Mir187 (microRNA 187) - Rat Genome Database

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Pathways
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Gene: Mir187 (microRNA 187) Rattus norvegicus
Analyze
Symbol: Mir187
Name: microRNA 187
RGD ID: 2325557
Description: Predicted to enable mRNA base-pairing translational repressor activity. Predicted to be involved in cellular response to lipopolysaccharide; miRNA-mediated post-transcriptional gene silencing; and negative regulation of inflammatory response. Predicted to act upstream of or within long-term synaptic potentiation. Orthologous to human MIR187 (microRNA 187); INTERACTS WITH cadmium atom; cadmium dichloride; furan.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-187; rno-mir-187
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81816,005,947 - 16,006,050 (-)NCBIGRCr8
mRatBN7.21815,731,194 - 15,731,297 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1815,731,194 - 15,731,297 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1815,917,755 - 15,917,858 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01816,700,461 - 16,700,564 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01815,997,000 - 15,997,103 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01816,390,507 - 16,390,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1816,390,507 - 16,390,610 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01816,149,604 - 16,149,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1815,667,176 - 15,667,279 (-)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Up-regulation of miR-187 modulates the advances of oral carcinoma by targeting BARX2 tumor suppressor. Lin SC, etal., Oncotarget. 2016 Sep 20;7(38):61355-61365. doi: 10.18632/oncotarget.11349.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:20403161   PMID:25858512   PMID:26463627   PMID:27609046   PMID:28562528   PMID:30170060   PMID:31302329   PMID:31786333   PMID:32705147   PMID:32934961  
PMID:34015413  


Genomics

Comparative Map Data
Mir187
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81816,005,947 - 16,006,050 (-)NCBIGRCr8
mRatBN7.21815,731,194 - 15,731,297 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1815,731,194 - 15,731,297 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1815,917,755 - 15,917,858 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01816,700,461 - 16,700,564 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01815,997,000 - 15,997,103 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01816,390,507 - 16,390,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1816,390,507 - 16,390,610 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01816,149,604 - 16,149,707 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1815,667,176 - 15,667,279 (-)NCBICelera
Cytogenetic Map18p12NCBI
MIR187
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381835,904,818 - 35,904,926 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1835,904,818 - 35,904,926 (-)EnsemblGRCh38hg38GRCh38
GRCh371833,484,781 - 33,484,889 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361831,738,778 - 31,738,886 (-)NCBINCBI36Build 36hg18NCBI36
Celera1830,292,723 - 30,292,831 (-)NCBICelera
Cytogenetic Map18q12.2NCBI
HuRef1830,343,311 - 30,343,419 (-)NCBIHuRef
CHM1_11833,411,788 - 33,411,896 (-)NCBICHM1_1
T2T-CHM13v2.01836,096,332 - 36,096,440 (-)NCBIT2T-CHM13v2.0
Mir187
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391824,562,167 - 24,562,227 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1824,562,167 - 24,562,227 (-)EnsemblGRCm39 Ensembl
GRCm381824,429,110 - 24,429,170 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1824,429,110 - 24,429,170 (-)EnsemblGRCm38mm10GRCm38
MGSCv371824,587,611 - 24,587,671 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1824,917,551 - 24,917,611 (-)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1813.17NCBI
MIR187
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1754,261,943 - 54,262,010 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl754,261,943 - 54,262,010 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha753,687,475 - 53,687,542 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0754,232,783 - 54,232,850 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl754,232,783 - 54,232,850 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1753,915,888 - 53,915,955 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0753,938,933 - 53,939,000 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0754,231,787 - 54,231,854 (+)NCBIUU_Cfam_GSD_1.0
MIR187
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.16119,674,881 - 119,674,958 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26112,191,797 - 112,191,874 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:8153
Count of gene targets:5267
Count of transcripts:5699
Interacting mature miRNAs:rno-miR-187-3p, rno-miR-187-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18224947722066430Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181194429924797117Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 7 12 5 1 3 1
Below cutoff 1 3 1 1 4 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000053644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1815,731,194 - 15,731,297 (-)Ensembl
Rnor_6.0 Ensembl1816,390,507 - 16,390,610 (-)Ensembl
RefSeq Acc Id: NR_031905
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81816,005,947 - 16,006,050 (-)NCBI
mRatBN7.21815,731,194 - 15,731,297 (-)NCBI
Rnor_6.01816,390,507 - 16,390,610 (-)NCBI
Rnor_5.01816,149,604 - 16,149,707 (-)NCBI
Celera1815,667,176 - 15,667,279 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325557 AgrOrtholog
BioCyc Gene G2FUF-8152 BioCyc
Ensembl Genes ENSRNOG00000035521 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053644 ENTREZGENE
miRBase MI0000932 ENTREZGENE
NCBI Gene 100314044 ENTREZGENE
PhenoGen Mir187 PhenoGen
RatGTEx ENSRNOG00000035521 RatGTEx
RNAcentral URS00001EB9FC RNACentral
  URS00006FB978 RNACentral
  URS000075F0FF RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir187  microRNA 187  Mir187  microRNA mir-187  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir187  microRNA mir-187      Symbol and Name status set to provisional 70820 PROVISIONAL