RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: pulmonary sarcoidosis
Accession: DOID:13406
browse the term
Definition: A sarcoidosis that is characterized by noncaseating granulomatous infiltration of the lungs and supporting lymph nodes, bilateral hilar adenopathy, and pulmonary issues, has_symptom shortness of breath, fatigue, wheezing, and chronic cough, and develops_from a type IV hypersensitivity reaction. (DO)
Synonyms: exact_synonym: lung sarcoidosis; pulmonary sarcoidoses
primary_id: MESH:D017565
xref: ICD10CM:D86.0 ; NCI:C34997
For additional species annotation, visit the
Alliance of Genome Resources .
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Abo
ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
severity
ISO
RGD
PMID:9036208
RGD:5128833
NCBI chr 3:10,162,087...10,182,835
Ensembl chr 3:10,162,096...10,191,423
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Ada
adenosine deaminase
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:10410539
RGD:5128856
NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088
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Bdnf
brain-derived neurotrophic factor
ISO
RGD
PMID:16315781
RGD:4891110
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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C3
complement C3
ISO
protein:altered expression:lung
RGD
PMID:18069416
RGD:5129502
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Ccl19
C-C motif chemokine ligand 19
ISO
mRNA, protein:increased expression:lung
RGD
PMID:12626344
RGD:5130912
NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
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Ccl5
C-C motif chemokine ligand 5
ISO
mRNA:increased expression:lung:bronchoalveolar lavage cell (human)
RGD
PMID:10384061
RGD:4891436
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Ccr5
C-C motif chemokine receptor 5
disease_progression
ISO
protein:altered expression:lung, lymphocyte, macrophage (human) DNA:polymorphisms:5' utr:multiple (human)
RGD
PMID:11790661 PMID:19679608
RGD:4892099 , RGD:4892066
NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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Ccr7
C-C motif chemokine receptor 7
ISO
mRNA:increased expression:lung
RGD
PMID:12626344
RGD:5130912
NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
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Cftr
CF transmembrane conductance regulator
ISO
DNA:mutations:whole blood :
RGD
PMID:20722470
RGD:4139905
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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Chi3l1
chitinase 3 like 1
ISO
protein:increased secretion:serum (human)
RGD
PMID:15763444
RGD:4892634
NCBI chr13:45,641,802...45,649,787
Ensembl chr13:45,641,802...45,649,787
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Crp
C-reactive protein
severity
ISO
RGD
PMID:21086905
RGD:5131289
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:17550373 PMID:9834133
RGD:5135438 , RGD:5135492
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cxcl11
C-X-C motif chemokine ligand 11
ISO
protein:increased expression:serum
RGD
PMID:17550373
RGD:5135438
NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
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Cxcl6
C-X-C motif chemokine ligand 6
disease_progression
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:17052298
RGD:5135244
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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Cxcl9
C-X-C motif chemokine ligand 9
ISO
protein:increased expression:serum, respiratory system fluid/secretion
RGD
PMID:17550373
RGD:5135438
NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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Cxcr3
C-X-C motif chemokine receptor 3
ISO
protein:increased expression:respiratory system fluid/secretion, T cell
RGD
PMID:9834133
RGD:5135492
NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
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Cyba
cytochrome b-245 alpha chain
no_association
ISO
DNA:SNPs:exons:214C>T (rs4673), 521C>T (rs17845095) (human)
RGD
PMID:16608528
RGD:4780358
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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Defb1
defensin beta 1
ISO
protein:increased expression:serum
RGD
PMID:17000097
RGD:4892262
NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604
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Defb4
defensin beta 4
ISO
protein:increased expression:serum
RGD
PMID:17000097
RGD:4892262
NCBI chr16:70,650,472...70,653,665
Ensembl chr16:70,650,472...70,653,665
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Defb5
defensin beta 5
ISO
protein:increased expression:serum
RGD
PMID:17000097
RGD:4892262
NCBI chr16:70,612,985...70,615,389
Ensembl chr16:70,613,146...70,615,467
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Egr1
early growth response 1
ISO
protein:increased expression:lung (human)
RGD
PMID:16933469
RGD:5131899
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Hmox1
heme oxygenase 1
ISO
protein:increased activity:sputum
RGD
PMID:19453654
RGD:4145349
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Il15
interleukin 15
ISO
mRNA, protein:increased expression:lung
RGD
PMID:11742275
RGD:4990461
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
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Il18
interleukin 18
ISO
protein:increased expression:serum protein:increased expression:bronchoalveolar lavage fluid
RGD
PMID:11174201 PMID:16734560
RGD:4889863 , RGD:4889823
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il18r1
interleukin 18 receptor 1
severity
ISO
RGD
PMID:14641797
RGD:5024944
NCBI chr 9:42,727,416...42,760,971
Ensembl chr 9:42,727,869...42,760,715
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Il1rn
interleukin 1 receptor antagonist
ISO
RGD
PMID:8239179
RGD:4143198
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Lta
lymphotoxin alpha
susceptibility
ISO
DNA:SNP:intron:
RGD
PMID:15713215
RGD:4143248
NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
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Muc1
mucin 1, cell surface associated
ISO
protein:increased expression:serum
RGD
PMID:14665489
RGD:5131177
NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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Ngf
nerve growth factor
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:16315781 PMID:21059230
RGD:4891110 , RGD:5144061
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Nod2
nucleotide-binding oligomerization domain containing 2
disease_progression
ISO
DNA:polymorphism:exon:2104C>T (human)
RGD
PMID:19679608
RGD:4892066
NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
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Nos2
nitric oxide synthase 2
ISO
protein:increased expression:lung
RGD
PMID:11789718
RGD:4891449
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
ISO
protein:increased expression:lung
RGD
PMID:2255800
RGD:4892566
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Ntf3
neurotrophin 3
disease_progression
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:16315781 PMID:21059230
RGD:4891110 , RGD:5144061
NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
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Ntrk1
neurotrophic receptor tyrosine kinase 1
ISO
protein:increased expression: :
RGD
PMID:16315781
RGD:4891110
NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
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RT1-Db1
RT1 class II, locus Db1
severity susceptibility
ISO
DNA:polymorphism:cds:DRB1*03 (human) DNA:polymorphism:cds:DRB1*15 (human)
RGD
PMID:15881283
RGD:40818305
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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Sftpa1
surfactant protein A1
ISO
protein:decreased expression:lung
RGD
PMID:10543276
RGD:4143437
NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
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Tgfb1
transforming growth factor, beta 1
severity
ISO
DNA:polymorphisms: :-509C>T (human)
RGD
PMID:17785866
RGD:4145294
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tlr2
toll-like receptor 2
ISO
mRNA:decreased expression:alveolar macrophage
RGD
PMID:20813038 PMID:23668840
RGD:4145301 , RGD:8553184
NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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Tnc
tenascin C
ISO
protein:increased expression:respiratory system fluid/secretion
RGD
PMID:9780295
RGD:4889595
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
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Tnf
tumor necrosis factor
ISO
DNA:polymorphism:promoter
RGD
PMID:20070603 PMID:15653992
RGD:4143236 , RGD:4143466
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf1b
TNF receptor superfamily member 1B
ISO
protein:increased expression:serum (human)
RGD
PMID:21508170
RGD:5131275
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
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Vip
vasoactive intestinal peptide
ISO
RGD
PMID:20442436
RGD:5685623
NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
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