(-)-citrinin - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	(-)-citrinin	go back to main search page
Accession:	CHEBI:48707	browse the term
Definition:	A citrinin that has formula C13H14O5.
Synonyms:	exact_synonym:	(3R,4S)-8-hydroxy-3,4,5-trimethyl-6-oxo-4,6-dihydro-3H-isochromene-7-carboxylic acid
	related_synonym:	(3R,4S)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid; (3R-trans)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid; Formula=C13H14O5; InChI=1S/C13H14O5/c1-5-7(3)18-4-8-9(5)6(2)11(14)10(12(8)15)13(16)17/h4-5,7,15H,1-3H3,(H,16,17)/t5-,7-/m1/s1; InChIKey=CQIUKKVOEOPUDV-IYSWYEEDSA-N; SMILES=C[C@H]1OC=C2C(O)=C(C(O)=O)C(=O)C(C)=C2[C@@H]1C
	xref:	Beilstein:5282243; Beilstein:88597; CAS:518-75-2; KEGG:C16765; KNApSAcK:C00029979
	xref_mesh:	MESH:D002953
	cyclic_relationship:	is_enantiomer_of CHEBI:48712

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Genes (98)

(-)-citrinin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions

[ochratoxin A co-treated with Citrinin] results in increased expression of ACTA2 mRNA; [ochratoxin A co-treated with Citrinin] results in increased expression of ACTA2 protein

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

activating transcription factor 3

increases expression

Citrinin results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 4

increases expression

Citrinin results in increased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

autophagy related 5

increases expression

Citrinin results in increased expression of ATG5 mRNA

NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209

G

BAG cochaperone 3

increases expression
multiple interactions

Citrinin results in increased expression of BAG3 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of BAG3 mRNA; [Citrinin co-treated with ochratoxin A] results in increased expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

BCL2-antagonist/killer 1

increases expression
multiple interactions

Citrinin results in increased expression of BAK1 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of BAK1 mRNA

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

increases expression
affects expression

Citrinin results in increased expression of BAX protein
Citrinin affects the expression of BAX protein

PMID:21622943 PMID:22771370

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
affects expression

Citrinin results in decreased expression of BCL2 protein
Citrinin affects the expression of BCL2 protein

PMID:21622943 PMID:22771370

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2 like 12

increases expression
multiple interactions

Citrinin results in increased expression of BCL2L12 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of BCL2L12 mRNA

NCBI chr 1:95,472,272...95,480,991
Ensembl chr 1:95,472,272...95,480,991

G

beclin 1

increases expression

Citrinin results in increased expression of BECN1 mRNA

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

caspase 2

decreases expression
multiple interactions

Citrinin results in decreased expression of CASP2 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CASP2 mRNA

NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379

G

caspase 3

increases activity
increases expression
multiple interactions

Citrinin results in increased activity of CASP3 protein
Citrinin results in increased expression of CASP3 protein modified form
[Citrinin results in increased activity of CASP3 protein] which results in increased activity of PAK2 protein; Citrinin results in increased activity of CASP3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Citrinin results in increased activity of CASP3 protein]; Citrinin inhibits the reaction [ochratoxin A results in increased activity of CASP3 protein]; pyrazolanthrone inhibits the reaction [Citrinin results in increased activity of CASP3 protein]

PMID:18767140 PMID:19361540 PMID:21622943 PMID:22564900 PMID:29673704

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity
increases expression

Citrinin results in increased activity of CASP9 protein
Citrinin results in increased expression of CASP9 protein modified form

PMID:21622943 PMID:22564900

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

increases activity

Citrinin results in increased activity of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin A2

increases expression

Citrinin results in increased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

increases expression
multiple interactions
decreases expression

Citrinin results in increased expression of CCNB1 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CCNB1 mRNA
Citrinin results in decreased expression of CCNB1 mRNA

PMID:23856526 PMID:30428381

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin E1

increases expression
decreases expression
multiple interactions

Citrinin results in increased expression of CCNE1 mRNA
Citrinin results in decreased expression of CCNE1 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CCNE1 mRNA

PMID:23856526 PMID:30428381

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin G1

multiple interactions

[Citrinin co-treated with ochratoxin A] results in decreased expression of CCNG1 mRNA; [Citrinin co-treated with ochratoxin A] results in decreased expression of CCNG1 protein

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

cell division cycle 23

decreases expression
multiple interactions

Citrinin results in decreased expression of CDC23 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CDC23 mRNA

NCBI chr18:26,236,891...26,260,611
Ensembl chr18:26,236,890...26,291,163

G

cell division cycle 25A

multiple interactions
increases expression
decreases expression

[Citrinin co-treated with ochratoxin A] results in decreased expression of CDC25A mRNA
Citrinin results in increased expression of CDC25A mRNA
Citrinin results in decreased expression of CDC25A mRNA

NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701

G

cell division cycle 25C

multiple interactions
decreases expression

[Citrinin co-treated with ochratoxin A] results in decreased expression of CDC25C mRNA
Citrinin results in decreased expression of CDC25C mRNA

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 26

multiple interactions
decreases expression

[Citrinin co-treated with ochratoxin A] results in decreased expression of CDC26 mRNA
Citrinin results in decreased expression of CDC26 mRNA

NCBI chr 5:75,844,852...75,859,830

G

cell division cycle 34, ubiqiutin conjugating enzyme

multiple interactions
decreases expression

[Citrinin co-treated with ochratoxin A] results in decreased expression of CDC34 mRNA
Citrinin results in decreased expression of CDC34 mRNA

NCBI chr 7:10,017,588...10,023,586
Ensembl chr 7:10,017,588...10,023,186

G

cell division cycle 6

multiple interactions
decreases expression

[Citrinin co-treated with ochratoxin A] results in decreased expression of CDC6 mRNA
Citrinin results in decreased expression of CDC6 mRNA

NCBI chr10:83,864,189...83,878,011
Ensembl chr10:83,864,638...83,878,011

G

cell division cycle 7

decreases expression
multiple interactions

Citrinin results in decreased expression of CDC7 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CDC7 mRNA

NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778

G

cadherin 1

multiple interactions

[Citrinin co-treated with ochratoxin A] results in decreased expression of CDH1 mRNA; [ochratoxin A co-treated with Citrinin] results in decreased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin-dependent kinase 1

decreases expression
multiple interactions

Citrinin results in decreased expression of CDK1 protein modified form
[Citrinin co-treated with ochratoxin A] results in decreased expression of CDK1 mRNA

PMID:20929984 PMID:30428381

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 10

multiple interactions

[Citrinin co-treated with ochratoxin A] results in decreased expression of CDK10 mRNA

NCBI chr19:51,260,012...51,273,009
Ensembl chr19:51,261,356...51,269,078

G

cyclin-dependent kinase inhibitor 1A

increases expression

Citrinin results in increased expression of CDKN1A protein

PMID:20929984 PMID:21622943

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

decreases expression
multiple interactions

Citrinin results in decreased expression of CDKN1B mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of CDKN1B mRNA; [Citrinin co-treated with ochratoxin A] results in increased expression of CDKN1B mRNA

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

collagen type III alpha 1 chain

multiple interactions

[Citrinin co-treated with ochratoxin A] results in decreased expression of COL3A1 mRNA; [Citrinin co-treated with ochratoxin A] results in increased expression of and results in increased secretion of COL3A1 protein

NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547

G

cytochrome c, somatic

affects localization

Citrinin affects the localization of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression

Citrinin results in decreased expression of CYP11A1 protein

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

DNA-damage inducible transcript 3

increases expression

Citrinin results in increased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

E2F transcription factor 1

increases expression

Citrinin results in increased expression of E2F1 mRNA

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

early growth response 1

increases expression
multiple interactions

Citrinin results in increased expression of EGR1 mRNA; Citrinin results in increased expression of EGR1 protein
U 0126 inhibits the reaction [Citrinin results in increased expression of EGR1 protein]

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Citrinin results in increased expression of FOS mRNA; Citrinin results in increased expression of FOS protein
U 0126 inhibits the reaction [Citrinin results in increased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

growth arrest and DNA-damage-inducible, beta

increases expression
multiple interactions

Citrinin results in increased expression of GADD45B mRNA
U 0126 inhibits the reaction [Citrinin results in increased expression of GADD45B mRNA]

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

hepatocyte growth factor

increases expression

Citrinin results in increased expression of HGF mRNA

NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409

G

heme oxygenase 1

increases expression

Citrinin results in increased expression of HMOX1; Citrinin results in increased expression of HMOX1 mRNA

PMID:26260164 PMID:36460223

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression

Citrinin results in decreased expression of HSD3B1 protein

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

interferon gamma

decreases expression
decreases secretion
increases expression

Citrinin results in decreased expression of IFNG mRNA
Citrinin results in decreased secretion of IFNG protein
Citrinin results in increased expression of IFNG protein

PMID:12112629 PMID:22771370

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

multiple interactions

Citrinin inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]; Citrinin inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL10 mRNA]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL10 protein]; Citrinin inhibits the reaction [Zymosan results in increased expression of IL10 mRNA]; Citrinin inhibits the reaction [Zymosan results in increased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions
decreases expression

Citrinin inhibits the reaction [Poly I-C results in increased expression of IL1B mRNA]; Citrinin inhibits the reaction [Zymosan results in increased expression of IL1B mRNA]
Citrinin results in decreased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

Citrinin results in increased expression of JUN mRNA; Citrinin results in increased expression of JUN protein

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

Citrinin results in increased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

lipocalin 2

increases expression

Citrinin results in increased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

Citrinin results in increased phosphorylation of MAPK1 protein
Citrinin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK1 protein]; ochratoxin A promotes the reaction [Citrinin results in increased phosphorylation of MAPK1 protein]

PMID:19361540 PMID:23856526 PMID:29673704

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation
multiple interactions

Citrinin results in increased phosphorylation of MAPK3 protein
Citrinin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK3 protein]; ochratoxin A promotes the reaction [Citrinin results in increased phosphorylation of MAPK3 protein]

PMID:19361540 PMID:23856526 PMID:29673704

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

increases phosphorylation

Citrinin results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

increases phosphorylation

Citrinin results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microRNA 1

decreases expression
multiple interactions

Citrinin results in decreased expression of MIR1 mRNA
[Citrinin co-treated with ochratoxin A] results in increased expression of MIR1 mRNA

NCBI chr18:1,887,537...1,887,623

G

microRNA 107

decreases expression

Citrinin results in decreased expression of MIR107 mRNA

NCBI chr 1:232,337,767...232,337,853
Ensembl chr 1:232,337,767...232,337,853

G

microRNA 122

multiple interactions
increases expression

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR122 mRNA
Citrinin results in increased expression of MIR122 mRNA

NCBI chr18:58,758,703...58,758,787

G

microRNA 132

multiple interactions

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR132 mRNA

NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796

G

microRNA 139

multiple interactions

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR139 mRNA

NCBI chr 1:155,878,828...155,878,895
Ensembl chr 1:155,878,825...155,878,902

G

microRNA 142

multiple interactions

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR142 mRNA

NCBI chr10:72,557,864...72,557,950
Ensembl chr10:72,557,857...72,557,967

G

microRNA 144

multiple interactions

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR144 mRNA

NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430

G

microRNA 152

multiple interactions

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR152 mRNA

NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020

G

microRNA 184

multiple interactions

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR184 mRNA

NCBI chr 8:90,343,134...90,343,210
Ensembl chr 8:90,343,134...90,343,210

G

microRNA 187

multiple interactions

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR187 mRNA

NCBI chr18:15,731,194...15,731,297
Ensembl chr18:15,731,194...15,731,297

G

microRNA 190b

multiple interactions

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR190B mRNA

NCBI chr 2:175,514,800...175,514,877
Ensembl chr 2:175,514,800...175,514,877

G

microRNA 200b

multiple interactions

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR200B mRNA

NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366

G

microRNA 200c

multiple interactions

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR200C mRNA

NCBI chr 4:157,523,679...157,523,747

G

microRNA 295-1

multiple interactions

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR372 mRNA

NCBI chr 1:65,962,566...65,962,646
Ensembl chr 1:65,962,566...65,962,646

G

microRNA 301a

decreases expression

Citrinin results in decreased expression of MIR301A mRNA

NCBI chr10:71,925,336...71,925,435
Ensembl chr10:71,925,336...71,925,435

G

microRNA 32

decreases expression

Citrinin results in decreased expression of MIR32 mRNA

NCBI chr 5:71,596,083...71,596,152
Ensembl chr 5:71,596,083...71,596,152

G

microRNA 34a

decreases expression

Citrinin results in decreased expression of MIR34A mRNA

NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103

G

microRNA 34b

multiple interactions
decreases expression

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR34B mRNA
Citrinin results in decreased expression of MIR34B mRNA

NCBI chr 8:51,410,244...51,410,327
Ensembl chr 8:51,410,244...51,410,327

G

microRNA 34c

decreases expression
multiple interactions

Citrinin results in decreased expression of MIR34C mRNA
[Citrinin co-treated with ochratoxin A] results in increased expression of MIR34C mRNA

NCBI chr 8:51,409,726...51,409,802
Ensembl chr 8:51,409,726...51,409,802

G

microRNA 374b

decreases expression

Citrinin results in decreased expression of MIR374B mRNA

NCBI chr X:68,591,732...68,591,799
Ensembl chr X:68,591,732...68,591,799

G

microRNA 449a

multiple interactions

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR449A mRNA

NCBI chr 2:44,670,714...44,670,804
Ensembl chr 2:44,670,714...44,670,804

G

microRNA 449c

multiple interactions

[Citrinin co-treated with ochratoxin A] results in increased expression of MIR449C mRNA

NCBI chr 2:44,669,179...44,669,277
Ensembl chr 2:44,669,179...44,669,277

G

microRNA 92a-1

decreases expression

Citrinin results in decreased expression of MIR92A1 mRNA

NCBI chr15:92,181,336...92,181,413
Ensembl chr15:92,181,336...92,181,413

G

matrix metallopeptidase 3

increases expression
multiple interactions

Citrinin results in increased expression of MMP3 mRNA
pyrazolanthrone inhibits the reaction [Citrinin results in increased expression of MMP3 mRNA]

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

NAD(P)H quinone dehydrogenase 1

increases expression

Citrinin results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

netrin G2

decreases expression

Citrinin results in decreased expression of NTNG2 mRNA

NCBI chr 3:12,492,574...12,551,104
Ensembl chr 3:12,492,639...12,545,890

G

p21 (RAC1) activated kinase 2

increases activity

[Citrinin results in increased activity of CASP3 protein] which results in increased activity of PAK2 protein; Citrinin results in increased activity of PAK2 protein

NCBI chr11:68,707,940...68,768,816
Ensembl chr11:68,707,969...68,768,816

G

programmed cell death 4

multiple interactions
decreases expression

[Citrinin co-treated with ochratoxin A] results in decreased expression of PDCD4 mRNA
Citrinin results in decreased expression of PDCD4 mRNA

NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275

G

plexin A4

decreases expression

Citrinin results in decreased expression of PLXNA4 mRNA

NCBI chr 4:60,720,246...61,162,206
Ensembl chr 4:60,720,255...61,162,206

G

peroxisome proliferator-activated receptor gamma

decreases activity

Citrinin results in decreased activity of PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 1, regulatory subunit 15A

increases expression

Citrinin results in increased expression of PPP1R15A mRNA

NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[ochratoxin A co-treated with Citrinin] results in decreased expression of PTGS2 mRNA; [ochratoxin A co-treated with Citrinin] results in decreased expression of PTGS2 protein

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

roundabout guidance receptor 2

decreases expression

Citrinin results in decreased expression of ROBO2 mRNA

NCBI chr11:12,528,949...14,096,726
Ensembl chr11:12,528,951...13,041,536

G

semaphorin 3F

decreases expression

Citrinin results in decreased expression of SEMA3F mRNA

NCBI chr 8:108,357,629...108,386,569
Ensembl chr 8:108,357,629...108,387,083

G

solute carrier family 22 member 6

multiple interactions

Citrinin inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 5 member 1

multiple interactions

[Citrinin co-treated with ochratoxin A] results in decreased expression of SLC5A1 mRNA

NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547

G

steroidogenic acute regulatory protein

decreases expression

Citrinin results in decreased expression of STAR protein

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

thyroid hormone receptor beta

multiple interactions

[Citrinin co-treated with ochratoxin A] results in decreased activity of THRB protein

NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916

G

toll-like receptor 2

increases expression

Citrinin results in increased expression of TLR2 mRNA

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 3

decreases expression

Citrinin results in decreased expression of TLR3 mRNA

NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545

G

tumor necrosis factor

multiple interactions

Citrinin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Citrinin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Citrinin inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Citrinin promotes the reaction [CPG-oligonucleotide results in increased expression of TNF mRNA]; Citrinin promotes the reaction [CPG-oligonucleotide results in increased expression of TNF protein]
[ochratoxin A co-treated with Citrinin] results in increased expression of TNF mRNA; [ochratoxin A co-treated with Citrinin] results in increased expression of TNF protein; pyrazolanthrone inhibits the reaction [[ochratoxin A co-treated with Citrinin] results in increased expression of TNF mRNA]; U 0126 inhibits the reaction [[ochratoxin A co-treated with Citrinin] results in increased expression of TNF mRNA]

PMID:22771370 PMID:29673704

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 1

increases expression
multiple interactions

Citrinin results in increased expression of TNFAIP1 mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of TNFAIP1 mRNA

NCBI chr10:63,417,774...63,432,466
Ensembl chr10:63,417,775...63,432,466

G

TNF receptor superfamily member 12A

increases expression
multiple interactions

Citrinin results in increased expression of TNFRSF12A mRNA
[Citrinin co-treated with ochratoxin A] results in decreased expression of TNFRSF12A mRNA

NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045

G

TNF receptor superfamily member 1A

multiple interactions

[Citrinin co-treated with ochratoxin A] results in decreased expression of TNFRSF1A mRNA

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

tumor protein p53

increases expression

Citrinin results in increased expression of TP53 protein
Citrinin results in increased expression of TRP53 protein
Citrinin results in increased expression of TP53 protein modified form

PMID:20929984 PMID:21622943 PMID:22564900

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tubulin, beta 3 class III

decreases expression

Citrinin results in decreased expression of TUBB3 mRNA

NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243

G

vimentin

multiple interactions

[ochratoxin A co-treated with Citrinin] results in decreased expression of VIM mRNA; [ochratoxin A co-treated with Citrinin] results in increased expression of VIM protein

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19808
role	19784
biological role	19782
biochemical role	19496
metabolite	19484
eukaryotic metabolite	19307
fungal metabolite	17857
Penicillium metabolite	2105
(-)-citrinin	98
Path 2
Term	Annotations
CHEBI ontology	19808
subatomic particle	19806
composite particle	19806
hadron	19806
baryon	19806
nucleon	19806
atomic nucleus	19806
atom	19806
main group element atom	19756
main group molecular entity	19756
p-block molecular entity	19756
carbon group molecular entity	19705
organic molecular entity	19702
organic molecule	19655
organic cyclic compound	19468
organic heterocyclic compound	18848
organic heteropolycyclic compound	18278
benzopyran	11952
2-benzopyran	1468
isochromenes	1468
8-hydroxy-3,4,5-trimethyl-6-oxo-4,6-dihydro-3H-isochromene-7-carboxylic acid	98
citrinin	98
(-)-citrinin	98

paths to the root