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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:sulindac sulfone
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Accession:CHEBI:64212 term browser browse the term
Definition:A sulfone metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. It inhibits the development and induces regression of premalignant adenomatous polyps. Lipoxygenase and Cox-2 inhibitor.
Synonyms:exact_synonym: {(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfonyl)benzylidene]-1H-inden-3-yl}acetic acid
 related_synonym: 5-Fluoro-2-methyl-1-((Z)-p-(methylsulfonyl)benzylidene)indene-3-acetic acid;   Formula=C20H17FO4S;   InChI=1S/C20H17FO4S/c1-12-17(9-13-3-6-15(7-4-13)26(2,24)25)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-;   InChIKey=MVGSNCBCUWPVDA-MFOYZWKCSA-N;   SMILES=CC1=C(CC(O)=O)c2cc(F)ccc2C\\1=C/c1ccc(cc1)S(C)(=O)=O;   cis-5-Fluoro-2-methyl-1-(p-methylsulfonylbenzylidenyl)indene-3-acetic acid;   exisulind
 xref: CAS:59973-80-7;   Drug_Central:3219
 xref_mesh: MESH:C025463
 xref: PMID:17016604;   PMID:20332437;   PMID:20374023;   PMID:21515355;   PMID:21735687;   PMID:22364235;   Patent:EP1336602;   Patent:US5696159;   Patent:US5776962;   Reaxys:7887099;   Wikipedia:Exisulind


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sulindac sulfone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B1 multiple interactions ISO sulindac sulfone binds to and results in decreased activity of AKR1B1 protein CTD PMID:25532697 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 multiple interactions ISO sulindac sulfone binds to and results in decreased activity of AKR1B10 protein CTD PMID:25532697 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation
multiple interactions		 ISO
EXP		 sulindac sulfone affects the phosphorylation of AKT1 protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of AKT1 protein modified form		 CTD PMID:15570007 PMID:17908994 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions
increases expression		 ISO 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphorothioate inhibits the reaction [sulindac sulfone results in increased phosphorylation of ALOX15 protein]; GATA6 protein inhibits the reaction [sulindac sulfone results in increased expression of ALOX15 protein]
sulindac sulfone results in increased expression of ALOX15 mRNA; sulindac sulfone results in increased expression of ALOX15 protein		 CTD PMID:11861401 PMID:16166323 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Ar androgen receptor multiple interactions ISO
EXP		 AR protein affects the reaction [sulindac sulfone results in decreased expression of KLK3 protein]; sulindac sulfone results in decreased expression of and results in decreased activity of AR protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of AR protein		 CTD PMID:14581372 PMID:17908994 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases response to substance EXP BAK1 results in increased susceptibility to sulindac sulfone CTD PMID:18349538 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein]; sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein
sulindac sulfone results in increased activity of CASP3 protein		 CTD PMID:11051267 PMID:14555707 PMID:15548677 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 increases activity ISO sulindac sulfone results in increased activity of CASP8 protein CTD PMID:11559570 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO
EXP		 sulindac sulfone results in decreased expression of CCND1 mRNA; sulindac sulfone results in decreased expression of CCND1 protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of CCND1 protein		 CTD PMID:12392815 PMID:15188006 PMID:17908994 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO sulindac sulfone results in increased expression of CDKN1A mRNA; sulindac sulfone results in increased expression of CDKN1A protein CTD PMID:18593937 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO sulindac sulfone results in increased expression of CDKN1B mRNA; sulindac sulfone results in increased expression of CDKN1B protein CTD PMID:18593937 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
increases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of CTNNB1 protein]
sulindac sulfone results in increased expression of CTNNB1 protein		 CTD PMID:10910034 PMID:11602670 PMID:12392815 PMID:14555707 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
decreases phosphorylation
increases phosphorylation
increases ubiquitination		 ISO
EXP		 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]
sulindac sulfone results in decreased phosphorylation of EGFR protein
sulindac sulfone results in increased phosphorylation of EGFR protein
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein; [Celecoxib co-treated with sulindac sulfone] results in decreased expression of EGFR protein modified form
sulindac sulfone results in increased ubiquitination of EGFR protein		 CTD PMID:17908994 PMID:20332299 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression ISO sulindac sulfone results in decreased expression of ERBB2 protein CTD PMID:20332299 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sulindac sulfone results in decreased expression of ERBB3 protein] CTD PMID:20332299 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO sulindac sulfone results in decreased expression of ESR1 mRNA; sulindac sulfone results in decreased expression of ESR1 protein CTD PMID:16740773 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gata6 GATA binding protein 6 multiple interactions
decreases expression		 ISO GATA6 protein inhibits the reaction [sulindac sulfone results in increased expression of ALOX15 protein]
sulindac sulfone results in decreased expression of GATA6 protein		 CTD PMID:11861401 NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO sulindac sulfone binds to and results in decreased activity of GSTP1 protein CTD PMID:15300575 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 increases expression ISO sulindac sulfone results in increased expression of HINT1 mRNA; sulindac sulfone results in increased expression of HINT1 protein CTD PMID:18593937 NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases activity
increases expression		 ISO sulindac sulfone results in increased activity of HPGD protein
sulindac sulfone results in increased expression of HPGD mRNA		 CTD PMID:19501039 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Il24 interleukin 24 increases expression ISO sulindac sulfone results in increased expression of IL24 protein CTD PMID:15713900 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions
decreases expression		 ISO AR protein affects the reaction [sulindac sulfone results in decreased expression of KLK3 protein] CTD PMID:11490238 PMID:14581372 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK1 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK3 protein]; MAP2K1 protein inhibits the reaction [sulindac sulfone results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:15548677 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO sulindac sulfone results in increased phosphorylation of and results in increased activity of MAP2K4 protein CTD PMID:11051267 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK1 protein] CTD PMID:15548677 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO MAP2K1 protein inhibits the reaction [sulindac sulfone results in decreased phosphorylation of MAPK3 protein] CTD PMID:15548677 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO sulindac sulfone results in increased activity of MAPK8 protein CTD PMID:11051267 PMID:11278263 PMID:15970671 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO sulindac sulfone results in decreased expression of MMP7 protein CTD PMID:15725655 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO sulindac sulfone results in increased degradation of and results in decreased expression of NFKBIA protein CTD PMID:18059344 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngfr nerve growth factor receptor increases expression ISO sulindac sulfone results in increased expression of NGFR mRNA; sulindac sulfone results in increased expression of NGFR protein CTD PMID:17447067 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression		 ISO sulindac sulfone results in increased activity of NQO1 protein
sulindac sulfone results in increased expression of NQO1 mRNA		 CTD PMID:17985343 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO sulindac sulfone results in decreased expression of PCNA protein CTD PMID:15570007 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pde2a phosphodiesterase 2A decreases activity
multiple interactions		 ISO sulindac sulfone results in decreased activity of PDE2A protein
sulindac sulfone binds to and results in decreased activity of PDE2A protein		 CTD PMID:10910034 PMID:11602670 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434 		JBrowse link
G Pde5a phosphodiesterase 5A multiple interactions
decreases activity		 ISO sulindac sulfone binds to and results in decreased activity of PDE5A protein
sulindac sulfone results in decreased activity of PDE5A protein		 CTD PMID:10910034 PMID:11602670 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pgr progesterone receptor decreases expression ISO sulindac sulfone results in decreased expression of PGR mRNA; sulindac sulfone results in decreased expression of PGR protein CTD PMID:16740773 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression ISO sulindac sulfone results in increased expression of PPARA mRNA CTD PMID:11948457 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO sulindac sulfone results in increased expression of PPARD mRNA CTD PMID:11948457 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO [sulindac sulfone results in increased activity of PPARG protein] promotes the reaction [PPARG protein binds to SAT1 enhancer]; PPARG protein promotes the reaction [sulindac sulfone results in increased expression of SAT1 mRNA]
sulindac sulfone results in increased expression of PPARG mRNA		 CTD PMID:11948457 PMID:14506281 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 increases expression ISO sulindac sulfone results in increased expression of PRKG1 protein CTD PMID:11602670 PMID:16731751 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Psca prostate stem cell antigen increases expression ISO sulindac sulfone results in increased expression of PSCA mRNA CTD PMID:16949054 NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression EXP sulindac sulfone results in decreased expression of PTGS1 mRNA alternative form CTD PMID:11375891 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression
increases expression
multiple interactions		 ISO
EXP		 sulindac sulfone results in decreased expression of PTGS2 protein
sulindac sulfone results in increased expression of PTGS2 mRNA
[sulindac sulfone results in decreased expression of PTGS2 protein] which results in decreased chemical synthesis of Dinoprostone
[Celecoxib co-treated with sulindac sulfone] results in decreased expression of PTGS2 protein; Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of PTGS2 protein]
sulindac sulfone results in decreased expression of PTGS2 mRNA		 CTD PMID:11118042 PMID:11375891 PMID:11948457 PMID:17908994 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO sulindac sulfone affects the localization of RELA protein CTD PMID:18059344 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 multiple interactions
increases expression		 ISO [sulindac sulfone results in increased activity of PPARG protein] promotes the reaction [PPARG protein binds to SAT1 enhancer]; PPARG protein promotes the reaction [sulindac sulfone results in increased expression of SAT1 mRNA] CTD PMID:14506281 PMID:16262603 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Celecoxib promotes the reaction [sulindac sulfone results in decreased expression of TNF protein] CTD PMID:17908994 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases activity
increases expression
increases glucuronidation		 ISO sulindac sulfone results in increased activity of UGT1A1 protein
sulindac sulfone results in increased expression of UGT1A1 mRNA
UGT1A1 protein results in increased glucuronidation of sulindac sulfone		 CTD PMID:15843492 PMID:17985343 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of sulindac sulfone CTD PMID:15843492 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of sulindac sulfone CTD PMID:15843492 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of sulindac sulfone CTD PMID:15843492 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation ISO sulindac sulfone results in increased phosphorylation of VASP protein CTD PMID:16166323 NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061 		JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon decreases expression ISO sulindac sulfone results in decreased expression of YWHAE protein CTD PMID:17409426 NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        biochemical role 19496
          apoptosis inducer 13624
            sulindac sulfone 51
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      monocarboxylic acid 17984
                                        acetic acid 11045
                                          sulindac 785
                                            sulindac sulfone 51
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