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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:homocysteine
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Accession:CHEBI:17230 term browser browse the term
Definition:A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.
Synonyms:related_synonym: 2-Amino-4-mercaptobutyric acid;   2-amino-4-sulfanylbutanoic acid;   Formula=C4H9NO2S;   Hcy;   InChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7);   InChIKey=FFFHZYDWPBMWHY-UHFFFAOYSA-N;   SMILES=NC(CCS)C(O)=O
 alt_id: CHEBI:14408;   CHEBI:5751
 xref: HMDB:HMDB0000742;   KEGG:C05330
 xref_mesh: MESH:D006710
 xref: PMID:11133260;   PMID:16596805;   PMID:18370634;   Wikipedia:Homocysteine
 cyclic_relationship: is_conjugate_acid_of CHEBI:66952;   is_tautomer_of CHEBI:58065


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homocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-Coenzyme A dehydrogenase, medium chain increases expression EXP Homocysteine results in increased expression of ACADM mRNA; Homocysteine results in increased expression of ACADM protein CTD PMID:26993217 NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269 		JBrowse link
G Ache acetylcholinesterase increases activity ISO Homocysteine results in increased activity of ACHE protein CTD PMID:16375580 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions
increases expression		 EXP [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA; [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein]
Homocysteine results in increased expression of ACTA2 mRNA; Homocysteine results in increased expression of ACTA2 protein		 CTD PMID:21647593 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Ahcy S-adenosylhomocysteine hydrolase multiple interactions ISO [Arsenic results in increased expression of and results in increased activity of AHCY protein] which results in increased chemical synthesis of Homocysteine CTD PMID:18487201 NCBI chr 2:154,901,230...154,916,417
Ensembl chr 2:154,901,230...154,916,417 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation		 EXP Atorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of AKT1 protein] CTD PMID:20305681 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alb albumin multiple interactions ISO Folic Acid inhibits the reaction [Homocysteine inhibits the reaction [ALB protein binds to Bilirubin]]; Homocysteine inhibits the reaction [ALB protein binds to Bilirubin] CTD PMID:33788065 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Apoa1 apolipoprotein A-I decreases expression
multiple interactions		 ISO Homocysteine results in decreased expression of APOA1 mRNA; Homocysteine results in decreased expression of APOA1 protein
Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 mRNA]; Homocysteine inhibits the reaction [Simvastatin results in increased expression of APOA1 protein]		 CTD PMID:18540024 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G App amyloid beta precursor protein increases abundance EXP APP protein results in increased abundance of Homocysteine CTD PMID:16837103 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO Homocysteine promotes the reaction [ATF1 protein binds to CCNA2 promoter] CTD PMID:8550827 NCBI chr15:100,125,729...100,159,129
Ensembl chr15:100,125,700...100,159,125 		JBrowse link
G Bax BCL2-associated X protein multiple interactions
affects localization
affects expression
increases expression		 ISO BAX protein inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]]; BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine affects the localization of BAX protein]]; Cystathionine inhibits the reaction [Homocysteine affects the localization of BAX protein]; Cystathionine inhibits the reaction [Homocysteine results in increased expression of and affects the localization of BAX protein]; Folic Acid affects the reaction [Homocysteine affects the expression of BAX mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of BAX protein]; Homocysteine results in increased expression of and affects the localization of BAX protein; Zeranol inhibits the reaction [Homocysteine results in increased expression of BAX protein]
Homocysteine affects the expression of BAX mRNA; Homocysteine affects the expression of BAX protein
Folic Acid inhibits the reaction [Homocysteine results in increased expression of BAX mRNA]		 CTD PMID:16757814 PMID:29250709 PMID:31721048 PMID:31885769 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity		 ISO Folic Acid inhibits the reaction [Homocysteine results in decreased activity of BCHE protein] CTD PMID:16442260 NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
affects expression
decreases expression		 ISO Folic Acid affects the reaction [Homocysteine affects the expression of BCL2 mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of BCL2 protein]; Zeranol inhibits the reaction [Homocysteine results in decreased expression of BCL2 protein]
Homocysteine affects the expression of BCL2 mRNA; Homocysteine affects the expression of BCL2 protein
[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 mRNA; [Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 protein; Folic Acid affects the reaction [[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 mRNA]; Folic Acid affects the reaction [[Homocysteine co-treated with Sodium Glutamate] affects the expression of BCL2 protein]		 CTD PMID:16757814 PMID:22169520 PMID:29250709 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression
multiple interactions		 ISO Homocysteine results in decreased expression of BIRC2 mRNA; Homocysteine results in decreased expression of BIRC2 protein
Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC2 protein]		 CTD PMID:19343037 NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression
multiple interactions		 ISO Homocysteine results in decreased expression of BIRC3 mRNA; Homocysteine results in decreased expression of BIRC3 protein
Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC3 mRNA]; Simvastatin inhibits the reaction [Homocysteine results in decreased expression of BIRC3 protein]		 CTD PMID:19343037 NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187 		JBrowse link
G Cacna2d1 calcium channel, voltage-dependent, alpha2/delta subunit 1 affects binding ISO Homocysteine analog binds to CACNA2D1 protein CTD PMID:16380257 NCBI chr 5:16,139,390...16,579,509
Ensembl chr 5:16,139,786...16,579,502 		JBrowse link
G Calr calreticulin increases expression EXP Homocysteine results in increased expression of CALR mRNA CTD PMID:26993217 NCBI chr 8:85,568,717...85,573,560
Ensembl chr 8:85,568,479...85,573,563 		JBrowse link
G Casp1 caspase 1 multiple interactions
increases activity
increases expression		 EXP [Folic Acid deficiency results in increased abundance of Homocysteine] promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; CASP1 protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; CASP1 protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; PYCARD protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; PYCARD protein affects the reaction [Homocysteine results in increased activity of CASP1 protein]
Homocysteine results in increased expression of CASP1 mRNA		 CTD PMID:22647887 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 multiple interactions
affects cleavage
increases expression
affects expression
increases activity		 ISO
EXP		 BAX protein inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]]; BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased cleavage of CASP3 protein]]; Cystathionine inhibits the reaction [Homocysteine results in increased activity of and results in increased cleavage of CASP3 protein]; Folic Acid affects the reaction [Homocysteine affects the cleavage of CASP3 protein]; Folic Acid affects the reaction [Homocysteine affects the expression of CASP3 mRNA]; Homocysteine results in increased activity of and results in increased cleavage of CASP3 protein; mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]; Simvastatin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]
Folic Acid inhibits the reaction [Homocysteine results in increased expression of CASP3 protein]
Atorvastatin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein]
Homocysteine results in increased expression of CASP3 mRNA; Homocysteine results in increased expression of CASP3 protein		 CTD PMID:16715183 PMID:19343037 PMID:20305681 PMID:21237187 PMID:29250709 More... NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Homocysteine results in increased activity of CASP7 protein
mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP7 protein]		 CTD PMID:21237187 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 multiple interactions
affects expression		 ISO Folic Acid affects the reaction [Homocysteine affects the expression of CASP8 mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of CASP8 protein]
Homocysteine affects the expression of CASP8 mRNA; Homocysteine affects the expression of CASP8 protein		 CTD PMID:29250709 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions		 ISO Homocysteine results in increased activity of CASP9 protein
BTSA1 compound inhibits the reaction [Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP9 protein]]; Cystathionine inhibits the reaction [Homocysteine results in increased activity of CASP9 protein]		 CTD PMID:31885769 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cat catalase decreases transport
multiple interactions
decreases expression		 ISO CAT protein results in decreased transport of Homocysteine
[CAT gene SNP results in increased susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased abundance of Homocysteine
Homocysteine results in decreased expression of CAT protein		 CTD PMID:12631446 PMID:22964297 PMID:30477822 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cbs cystathionine beta-synthase affects abundance
multiple interactions		 EXP
ISO		 CBS protein affects the abundance of Homocysteine; CBS protein affects the abundance of Homocysteine metabolite
Homocysteine inhibits the reaction [Folic Acid results in increased activity of CBS protein]		 CTD PMID:19204075 PMID:23024785 PMID:31721048 NCBI chr17:31,831,602...31,856,170
Ensembl chr17:31,827,868...31,856,212 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO [Homocysteine results in increased expression of CCL2 protein] which results in increased phosphorylation of NFKBIA protein; [Homocysteine results in increased expression of CCL2 protein] which results in increased reduction of NFKBIA mRNA; acetovanillone inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA]; Folic Acid inhibits the reaction [Homocysteine results in increased expression of CCL2 mRNA]
Homocysteine results in increased expression of CCL2 mRNA; Homocysteine results in increased expression of CCL2 protein		 CTD PMID:11356643 PMID:16845898 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
increases expression		 ISO [Homocysteine co-treated with Lipopolysaccharides] results in increased secretion of CCL5 protein
Homocysteine results in increased expression of CCL5 mRNA		 CTD PMID:16225753 NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344 		JBrowse link
G Ccn4 cellular communication network factor 4 decreases expression ISO Homocysteine results in decreased expression of CCN4 mRNA CTD PMID:17320366 NCBI chr15:66,763,337...66,795,050
Ensembl chr15:66,763,169...66,795,050 		JBrowse link
G Ccna1 cyclin A1 multiple interactions
decreases methylation
decreases expression		 ISO DNMT1 protein affects the reaction [Homocysteine results in decreased expression of CCNA1 mRNA]; Homocysteine inhibits the reaction [MECP2 protein binds to CCNA1 promoter]; Homocysteine promotes the reaction [H3-4 protein modified form binds to CCNA1 promoter]; Homocysteine promotes the reaction [H4C16 protein modified form binds to CCNA1 promoter]
Homocysteine results in decreased methylation of CCNA1 promoter		 CTD PMID:17698632 NCBI chr 3:54,952,890...54,965,055
Ensembl chr 3:54,952,890...54,962,922 		JBrowse link
G Ccna2 cyclin A2 multiple interactions
increases expression		 ISO Dactinomycin inhibits the reaction [Homocysteine results in increased expression of CCNA2 mRNA]; Homocysteine promotes the reaction [ATF1 protein binds to CCNA2 promoter]
Homocysteine results in increased expression of CCNA2 mRNA; Homocysteine results in increased expression of CCNA2 protein		 CTD PMID:8550827 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Cdh3 cadherin 3 multiple interactions
decreases expression		 EXP [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA; [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein]
Homocysteine results in decreased expression of CDH3 mRNA; Homocysteine results in decreased expression of CDH3 protein		 CTD PMID:21647593 NCBI chr 8:107,237,484...107,283,543
Ensembl chr 8:107,237,523...107,283,929 		JBrowse link
G Comt catechol-O-methyltransferase multiple interactions ISO [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine] CTD PMID:16758261 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602 		JBrowse link
G Cox5b cytochrome c oxidase subunit 5B multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of COX5B protein CTD PMID:17116298 NCBI chr 1:36,730,568...36,732,469
Ensembl chr 1:36,730,530...36,732,762 		JBrowse link
G Crk v-crk avian sarcoma virus CT10 oncogene homolog multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of CRK protein CTD PMID:17116298 NCBI chr11:75,570,020...75,599,254
Ensembl chr11:75,570,085...75,597,734 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression
multiple interactions
increases secretion		 ISO Homocysteine results in increased expression of CXCL8 mRNA; Homocysteine results in increased expression of CXCL8 protein
[Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Adenosine co-treated with Homocysteine] results in decreased expression of CXCL8 mRNA; Ascorbic Acid affects the reaction [Homocysteine results in increased secretion of CXCL8 protein]; Copper Sulfate promotes the reaction [Homocysteine results in increased expression of CXCL8 mRNA]; Vitamin E affects the reaction [Homocysteine results in increased secretion of CXCL8 protein]		 CTD PMID:12964812 PMID:16715183 PMID:24224954 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cybb cytochrome b-245, beta polypeptide multiple interactions
increases expression
affects localization		 EXP CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of ACTA2 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of CDH3 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB mutant form inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]; CYBB protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; CYBB protein affects the reaction [Homocysteine results in increased abundance of Superoxides]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS1 mRNA]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA]; Filipin inhibits the reaction [Homocysteine affects the localization of CYBB protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine affects the localization of CYBB protein]
Homocysteine results in increased expression of CYBB mRNA; Homocysteine results in increased expression of CYBB protein		 CTD PMID:20036696 PMID:20116427 PMID:21647593 NCBI chr  X:9,301,493...9,354,005
Ensembl chr  X:9,301,491...9,354,010 		JBrowse link
G Ddc dopa decarboxylase multiple interactions ISO [Levodopa co-treated with DDC] results in decreased abundance of Homocysteine CTD PMID:11445284 NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO Glycine inhibits the reaction [Homocysteine results in increased expression of DDIT3 mRNA]; Glycine inhibits the reaction [Homocysteine results in increased expression of DDIT3 protein]
Homocysteine results in increased expression of DDIT3 mRNA; Homocysteine results in increased expression of DDIT3 protein		 CTD PMID:27064126 NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157 		JBrowse link
G Des desmin multiple interactions
increases expression		 EXP [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA; acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; acetovanillone inhibits the reaction [Homocysteine results in increased expression of DES protein]; Amitriptyline inhibits the reaction [Homocysteine results in increased expression of DES protein]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of DES mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased expression of DES protein]; Filipin inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; Filipin inhibits the reaction [Homocysteine results in increased expression of DES protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in increased expression of DES mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in increased expression of DES protein]
Homocysteine results in increased expression of DES mRNA; Homocysteine results in increased expression of DES protein		 CTD PMID:20036696 PMID:20116427 PMID:23024785 NCBI chr 1:75,336,936...75,345,223
Ensembl chr 1:75,336,973...75,345,223 		JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO Homocysteine results in increased expression of and results in increased phosphorylation of DNM1L protein; xestospongin C inhibits the reaction [Homocysteine results in increased expression of and results in increased phosphorylation of DNM1L protein] CTD PMID:33751715 NCBI chr16:16,130,092...16,176,863
Ensembl chr16:16,130,094...16,176,823 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity
multiple interactions		 ISO Homocysteine results in decreased activity of DNMT1 protein
DNMT1 protein affects the reaction [Homocysteine results in decreased expression of CCNA1 mRNA]		 CTD PMID:17698632 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184 		JBrowse link
G Edn1 endothelin 1 multiple interactions
affects expression		 ISO Zeranol inhibits the reaction [Homocysteine affects the expression of EDN1 protein] CTD PMID:16757814 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 decreases phosphorylation ISO Homocysteine results in decreased phosphorylation of EIF2AK3 protein CTD PMID:22964297 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha increases phosphorylation ISO Homocysteine results in increased phosphorylation of EIF2S1 protein CTD PMID:22964297 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784 		JBrowse link
G Ephb6 Eph receptor B6 decreases expression ISO Homocysteine results in decreased expression of EPHB6 mRNA CTD PMID:17320366 NCBI chr 6:41,581,940...41,597,445
Ensembl chr 6:41,582,416...41,597,443 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signalling 1 decreases phosphorylation ISO Homocysteine results in decreased phosphorylation of ERN1 protein CTD PMID:22964297 NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha decreases expression ISO Homocysteine results in decreased expression of ERO1A protein CTD PMID:22964297 NCBI chr14:45,520,544...45,556,029
Ensembl chr14:45,520,544...45,556,228 		JBrowse link
G Exosc4 exosome component 4 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of EXOSC4 protein CTD PMID:17116298 NCBI chr15:76,211,597...76,214,870
Ensembl chr15:76,211,597...76,214,877 		JBrowse link
G Gata4 GATA binding protein 4 decreases expression
multiple interactions		 ISO Homocysteine results in decreased expression of GATA4 mRNA; Homocysteine results in decreased expression of GATA4 protein
Particulate Matter promotes the reaction [Homocysteine results in decreased expression of GATA4 protein]		 CTD PMID:27203204 NCBI chr14:63,436,363...63,509,161
Ensembl chr14:63,436,371...63,509,141 		JBrowse link
G Gh growth hormone decreases abundance ISO GH1 protein results in decreased abundance of Homocysteine CTD PMID:17311540 PMID:17324600 NCBI chr11:106,191,087...106,194,529
Ensembl chr11:106,191,097...106,192,691 		JBrowse link
G Gpt glutamic pyruvic transaminase, soluble increases activity
multiple interactions		 ISO Homocysteine results in increased activity of GPT protein
Folic Acid inhibits the reaction [Homocysteine results in increased activity of GPT protein]		 CTD PMID:33788065 NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity
decreases expression		 ISO Homocysteine results in decreased activity of GPX1 protein
Homocysteine results in decreased expression of GPX1 protein		 CTD PMID:15734734 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) increases expression ISO Homocysteine analog results in increased expression of GRIN1 protein CTD PMID:20406136 NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199 		JBrowse link
G Gsr glutathione reductase decreases expression ISO Homocysteine results in decreased expression of GSR protein CTD PMID:22964297 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of GSTM3 protein CTD PMID:17116298 NCBI chr 3:107,803,240...107,806,002
Ensembl chr 3:107,803,137...107,806,002 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions ISO [GSTP1 gene SNP results in increased susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased abundance of Homocysteine CTD PMID:30477822 NCBI chr19:4,085,411...4,087,912
Ensembl chr19:4,085,407...4,087,985 		JBrowse link
G H3f4 H3.4 histone, cluster member multiple interactions ISO Homocysteine promotes the reaction [H3-4 protein modified form binds to CCNA1 promoter] CTD PMID:17698632 NCBI chr11:58,852,537...58,853,099
Ensembl chr11:58,852,599...58,853,364 		JBrowse link
G H4c16 H4 histone 16 multiple interactions ISO Homocysteine promotes the reaction [H4C16 protein modified form binds to CCNA1 promoter] CTD PMID:17698632 NCBI chr 6:136,780,991...136,781,429
Ensembl chr 6:136,778,551...136,781,413 		JBrowse link
G Hspa5 heat shock protein 5 multiple interactions
increases expression		 ISO Glycine inhibits the reaction [Homocysteine results in increased expression of HSPA5 mRNA]
Homocysteine results in increased expression of HSPA5 mRNA; Homocysteine results in increased expression of HSPA5 protein		 CTD PMID:19960509 PMID:27064126 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Hspa9 heat shock protein 9 multiple interactions ISO Homocysteine promotes the reaction [HSPA9 protein binds to ITPR1 protein]; Homocysteine promotes the reaction [HSPA9 protein binds to VDAC1 protein] CTD PMID:33751715 NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410 		JBrowse link
G Ins1 insulin I multiple interactions ISO [Alloxan co-treated with Homocysteine] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Homocysteine inhibits the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:27317948 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Isl1 ISL1 transcription factor, LIM/homeodomain affects expression
multiple interactions		 EXP Homocysteine affects the expression of ISL1 mRNA
Folic Acid inhibits the reaction [Homocysteine affects the expression of ISL1 mRNA]; Inositol promotes the reaction [Folic Acid inhibits the reaction [Homocysteine affects the expression of ISL1 mRNA]]		 CTD PMID:19638421 NCBI chr13:116,434,806...116,446,224
Ensembl chr13:116,434,817...116,446,225 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 multiple interactions
increases expression		 ISO Homocysteine promotes the reaction [HSPA9 protein binds to ITPR1 protein]
Homocysteine results in increased expression of ITPR1 protein		 CTD PMID:33751715 NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 increases expression ISO Homocysteine results in increased expression of KEAP1 protein CTD PMID:22964297 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Genistein] inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Genistein inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Genistein inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]]; Go 6976 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Phorbol 12,13-Dibutyrate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Phorbol 12,13-Dibutyrate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]
6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; alpha-methyl-4-carboxyphenylglycine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:16251475 PMID:19850060 PMID:25888188 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 multiple interactions
increases phosphorylation		 ISO
EXP		 Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; Atorvastatin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; NOX4 mutant form inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein] CTD PMID:19767766 PMID:20018284 PMID:20305681 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; [1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester co-treated with Genistein] inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]]; Acetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Genistein inhibits the reaction [Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]]; Go 6976 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Phorbol 12,13-Dibutyrate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Phorbol 12,13-Dibutyrate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Tetradecanoylphorbol Acetate promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Thapsigargin promotes the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]
6-Cyano-7-nitroquinoxaline-2,3-dione inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; 6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; alpha-methyl-4-carboxyphenylglycine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; Dizocilpine Maleate inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein]		 CTD PMID:16251475 PMID:19850060 PMID:25888188 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO Homocysteine results in increased phosphorylation of MAPK8 protein
fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK8 protein]		 CTD PMID:25888188 NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions		 ISO Homocysteine results in increased phosphorylation of MAPK9 protein
fulvic acid inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK9 protein]		 CTD PMID:25888188 NCBI chr11:49,737,558...49,777,248
Ensembl chr11:49,737,578...49,777,248 		JBrowse link
G Mcu mitochondrial calcium uniporter increases expression ISO Homocysteine results in increased expression of MCU protein CTD PMID:33751715 NCBI chr10:59,282,806...59,453,231
Ensembl chr10:59,282,806...59,452,514 		JBrowse link
G Mecp2 methyl CpG binding protein 2 multiple interactions ISO Homocysteine inhibits the reaction [MECP2 protein binds to CCNA1 promoter] CTD PMID:17698632 NCBI chr  X:73,070,198...73,129,296
Ensembl chr  X:73,070,198...73,129,296 		JBrowse link
G Mfn2 mitofusin 2 decreases expression ISO Homocysteine results in decreased expression of MFN2 protein CTD PMID:33751715 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein]; Homocysteine analog results in decreased expression of and results in decreased activity of MMP1 protein CTD PMID:20406136 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
increases expression
increases activity		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]
Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of MMP9 protein]
Homocysteine results in increased activity of and results in increased expression of MMP9 protein		 CTD PMID:16251475 PMID:20406136 PMID:22326992 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases expression
multiple interactions
affects abundance
decreases methylation
increases abundance
affects metabolic processing		 ISO
EXP		 Homocysteine results in increased expression of MTHFR protein
[MTHFR gene mutant form co-treated with Methotrexate] results in increased abundance of Homocysteine
MTHFR protein affects the abundance of Homocysteine metabolite
Homocysteine inhibits the reaction [Simvastatin results in increased expression of MTHFR protein modified form]; Simvastatin promotes the reaction [Homocysteine results in increased expression of MTHFR protein]
MTHFR protein SNP results in decreased methylation of Homocysteine
MTHFR gene polymorphism results in increased abundance of Homocysteine; MTHFR protein mutant form results in increased abundance of Homocysteine
MTHFR protein affects the metabolism of Homocysteine		 CTD PMID:7647779 PMID:17387702 PMID:18540024 PMID:19204075 PMID:19593106 More... NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase affects metabolic processing
multiple interactions
affects binding		 ISO MTR gene polymorphism affects the metabolism of Homocysteine
Homocysteine inhibits the reaction [Folic Acid results in increased activity of MTR protein]
Homocysteine binds to MTR protein		 CTD PMID:17477549 PMID:20532609 PMID:31721048 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase affects abundance EXP MTRR protein affects the abundance of Homocysteine CTD PMID:17369066 NCBI chr13:68,708,897...68,730,273
Ensembl chr13:68,708,899...68,730,268 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 affects localization
increases phosphorylation
multiple interactions		 ISO
EXP		 Homocysteine affects the localization of NCF1 protein
Homocysteine results in increased phosphorylation of NCF1 protein
Filipin inhibits the reaction [Homocysteine affects the localization of NCF1 protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine affects the localization of NCF1 protein]
Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of NCF1 protein]; Homocysteine promotes the reaction [NCF1 protein results in increased abundance of Reactive Oxygen Species]; Homocysteine results in increased localization of and results in increased activity of NCF1 protein		 CTD PMID:16845898 PMID:17586618 PMID:20036696 NCBI chr 5:134,248,907...134,258,479
Ensembl chr 5:134,248,907...134,258,479 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization
multiple interactions
increases expression		 ISO
EXP		 Homocysteine affects the localization of NFE2L2 protein modified form
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Homocysteine results in decreased expression of NFE2L2 protein]; Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein; L 709049 inhibits the reaction [Homocysteine results in decreased expression of NFE2L2 protein]; N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal inhibits the reaction [Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein]; Homocysteine results in decreased phosphorylation of and results in decreased expression of NFE2L2 protein
Homocysteine results in increased expression of NFE2L2 mRNA		 CTD PMID:22964297 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions
increases degradation		 ISO [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] results in decreased expression of NFKBIA mRNA; [Homocysteine results in increased expression of CCL2 protein] which results in increased phosphorylation of NFKBIA protein; [Homocysteine results in increased expression of CCL2 protein] which results in increased reduction of NFKBIA mRNA; acetovanillone inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein]; Folic Acid inhibits the reaction [Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein]; Homocysteine results in increased phosphorylation of and results in increased activity of NFKBIA protein
Homocysteine results in increased degradation of NFKBIA protein		 CTD PMID:11356643 PMID:16845898 PMID:17586618 PMID:24224954 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta increases degradation ISO Homocysteine results in increased degradation of NFKBIB protein CTD PMID:17586618 NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937 		JBrowse link
G Nkx2-5 NK2 homeobox 5 multiple interactions
decreases expression		 ISO Particulate Matter promotes the reaction [Homocysteine results in decreased expression of NKX2-5 protein]
Homocysteine results in decreased expression of NKX2-5 mRNA; Homocysteine results in decreased expression of NKX2-5 protein		 CTD PMID:27203204 NCBI chr17:27,057,638...27,063,962
Ensembl chr17:27,057,638...27,063,983 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 multiple interactions
increases expression		 EXP [Folic Acid deficiency results in increased abundance of Homocysteine] promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; CASP1 protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; PYCARD protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]
Homocysteine results in increased expression of NLRC3 mRNA		 CTD PMID:22647887 NCBI chr16:3,762,871...3,796,881
Ensembl chr16:3,762,871...3,794,496 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases methylation
increases expression
multiple interactions		 ISO
EXP		 Homocysteine results in increased methylation of NOS2 promoter
Homocysteine results in increased expression of NOS2 mRNA
Homocysteine affects the reaction [Simvastatin results in increased expression of NOS2 protein]; Simvastatin promotes the reaction [Homocysteine results in increased expression of NOS2 mRNA]
[Homocysteine results in increased methylation of NOS2 promoter] which results in decreased expression of NOS2 mRNA; Clofibrate inhibits the reaction [Homocysteine results in increased methylation of NOS2 promoter]; pioglitazone inhibits the reaction [Homocysteine results in increased methylation of NOS2 promoter]		 CTD PMID:17492134 PMID:18540024 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions
decreases expression
decreases phosphorylation		 ISO
EXP		 Folic Acid inhibits the reaction [Homocysteine results in decreased expression of and results in decreased activity of NOS3 protein]; Homocysteine results in decreased expression of and results in decreased activity of NOS3 protein; Zeranol inhibits the reaction [Homocysteine results in decreased expression of NOS3 protein]
Homocysteine results in decreased expression of NOS3 mRNA; Homocysteine results in decreased expression of NOS3 protein
Homocysteine results in decreased phosphorylation of NOS3 protein
Atorvastatin inhibits the reaction [Homocysteine results in decreased expression of NOS3 mRNA]; Atorvastatin inhibits the reaction [Homocysteine results in decreased phosphorylation of NOS3 protein]		 CTD PMID:16757814 PMID:17357445 PMID:20305681 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions
increases response to substance
increases expression		 ISO Atorvastatin inhibits the reaction [Homocysteine results in increased expression of NOX4 mRNA]; NOX4 mutant form inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]
NOX4 results in increased susceptibility to Homocysteine		 CTD PMID:20018284 NCBI chr 7:86,893,638...87,047,918
Ensembl chr 7:86,895,304...87,047,918 		JBrowse link
G Nphs2 nephrosis 2, podocin multiple interactions
decreases expression		 EXP [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; Amitriptyline inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; Filipin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 mRNA]; methyl-beta-cyclodextrin inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein]
Homocysteine results in decreased expression of NPHS2 mRNA; Homocysteine results in decreased expression of NPHS2 protein		 CTD PMID:20036696 PMID:20116427 PMID:23024785 NCBI chr 1:156,138,105...156,155,605
Ensembl chr 1:156,138,297...156,155,605 		JBrowse link
G Nt5e 5' nucleotidase, ecto affects activity EXP Homocysteine affects the activity of NT5E protein CTD PMID:24055814 NCBI chr 9:88,209,662...88,254,142
Ensembl chr 9:88,209,250...88,254,145 		JBrowse link
G Pacs2 phosphofurin acidic cluster sorting protein 2 increases expression ISO Homocysteine results in increased expression of PACS2 protein CTD PMID:33751715 NCBI chr12:112,977,998...113,038,021
Ensembl chr12:112,978,128...113,038,021 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions EXP [Methionine results in increased abundance of Homocysteine] which results in decreased activity of PON1 protein; [resveratrol results in increased abundance of Homocysteine] which results in decreased activity of PON1 protein CTD PMID:19028542 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946 		JBrowse link
G Prdx6 peroxiredoxin 6 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of PRDX6 protein CTD PMID:17116298 NCBI chr 1:161,067,682...161,078,780
Ensembl chr 1:161,067,682...161,078,789 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; fulvic acid inhibits the reaction [Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]]; fulvic acid inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]; pyrazolanthrone inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA]; SN50 peptide inhibits the reaction [Homocysteine results in increased expression of PTGS2 mRNA] CTD PMID:25888188 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions
increases expression		 EXP [Folic Acid deficiency results in increased abundance of Homocysteine] promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; CASP1 protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]; PYCARD protein affects the reaction [Homocysteine promotes the reaction [NLRC3 protein binds to PYCARD protein binds to CASP1 protein]]; PYCARD protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; PYCARD protein affects the reaction [Homocysteine results in increased activity of CASP1 protein]
Homocysteine results in increased expression of PYCARD mRNA		 CTD PMID:22647887 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Rab1b RAB1B, member RAS oncogene family multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of RAB1B protein CTD PMID:17116298 NCBI chr19:5,149,235...5,157,024
Ensembl chr19:5,149,233...5,157,100 		JBrowse link
G Rab9 RAB9, member RAS oncogene family multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of RAB9A protein CTD PMID:17116298 NCBI chr  X:165,240,247...165,262,863
Ensembl chr  X:165,240,249...165,262,863 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions
increases expression
increases localization
increases activity		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased activity of RELA protein]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; fulvic acid inhibits the reaction [Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]]; Homocysteine promotes the reaction [RELA protein binds to PTGS2 promoter]; pyrazolanthrone inhibits the reaction [Homocysteine results in increased activity of RELA protein]
Homocysteine results in increased expression of RELA protein
Homocysteine inhibits the reaction [Simvastatin results in decreased expression of RELA protein]
Homocysteine results in increased localization of RELA protein		 CTD PMID:17586618 PMID:18540024 PMID:24224954 PMID:25888188 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 multiple interactions ISO [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein CTD PMID:24224954 NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130 		JBrowse link
G S100a4 S100 calcium binding protein A4 multiple interactions
increases expression		 EXP [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA; [Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein; acetovanillone inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 mRNA]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in increased expression of S100A4 protein]; CYBB mutant form inhibits the reaction [Homocysteine results in increased expression of S100A4 protein]
Homocysteine results in increased expression of S100A4 mRNA; Homocysteine results in increased expression of S100A4 protein		 CTD PMID:21647593 NCBI chr 3:90,511,077...90,513,349
Ensembl chr 3:90,511,078...90,513,352 		JBrowse link
G Slc46a1 solute carrier family 46, member 1 affects abundance EXP SLC46A1 protein affects the abundance of Homocysteine metabolite CTD PMID:19204075 NCBI chr11:78,356,527...78,362,771
Ensembl chr11:78,356,523...78,362,885 		JBrowse link
G Sod1 superoxide dismutase 1, soluble increases expression ISO Homocysteine results in increased expression of SOD1 protein CTD PMID:17485853 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions ISO [SOD2 gene SNP results in increased susceptibility to [Air Pollutants results in increased abundance of Particulate Matter]] which results in increased abundance of Homocysteine CTD PMID:30477822 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Ssr4 signal sequence receptor, delta multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of SSR4 protein CTD PMID:17116298 NCBI chr  X:72,830,778...72,834,432
Ensembl chr  X:72,830,634...72,834,436 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions
increases expression		 ISO Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 mRNA]; Dizocilpine Maleate inhibits the reaction [Homocysteine analog results in increased expression of TIMP1 protein]
Homocysteine analog results in increased expression of TIMP1 mRNA; Homocysteine analog results in increased expression of TIMP1 protein		 CTD PMID:20406136 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
decreases expression		 EXP [Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA; acetovanillone inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]; CYBB mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of TJP1 mRNA]; CYBB mutant form inhibits the reaction [Homocysteine results in decreased expression of TJP1 protein]
Homocysteine results in decreased expression of TJP1 mRNA; Homocysteine results in decreased expression of TJP1 protein		 CTD PMID:21647593 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO [Adenosine co-treated with Homocysteine co-treated with TNF protein] results in increased cleavage of RIPK1 protein; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein affects the localization of RELA protein modified form]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; [Adenosine co-treated with Homocysteine] affects the reaction [TNF protein results in increased phosphorylation of RELA protein]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in increased susceptibility to TNF protein
Homocysteine results in increased expression of TNF protein		 CTD PMID:24224954 PMID:27203204 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 multiple interactions ISO [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 mRNA]; [Adenosine co-treated with Homocysteine] inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 mRNA; [Adenosine co-treated with Homocysteine] results in decreased expression of TNFAIP3 protein CTD PMID:24224954 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405 		JBrowse link
G Trp53 transformation related protein 53 increases phosphorylation
affects expression
multiple interactions		 ISO Homocysteine results in increased phosphorylation of TP53 protein
Homocysteine affects the expression of TP53 mRNA; Homocysteine affects the expression of TP53 protein
Folic Acid affects the reaction [Homocysteine affects the expression of TP53 mRNA]; Folic Acid affects the reaction [Homocysteine affects the expression of TP53 protein]		 CTD PMID:13679428 PMID:29250709 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Vbp1 von Hippel-Lindau binding protein 1 multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of VBP1 protein CTD PMID:17116298 NCBI chr  X:74,557,903...74,578,552
Ensembl chr  X:74,557,905...74,578,548 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
increases expression		 ISO 3,4-dihydroxyphenylethanol inhibits the reaction [Homocysteine results in increased expression of VCAM1 protein]; resveratrol inhibits the reaction [Homocysteine results in increased expression of VCAM1 protein]
Homocysteine results in increased expression of VCAM1 mRNA; Homocysteine results in increased expression of VCAM1 protein		 CTD PMID:17586618 NCBI chr 3:115,903,669...115,923,337
Ensembl chr 3:115,903,598...115,923,337 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 increases expression
multiple interactions		 ISO Homocysteine results in increased expression of VDAC1 protein
Homocysteine promotes the reaction [HSPA9 protein binds to VDAC1 protein]		 CTD PMID:33751715 NCBI chr11:52,251,905...52,280,224
Ensembl chr11:52,251,687...52,280,224 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression
decreases expression
decreases secretion		 EXP
ISO		 Amitriptyline inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein]; CASP1 protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; CYBB protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]; diphenyleneiodonium inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein]; Homocysteine results in decreased expression of and results in decreased secretion of VEGFA protein; PYCARD protein affects the reaction [Homocysteine results in decreased secretion of VEGFA protein]
Homocysteine results in increased expression of VEGFA protein
Homocysteine results in decreased expression of VEGFA mRNA		 CTD PMID:17485853 PMID:20116427 PMID:22647887 PMID:23024785 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vim vimentin increases expression ISO Homocysteine results in increased expression of VIM protein CTD PMID:17485853 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
G Vps29 VPS29 retromer complex component multiple interactions ISO [Methionine deficiency co-treated with Homocysteine] affects the expression of VPS29 protein CTD PMID:17116298 NCBI chr 5:122,492,391...122,503,047
Ensembl chr 5:122,492,432...122,503,047 		JBrowse link
G Wnt5a wingless-type MMTV integration site family, member 5A decreases expression ISO Homocysteine results in decreased expression of WNT5A mRNA CTD PMID:17320366 NCBI chr14:28,224,962...28,249,405
Ensembl chr14:28,226,707...28,249,405 		JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
decreases expression
increases expression
increases splicing		 ISO Glycine affects the reaction [Homocysteine results in increased splicing of XBP1 mRNA]
Homocysteine results in decreased expression of XBP1 protein
Homocysteine results in increased expression of XBP1 mRNA alternative form		 CTD PMID:19960509 PMID:22964297 PMID:27064126 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893 		JBrowse link
homocysteic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha multiple interactions ISO [homocysteic acid co-treated with GW 506033X] results in increased phosphorylation of EIF2S1 protein CTD PMID:19046382 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784 		JBrowse link
G Hsf1 heat shock factor 1 decreases expression ISO homocysteic acid results in decreased expression of HSF1 protein CTD PMID:24478344 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113 		JBrowse link
G Sp1 trans-acting transcription factor 1 increases activity
multiple interactions		 ISO homocysteic acid results in increased activity of SP1 protein
mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP1 protein]		 CTD PMID:11261509 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839 		JBrowse link
G Sp3 trans-acting transcription factor 3 multiple interactions
increases activity		 ISO mithramycin A inhibits the reaction [homocysteic acid results in increased activity of SP3 protein] CTD PMID:11261509 NCBI chr 2:72,766,774...72,810,790
Ensembl chr 2:72,766,771...72,810,790 		JBrowse link
S-adenosyl-L-homocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy S-adenosylhomocysteine hydrolase increases hydrolysis ISO AHCY results in increased hydrolysis of S-Adenosylhomocysteine CTD PMID:26974671 NCBI chr 2:154,901,230...154,916,417
Ensembl chr 2:154,901,230...154,916,417 		JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
increases abundance		 EXP PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine] CTD PMID:29416063 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Alas2 aminolevulinic acid synthase 2, erythroid multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:149,330,443...149,353,614
Ensembl chr  X:149,330,371...149,353,634 		JBrowse link
G App amyloid beta precursor protein increases expression
decreases methylation
multiple interactions		 EXP S-Adenosylhomocysteine results in increased expression of APP protein
S-Adenosylhomocysteine results in decreased methylation of APP promoter
Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein]; S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein		 CTD PMID:19635394 PMID:22064374 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Atp7b ATPase, Cu++ transporting, beta polypeptide increases abundance EXP ATP7B protein mutant form results in increased abundance of S-Adenosylhomocysteine CTD PMID:22945834 NCBI chr 8:22,482,799...22,550,347
Ensembl chr 8:22,482,801...22,550,321 		JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 increases expression EXP S-Adenosylhomocysteine results in increased expression of BACE1 protein CTD PMID:19635394 NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697 		JBrowse link
G Carm1 coactivator-associated arginine methyltransferase 1 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of CARM1 protein CTD PMID:33577917 NCBI chr 9:21,458,163...21,500,763
Ensembl chr 9:21,458,190...21,503,919 		JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression ISO S-Adenosylhomocysteine results in decreased expression of COL1A1 mRNA CTD PMID:15983038 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Col1a2 collagen, type I, alpha 2 decreases expression ISO S-Adenosylhomocysteine results in decreased expression of COL1A2 mRNA CTD PMID:15983038 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544 		JBrowse link
G Comt catechol-O-methyltransferase decreases activity ISO S-Adenosylhomocysteine results in decreased activity of COMT protein CTD PMID:10064789 NCBI chr16:18,225,632...18,247,006
Ensembl chr16:18,225,636...18,245,602 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity
multiple interactions		 ISO
EXP		 S-Adenosylhomocysteine results in decreased activity of DNMT1 protein
S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]		 CTD PMID:16037419 PMID:22064374 NCBI chr 9:20,818,501...20,871,084
Ensembl chr 9:20,818,505...20,871,184 		JBrowse link
G Fgf15 fibroblast growth factor 15 decreases abundance EXP FGF19 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690 		JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029
G Hmbs hydroxymethylbilane synthase multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr 9:44,247,645...44,255,525
Ensembl chr 9:44,247,636...44,255,525 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions		 EXP
ISO		 S-Adenosylhomocysteine results in increased expression of MMP2 mRNA; S-Adenosylhomocysteine results in increased expression of MMP2 protein
S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter]
U 0126 inhibits the reaction [S-Adenosylhomocysteine results in increased expression of MMP2 protein]		 CTD PMID:19770485 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases expression ISO S-Adenosylhomocysteine results in decreased expression of NFKBIA protein CTD PMID:19770485 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases abundance EXP NR0B2 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847 		JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 multiple interactions
decreases methylation
decreases expression		 EXP Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased expression of OGG1 protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of OGG1 promoter]; S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
S-Adenosylhomocysteine results in decreased expression of OGG1 mRNA; S-Adenosylhomocysteine results in decreased expression of OGG1 protein		 CTD PMID:22064374 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions EXP PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine] CTD PMID:29416063 NCBI chr11:59,861,440...59,937,394
Ensembl chr11:59,861,440...59,937,315 		JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO S-Adenosylhomocysteine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068 		JBrowse link
G Prmt1 protein arginine N-methyltransferase 1 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT1 protein CTD PMID:33577917 NCBI chr 7:44,626,179...44,635,844
Ensembl chr 7:44,625,413...44,635,992 		JBrowse link
G Prmt5 protein arginine N-methyltransferase 5 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT5 protein CTD PMID:33577917 NCBI chr14:54,744,639...54,754,927
Ensembl chr14:54,744,644...54,754,982 		JBrowse link
G Prmt6 protein arginine N-methyltransferase 6 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT6 protein CTD PMID:33577917 NCBI chr 3:110,153,420...110,158,315
Ensembl chr 3:110,153,425...110,158,314 		JBrowse link
G Prmt7 protein arginine N-methyltransferase 7 decreases activity ISO S-Adenosylhomocysteine results in decreased activity of PRMT7 protein CTD PMID:33577917 NCBI chr 8:106,937,686...106,978,326
Ensembl chr 8:106,937,568...106,979,426 		JBrowse link
G Psen1 presenilin 1 multiple interactions
decreases methylation
increases expression		 EXP Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of PSEN1 promoter]
S-Adenosylhomocysteine results in increased expression of PSEN1 protein		 CTD PMID:19635394 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
G Slc19a1 solute carrier family 19 (folate transporter), member 1 affects abundance EXP SLC19A1 protein affects the abundance of S-Adenosylhomocysteine CTD PMID:15705887 NCBI chr10:76,868,103...76,886,266
Ensembl chr10:76,868,075...76,896,836 		JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions ISO S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter] CTD PMID:19770485 NCBI chr15:102,314,751...102,344,839
Ensembl chr15:102,314,578...102,344,839 		JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 decreases expression EXP S-Adenosylhomocysteine results in decreased expression of TIMP2 protein CTD PMID:19770485 NCBI chr11:118,191,887...118,246,237
Ensembl chr11:118,191,887...118,246,566 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        biochemical role 21454
          metabolite 21402
            fundamental metabolite 15008
              homocysteine 138
                L-homocysteine + 0
                homocysteic acid + 4
                homocysteine derivative + 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    main group molecular entity 22120
                      s-block molecular entity 21721
                        hydrogen molecular entity 21639
                          hydrides 20777
                            inorganic hydride 18691
                              pnictogen hydride 18671
                                nitrogen hydride 18540
                                  azane 18447
                                    ammonia 18446
                                      organic amino compound 18446
                                        amino acid 16432
                                          non-proteinogenic amino acid 4038
                                            non-proteinogenic alpha-amino acid 3839
                                              homocysteines 440
                                                homocysteine 138
                                                  L-homocysteine + 0
                                                  homocysteic acid + 4
                                                  homocysteine derivative + 28
paths to the root