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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-anisomycin | multiple interactions | ISO | RGD:1314945 | 6480464 | [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA]; more ... | CTD | PMID:22003189 | calcitriol | increases expression | ISO | RGD:1314945 | 6480464 | Calcitriol results in increased expression of NOD2 mRNA | CTD | PMID:16002434 | ciprofloxacin | decreases response to substance | ISO | RGD:1314945 | 6480464 | NOD2 gene SNP results in decreased susceptibility to Ciprofloxacin | CTD | PMID:18371140 | copper(2+) sulfate | decreases expression | ISO | RGD:1314945 | 6480464 | Copper Sulfate results in decreased expression of NOD2 mRNA | CTD | PMID:19549813 | curcumin | multiple interactions | ISO | RGD:1314945 | 6480464 | Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine promotes the reaction [NOD2 protein binds to NOD2 protein]]; more ... | CTD | PMID:18413660 | lauric acid | multiple interactions | ISO | RGD:1314945 | 6480464 | Curcumin inhibits the reaction [lauric acid promotes the reaction [NOD2 protein binds to NOD2 protein]] | CTD | PMID:18413660 | lead diacetate | increases expression | ISO | RGD:1314946 | 6480464 | lead acetate results in increased expression of NOD2 mRNA | CTD | PMID:20542052 | muramyl dipeptide | multiple interactions | ISO | RGD:1314945 | 6480464 | Curcumin inhibits the reaction [Acetylmuramyl-Alanyl-Isoglutamine promotes the reaction [NOD2 protein binds to NOD2 protein]]; more ... | CTD | PMID:18413660 | muramyl dipeptide | multiple interactions | ISO | RGD:1314945 | 6480464 | [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA]; more ... | CTD | PMID:22003189 | rosiglitazone | decreases expression | EXP | | 6480464 | rosiglitazone results in decreased expression of NOD2 mRNA | CTD | PMID:21515302 | troglitazone | decreases expression | EXP | | 6480464 | troglitazone results in decreased expression of NOD2 mRNA | CTD | PMID:21515302 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | NOD-like receptor signaling pathway |
| Tuberculosis | |
| Pathway Interaction Database | Canonical NF-kappaB pathway (PID:200031) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | NOD-like receptor signaling pathway |
| Tuberculosis | |
| Pathway Interaction Database | Canonical NF-kappaB pathway (PID:200031) |
References - curated| 1. |
Austin CM, etal., J Infect Dis. 2008 Jun 15;197(12):1713-6. |
| 2. |
Berrington WR, etal., J Infect Dis. 2010 May 1;201(9):1422-35. |
| 3. |
Biswas A, etal., Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14739-44. Epub 2010 Aug 2. |
| 4. |
Correa-de-Santana E, etal., J Endocrinol. 2009 Oct;203(1):111-22. Epub 2009 Jul 16. |
| 5. |
Duan W, etal., J Allergy Clin Immunol. 2010 Dec;126(6):1284-93.e10. Epub 2010 Nov 4. |
| 6. |
Fernandez EM, etal., Gut. 2011 Aug;60(8):1050-9. Epub 2011 Apr 6. |
| 7. |
Frutuoso MS, etal., Microbes Infect. 2010 Oct;12(11):819-27. Epub 2010 Jun 2. |
| 8. |
Fujisawa M, etal., J Vet Med Sci. 2006 Jul;68(7):701-8. |
| 9. |
Galluzzo S, etal., Hum Immunol. 2011 Aug;72(8):636-40. Epub 2011 Apr 29. |
| 10. |
Geddes K, etal., Infect Immun. 2010 Dec;78(12):5107-15. Epub 2010 Oct 4. |
| 11. |
GOA data from the GO Consortium |
| 12. |
Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1. |
| 13. |
Hagiwara S, etal., J Anesth. 2011 Feb;25(1):57-64. Epub 2010 Nov 6. |
| 14. |
Hagiwara S, etal., Surg Today. 2010;40(2):137-45. Epub 2010 Jan 28. |
| 15. |
Hildebrandt GC, etal., Biol Blood Marrow Transplant. 2008 Jan;14(1):67-74. |
| 16. |
Hnatyszyn A, etal., Exp Mol Pathol. 2010 Jun;88(3):388-93. Epub 2010 Mar 15. |
| 17. |
Hubert FX, etal., J Immunol. 2006 Jul 15;177(2):1007-16. |
| 18. |
Hugot JP, etal., Nature. 2001 May 31;411(6837):599-603. |
| 19. |
Kabesch M, etal., J Allergy Clin Immunol. 2003 Apr;111(4):813-7. |
| 20. |
Kapetanovic R, etal., Microbes Infect. 2010 Sep;12(10):759-67. Epub 2010 May 21. |
| 21. |
Kim YG, etal., Cell Host Microbe. 2011 Jun 16;9(6):496-507. |
| 22. |
Kinose D, etal., Respirology. 2011 Sep 22. doi: 10.1111/j.1440-1843.2011.02069.x. |
| 23. |
Lener MR, etal., Breast Cancer Res Treat. 2006 Jan;95(2):141-5. |
| 24. |
Li H, etal., Eur J Pharmacol. 2010 Dec 15;649(1-3):92-9. Epub 2010 Sep 20. |
| 25. |
Lubinski J, etal., Hered Cancer Clin Pract. 2005 Mar 15;3(2):59-63. |
| 26. |
Mahurkar S, etal., J Gastroenterol Hepatol. 2011 Apr;26(4):694-9. doi: 10.1111/j.1440-1746.2010.06533.x. |
| 27. |
MGD data from the GO Consortium |
| 28. |
Opitz B, etal., J Biol Chem. 2004 Aug 27;279(35):36426-32. Epub 2004 Jun 23. |
| 29. |
Packwood K, etal., Clin Exp Immunol. 2010 Sep;161(3):536-41. doi: 10.1111/j.1365-2249.2010.04216.x. |
| 30. |
Petnicki-Ocwieja T, etal., PLoS One. 2011 Feb 28;6(2):e17414. |
| 31. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 32. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 33. |
Qian M, etal., Pancreas. 2010 Oct;39(7):1034-40. |
| 34. |
RGD automated data pipeline |
| 35. |
RGD automated import pipeline for gene-chemical interactions |
| 36. |
RGD Automated Pipelines |
| 37. |
RGD comprehensive gene curation |
| 38. |
Rivas MA, etal., Nat Genet. 2011 Oct 9. doi: 10.1038/ng.952. |
| 39. |
Rosenzweig HL, etal., Inflamm Res. 2011 Jul;60(7):705-14. Epub 2011 Mar 20. |
| 40. |
Rosenzweig HL, etal., Invest Ophthalmol Vis Sci. 2011 Jun 9;52(7):4106-12. Print 2011 Jun. |
| 41. |
Sato H, etal., Eur Respir J. 2010 Feb;35(2):324-30. Epub 2009 Aug 13. |
| 42. |
Shimada K, etal., PLoS Pathog. 2009 Apr;5(4):e1000379. Epub 2009 Apr 10. |
| 43. |
Su Y, etal., J Neuropathol Exp Neurol. 2005 Nov;64(11):991-7. |
| 44. |
Tekin D, etal., Pediatr Crit Care Med. 2011 Mar 31. |
| 45. |
Weidinger S, etal., Clin Exp Allergy. 2005 Jul;35(7):866-72. |
| 46. |
Yu SL, etal., PLoS One. 2011;6(8):e23855. Epub 2011 Aug 19. |
References - uncurated
RGD Disease Portals| Nod2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Nod2 (Rattus norvegicus) |
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| NOD2 (Homo sapiens) |
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| Nod2 (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001106172 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06097537 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06097538 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06097539 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01097535 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01097536 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01097537 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01097538 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01097539 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01097540 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474037 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001106172 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001099642 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001099642 | (Get FASTA) |
| GenBank Protein | EDL87529 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000014124 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000061463 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000065103 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 291912 | ENTREZGENE |
| Gene3D-CATH | DEATH_like | UniProtKB/TrEMBL |
| HomoloGene Group ID | 11156 | ENTREZGENE |
| InterPro | CARD | UniProtKB/TrEMBL |
| DEATH-like | UniProtKB/TrEMBL | |
| NACHT_NTPase | UniProtKB/TrEMBL | |
| P-loop_NTPase | UniProtKB/TrEMBL | |
| KEGG Report | rno:291912 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | CARD | UniProtKB/TrEMBL |
| PharmGKB | CARD15 | RGD |
| PROSITE | CARD | UniProtKB/TrEMBL |
| NACHT | UniProtKB/TrEMBL | |
| Superfamily-SCOP | DEATH_like | UniProtKB/TrEMBL |
| SSF52540 | UniProtKB/TrEMBL | |
| UniGene | Rn.218600 | ENTREZGENE |
| UniProt | D4A5W3_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2007-12-12 | Nod2 | nucleotide-binding oligomerization domain containing 2 | Card15_predicted | caspase recruitment domain family, member 15 (predicted) | Symbol and Name updated to reflect Human and Mouse nomenclature | 10779 | APPROVED |
| 2005-01-12 | Card15_predicted | caspase recruitment domain family, member 15 (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Nod2 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1306368 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




