeodomain transcription factor 2; paired-like homeodomain transcription factor 2; pituitary homeobox 2; Pitx-2; Pitx2c; Ptx2; rPtx2
Orthologs:
Homo sapiens (human) : PITX2 (paired like homeodomain 2)  HGNC  AGR
Mus musculus (house mouse) : Pitx2 (paired-like homeodomain transcription factor 2)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Pitx2 (paired like homeodomain 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PITX2 (paired like homeodomain 2)
Canis lupus familiaris (dog) : PITX2 (paired like homeodomain 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pitx2 (paired like homeodomain 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02233,602,732 - 233,621,059 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02252,929,195 - 252,948,179 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42226,581,170 - 226,601,319 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12226,567,811 - 226,587,999 (+)NCBI
Celera2210,013,296 - 210,033,592 (+)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pitx2
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3331
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-10-31
Status: ACTIVE