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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619565
Species: Mus musculus
RGD Object: Gene
Symbol: Mapk14
Name: mitogen-activated protein kinase 14
Acc ID: CHEBI:17230
Term: homocysteine
Definition: A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.
Chemical ID: MESH:D006710
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk14increases phosphorylationEXP 6480464CTDHomocysteine results in increased phosphorylation of MAPK14 proteinPMID:20305681
Mapk14multiple interactionsEXP 6480464CTDAtorvastatin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]PMID:20305681
Mapk14increases phosphorylationISOMAPK14 (Homo sapiens)6480464CTDHomocysteine results in increased phosphorylation of MAPK14 proteinPMID:19767766 PMID:20018284
Mapk14multiple interactionsISOMAPK14 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; Atorvastatin inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; diphenyleneiodonium inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; NOX4 mutant form inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]; SB 203580 inhibits the reaction [Homocysteine results in increased phosphorylation of MAPK14 protein]PMID:19767766 PMID:20018284
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