Gene: Pitx2 (paired-like homeodomain 2) Rattus norvegicus
Symbol: Pitx2
Name: paired-like homeodomain 2
Description: ENCODES a protein that exhibits RNA polymerase II core promoter proximal region sequence-specific DNA binding; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; chromatin binding (ortholog); INVOLVED IN brain development; female gonad development; male gonad development; PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; ASSOCIATED WITH Hypothyroidism; Polycystic Kidney, Autosomal Dominant; Axenfeld-Rieger Syndrome, Type 1 (ortholog); FOUND IN nucleus; cytoplasm (ortholog); transcription factor complex (ortholog); INTERACTS WITH 1,3-dinitrobenzene; all-trans-retinoic acid; ammonium chloride
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: homeobox protein PITX2; homeodomain transcription factor 2; paired-like homeodomain transcription factor 2; pituitary homeobox 2; Pitx-2; Pitx2c; Ptx2; rPtx2
Latest Assembly: RGSC Genome Assembly v5.0
RGSC Genome Assembly v6.02233,602,732 - 233,621,055+NCBI
Rat Cytogenetic Map2q42 NCBI
RGSC Genome Assembly v5.02252,929,195 - 252,948,179+NCBI
RGSC Genome Assembly v3.42226,581,170 - 226,601,319+NCBI
Rat Celera Assembly2210,013,296 - 210,033,592+NCBI
Genome Assembly 3.12226,567,811 - 226,587,999+NCBI

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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (RGSC Genome Assembly v5.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pitx2
Entrez Gene
Ensembl Gene
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Vista + UCSC

RGD Object Information
RGD ID: 3331
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2016-02-02
Status: ACTIVE