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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 3,4-methylenedioxymethamphetamine | increases expression | ISO | RGD:68591 | 6480464 | N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of DPP6 mRNA | CTD | PMID:20188158 | all-trans-retinoic acid | decreases expression | ISO | RGD:68591 | 6480464 | Tretinoin results in decreased expression of DPP6 mRNA | CTD | PMID:16604517 | benzo[a]pyrene | multiple interactions | ISO | RGD:68591 | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to DPP6 promoter] | CTD | PMID:19654925 | choline | multiple interactions | ISO | RGD:68591 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DPP6 gene | CTD | PMID:20938992 | dichlorine | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] affects the expression of DPP6 mRNA | CTD | PMID:18636392 | folic acid | multiple interactions | ISO | RGD:68591 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DPP6 gene | CTD | PMID:20938992 | L-methionine | multiple interactions | ISO | RGD:68591 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of DPP6 gene | CTD | PMID:20938992 | mono(2-ethylhexyl) phthalate | increases expression | ISO | RGD:68591 | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of DPP6 mRNA | CTD | PMID:22401849 | ozone | multiple interactions | EXP | | 6480464 | [Ozone co-treated with Chlorine] affects the expression of DPP6 mRNA | CTD | PMID:18636392 | paracetamol | multiple interactions | ISO | RGD:68591 | 6480464 | MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of DPP6 mRNA] | CTD | PMID:18700144 | pirimiphos-methyl | decreases activity | EXP | | 6480464 | pirimiphos methyl results in decreased activity of DPP6 protein | CTD | PMID:9204212 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated| 1. |
Alders M, etal., Am J Hum Genet. 2009 Apr;84(4):468-76. Epub 2009 Mar 12. |
| 2. |
Del Bo R, etal., J Neurol Neurosurg Psychiatry. 2008 Sep;79(9):1085. |
| 3. |
Kin Y, etal., J Biochem. 2001 Feb;129(2):289-95. |
| 4. |
Li XG, etal., Chin Med J (Engl). 2009 Dec 20;122(24):2989-92. |
| 5. |
MGD data from the GO Consortium |
| 6. |
Nadal MS, etal., Neuron. 2003 Feb 6;37(3):449-61. |
| 7. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 8. |
RGD automated import pipeline for gene-chemical interactions |
| 9. |
RGD Automated Pipelines |
| 10. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 11. |
van Es MA, etal., Neurology. 2009 Mar 31;72(13):1184-5. |
| 12. |
Wada K, etal., Proc Natl Acad Sci U S A 1992 Jan 1;89(1):197-201. |
References - uncurated| PubMed | 22675523 |
RGD Disease Portals| Dpp6 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Dpp6 (Rattus norvegicus) |
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| DPP6 (Homo sapiens) |
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| Dpp6 (Mus musculus) |
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Position Markers| D4Rat4 |
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| D4Rat139 |
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| D4Arb13 |
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| D4Rat249 |
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| D4Got1 |
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| D4Got2 |
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| D4Got5 |
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| D4Got200 |
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| D5Jcs89 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_022850 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06028640 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06028641 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028642 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028643 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028644 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028645 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028646 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028647 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028648 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028649 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028650 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028651 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028652 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028653 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028654 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028655 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028656 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028657 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028658 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028659 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028660 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028661 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06028662 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027381 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027382 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027383 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027384 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027385 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027386 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027387 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027388 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027389 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027390 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027391 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027392 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027393 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027394 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027395 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027396 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027397 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027398 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027399 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027400 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027401 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027402 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027403 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027404 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027405 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027406 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027407 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01027408 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474057 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M76426 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M76427 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_022850 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_074041 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_074041 | (Get FASTA) |
| GenBank Protein | AAC42061 | (Get FASTA) |
| AAC42062 | (Get FASTA) | |
| EDL86404 | (Get FASTA) | |
| EDL86405 | (Get FASTA) | |
| EDL86406 | (Get FASTA) | |
| EDL86407 | (Get FASTA) | |
| EDL86408 | (Get FASTA) | |
| P46101 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000030547 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000043113 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000045773 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 29272 | ENTREZGENE |
| Germonline | ENSRNOG00000030547 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 22560 | ENTREZGENE |
| InterPro | Peptidase_S9 | UniProtKB/Swiss-Prot |
| Peptidase_S9B | UniProtKB/Swiss-Prot | |
| IPI | IPI00209071 | UniProtKB/Swiss-Prot |
| IPI00231442 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:29272 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | DPPIV_N | UniProtKB/Swiss-Prot |
| Peptidase_S9 | UniProtKB/Swiss-Prot | |
| TIGR | TC239089 | |
| UniGene | Rn.10076 | ENTREZGENE |
| UniProt | DPP6_RAT | UniProtKB/Swiss-Prot |
| F1LMR7_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Dpp6 | dipeptidylpeptidase 6 | Name updated | 1488 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | enriched in brain | 68240 |
| More on Dpp6 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 68402 |
| Created: | 2001-07-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.