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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-ethylmaleimide
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Accession:CHEBI:44485 term browser browse the term
Definition:A member of the class of maleimides that is the N-ethyl derivative of maleimide.
Synonyms:related_synonym: 1-ethyl-1H-pyrrole-2,5-dione;   Ethylmaleimide;   Formula=C6H7NO2;   InChI=1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3;   InChIKey=HDFGOPSGAURCEO-UHFFFAOYSA-N;   NEM;   SMILES=CCN1C(=O)C=CC1=O
 alt_id: CHEBI:44483;   CHEBI:7269
 xref: Beilstein:112448;   CAS:128-53-0;   DrugBank:DB02967;   Gmelin:405614;   KEGG:C02441;   LINCS:LSM-4219
 xref_mesh: MESH:D005033
 xref: MetaCyc:N-ETHYLMALEIMIDE;   PDBeChem:NEQ;   PMID:12232209;   PMID:18499511;   PMID:24211707;   PMID:6501266;   Reaxys:112448;   Wikipedia:N-Ethylmaleimide


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N-ethylmaleimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO Ethylmaleimide results in decreased activity of ABCB1 protein CTD PMID:2900677 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 affects activity
multiple interactions		 ISO Ethylmaleimide affects the activity of ABCC1 protein
Ethylmaleimide inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]		 CTD PMID:9096673 PMID:9334814 PMID:16101123 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases activity EXP Ethylmaleimide results in decreased activity of ACSL4 protein CTD PMID:11319222 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Alb albumin decreases transport EXP Ethylmaleimide results in decreased transport of ALB protein CTD PMID:15897811 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions
increases glutathionylation		 ISO Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein] CTD PMID:20566629 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 multiple interactions EXP Ethylmaleimide inhibits the reaction [ATP8B1 protein results in increased transport of Phosphatidylserines] CTD PMID:11584374 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396 		JBrowse link
G Cbr2 carbonyl reductase 2 increases acylation ISO Ethylmaleimide results in increased acylation of CBR2 protein CTD PMID:18597497 NCBI chr10:106,008,535...106,012,838
Ensembl chr10:105,991,589...106,013,001 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions ISO Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein] CTD PMID:15657297 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Chat choline O-acetyltransferase decreases activity ISO Ethylmaleimide results in decreased activity of CHAT protein CTD PMID:3437937 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Ethylmaleimide inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein] CTD PMID:10820281 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Dusp23 dual specificity phosphatase 23 multiple interactions ISO Ethylmaleimide inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] CTD PMID:15147733 NCBI chr13:85,097,899...85,100,054
Ensembl chr13:85,097,899...85,100,093 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Ethylmaleimide results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Gad1 glutamate decarboxylase 1 decreases activity ISO Ethylmaleimide results in decreased activity of GAD1 protein CTD PMID:15836621 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 decreases activity ISO Ethylmaleimide results in decreased activity of GAD2 protein CTD PMID:15836621 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Hoxb13 homeo box B13 increases response to substance ISO HOXB13 protein results in increased susceptibility to Ethylmaleimide CTD PMID:24213000 NCBI chr10:81,160,498...81,162,777
Ensembl chr10:81,160,498...81,162,777 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions ISO Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein] CTD PMID:22796344 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Ltbr lymphotoxin beta receptor multiple interactions ISO Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] CTD PMID:37193757 NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [APEX1 protein inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]] CTD PMID:23370007 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mt3 metallothionein 3 increases alkylation ISO Ethylmaleimide results in increased alkylation of MT3 protein CTD PMID:12383939 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158 		JBrowse link
G Osm oncostatin M multiple interactions ISO Ethylmaleimide promotes the reaction [OSM protein binds to LTBR protein] CTD PMID:37193757 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313 		JBrowse link
G Pah phenylalanine hydroxylase multiple interactions ISO Ethylmaleimide results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein] CTD PMID:19367645 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130 		JBrowse link
G Senp1 SUMO specific peptidase 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein] CTD PMID:26060329 NCBI chr 7:129,163,173...129,226,766
Ensembl chr 7:129,165,774...129,221,598 		JBrowse link
G Senp6 SUMO specific peptidase 6 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr 8:80,988,675...81,071,606
Ensembl chr 8:80,989,052...81,067,170 		JBrowse link
G Slc12a5 solute carrier family 12 member 5 increases activity
multiple interactions		 ISO Ethylmaleimide results in increased activity of SLC12A5 protein
Ethylmaleimide inhibits the reaction [SLC12A5 protein results in increased import of Thallium]		 CTD PMID:20086212 NCBI chr 3:153,696,517...153,735,801
Ensembl chr 3:153,696,517...153,735,765 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO Ethylmaleimide inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO Ethylmaleimide inhibits the reaction [CD 437 results in increased cleavage of SP1 protein] CTD PMID:9343396 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sumo2 small ubiquitin-like modifier 2 multiple interactions ISO Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP1 protein]; Ethylmaleimide inhibits the reaction [SUMO2 protein binds to SENP6 protein] CTD PMID:26060329 NCBI chr10:100,771,941...100,784,503
Ensembl chr10:100,686,797...100,784,513 		JBrowse link
G Tf transferrin decreases uptake ISO Ethylmaleimide results in decreased uptake of TF protein CTD PMID:10865941 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Ethylmaleimide inhibits the reaction [Clozapine results in decreased expression of TH protein] CTD PMID:15983997 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Ethylmaleimide inhibits the reaction [TNF protein results in increased expression of SOD2 protein] CTD PMID:7476933 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 affects binding EXP Ethylmaleimide binds to VDAC1 protein CTD PMID:20192921 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        antimicrobial agent 18141
          antiviral agent 11069
            anticoronaviral agent 9658
              N-ethylmaleimide 34
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbonyl compound 18869
                                    dicarboxylic acids and O-substituted derivatives 11070
                                      dicarboxylic acid 11064
                                        C4-dicarboxylic acid 1322
                                          butenedioic acid 620
                                            maleic acid 586
                                              maleimides 167
                                                maleimide 85
                                                  N-ethylmaleimide 34
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