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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alendronic acid
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Accession:CHEBI:2567 term browser browse the term
Definition:A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Synonyms:exact_synonym: (4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid)
 related_synonym: (4-Amino-1-hydroxybutylidene)bisphosphonic acid;   Alendronate;   Formula=C4H13NO7P2;   InChI=1S/C4H13NO7P2/c5-3-1-2-4(6,13(7,8)9)14(10,11)12/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);   InChIKey=OGSPWJRAVKPPFI-UHFFFAOYSA-N;   SMILES=NCCCC(O)(P(O)(O)=O)P(O)(O)=O;   acide alendronique;   acido alendronico;   acidum alendronicum
 xref: Beilstein:2275403;   CAS:66376-36-1;   DrugBank:DB00630;   Drug_Central:112;   HMDB:HMDB0001915;   KEGG:C07752;   KEGG:D07119;   LINCS:LSM-5831
 xref_mesh: MESH:D019386
 xref: MetaCyc:ALENDRONATE;   PDBeChem:AHD;   PMID:12657258;   PMID:16626694;   PMID:19630066;   PMID:24676887;   PMID:25315260;   PMID:25442070;   PMID:25445446;   PMID:25461393;   PMID:25577217;   PMID:25592133;   PMID:25595570;   PMID:25603732;   PMID:25619515;   PMID:25636638;   PMID:25639838;   Patent:BE903519;   Patent:US4705651;   Reaxys:2275403;   Wikipedia:Alendronic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:50647



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alendronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP Alendronate inhibits the reaction [Streptozocin results in increased activity of ACHE protein] CTD PMID:30481507 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Alendronate inhibits the reaction [Dexamethasone results in increased activity of ACP5 protein]; Alendronate inhibits the reaction [modafinil results in increased expression of ACP5 mRNA] CTD PMID:27387537 PMID:29649498 NCBI chr 9:22,038,023...22,047,042
Ensembl chr 9:22,038,023...22,047,007
JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 affects expression ISO Alendronate affects the expression of ADCYAP1 mRNA CTD PMID:16079270 NCBI chr17:93,506,448...93,513,967
Ensembl chr17:93,506,445...93,513,965
JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney multiple interactions ISO Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]] CTD PMID:30291735 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
JBrowse link
G App amyloid beta precursor protein multiple interactions EXP Alendronate inhibits the reaction [Streptozocin results in increased expression of APP protein] CTD PMID:30481507 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide affects expression ISO Alendronate affects the expression of ATP1A1 mRNA CTD PMID:16079270 NCBI chr 3:101,483,535...101,512,023
Ensembl chr 3:101,483,535...101,512,000
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 multiple interactions EXP Alendronate inhibits the reaction [Streptozocin results in increased expression of BACE1 protein] CTD PMID:30481507 NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697
JBrowse link
G Bglap bone gamma carboxyglutamate protein multiple interactions ISO [Nebivolol co-treated with Alendronate] inhibits the reaction [Methylprednisolone results in decreased secretion of BGLAP protein] CTD PMID:30291735 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771
JBrowse link
G Casp9 caspase 9 multiple interactions ISO TNFSF11 inhibits the reaction [Alendronate results in increased expression of CASP9 protein] CTD PMID:19405951 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287
JBrowse link
G Cat catalase multiple interactions ISO
EXP
Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]]
Alendronate inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
CTD PMID:30291735 PMID:30481507 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Cd3g CD3 antigen, gamma polypeptide affects expression ISO Alendronate affects the expression of CD3G mRNA CTD PMID:16079270 NCBI chr 9:44,880,870...44,891,729
Ensembl chr 9:44,880,870...44,891,729
JBrowse link
G Cdh2 cadherin 2 affects expression ISO Alendronate affects the expression of CDH2 mRNA CTD PMID:16079270 NCBI chr18:16,721,934...16,942,303
Ensembl chr18:16,721,934...16,942,303
JBrowse link
G Cdh6 cadherin 6 affects expression ISO Alendronate affects the expression of CDH6 mRNA CTD PMID:16079270 NCBI chr15:13,028,785...13,176,493
Ensembl chr15:13,028,787...13,173,761
JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 affects expression ISO Alendronate affects the expression of CDK5RAP3 mRNA CTD PMID:16079270 NCBI chr11:96,798,251...96,807,359
Ensembl chr11:96,798,252...96,807,322
JBrowse link
G Col11a1 collagen, type XI, alpha 1 affects expression ISO Alendronate affects the expression of COL11A1 mRNA CTD PMID:16079270 NCBI chr 3:113,823,933...114,014,405
Ensembl chr 3:113,824,189...114,014,367
JBrowse link
G Col5a1 collagen, type V, alpha 1 affects expression ISO Alendronate affects the expression of COL5A1 mRNA CTD PMID:16079270 NCBI chr 2:27,776,393...27,929,522
Ensembl chr 2:27,776,437...27,929,526
JBrowse link
G Col5a2 collagen, type V, alpha 2 affects expression ISO Alendronate affects the expression of COL5A2 mRNA CTD PMID:16079270 NCBI chr 1:45,413,491...45,542,442
Ensembl chr 1:45,413,481...45,542,442
JBrowse link
G Cpe carboxypeptidase E affects expression ISO Alendronate affects the expression of CPE mRNA CTD PMID:16079270 NCBI chr 8:65,045,576...65,146,143
Ensembl chr 8:65,045,576...65,146,088
JBrowse link
G Crybb2 crystallin, beta B2 affects expression ISO Alendronate affects the expression of CRYBB2 mRNA CTD PMID:16079270 NCBI chr 5:113,206,124...113,217,983
Ensembl chr 5:113,206,124...113,217,983
JBrowse link
G Cyp2a22 cytochrome P450, family 2, subfamily a, polypeptide 22 affects expression ISO Alendronate affects the expression of CYP2A1 mRNA CTD PMID:16079270 NCBI chr 7:26,631,564...26,638,838
Ensembl chr 7:26,631,056...26,638,809
JBrowse link
G Dusp6 dual specificity phosphatase 6 affects expression ISO Alendronate affects the expression of DUSP6 mRNA CTD PMID:16079270 NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 affects expression ISO Alendronate affects the expression of EGLN3 mRNA CTD PMID:16079270 NCBI chr12:54,225,767...54,250,660
Ensembl chr12:54,225,767...54,250,646
JBrowse link
G Fdps farnesyl diphosphate synthetase decreases activity ISO Alendronate results in decreased activity of FDPS protein CTD PMID:11160603 NCBI chr 3:89,000,895...89,009,274
Ensembl chr 3:89,000,895...89,009,266
JBrowse link
G Fgf9 fibroblast growth factor 9 affects expression ISO Alendronate affects the expression of FGF9 mRNA CTD PMID:16079270 NCBI chr14:58,308,543...58,350,311
Ensembl chr14:58,308,004...58,350,177
JBrowse link
G Fkbp3 FK506 binding protein 3 affects expression ISO Alendronate affects the expression of FKBP3 mRNA CTD PMID:16079270 NCBI chr12:65,109,206...65,120,712
Ensembl chr12:65,109,198...65,120,781
JBrowse link
G Gabrg1 gamma-aminobutyric acid type A receptor subunit gamma 1 affects expression ISO Alendronate affects the expression of GABRG1 mRNA CTD PMID:16079270 NCBI chr 5:70,906,512...70,999,960
Ensembl chr 5:70,908,390...70,999,960
JBrowse link
G Ghrh growth hormone releasing hormone affects expression ISO Alendronate affects the expression of GHRH mRNA CTD PMID:16079270 NCBI chr 2:157,171,416...157,190,645
Ensembl chr 2:157,171,417...157,189,426
JBrowse link
G Ghrhr growth hormone releasing hormone receptor affects expression ISO Alendronate affects the expression of GHRHR mRNA CTD PMID:16079270 NCBI chr 6:55,353,204...55,365,515
Ensembl chr 6:55,353,280...55,365,515
JBrowse link
G Gnb1 guanine nucleotide binding protein (G protein), beta 1 affects expression ISO Alendronate affects the expression of GNB1 mRNA CTD PMID:16079270 NCBI chr 4:155,575,514...155,643,726
Ensembl chr 4:155,575,818...155,643,726
JBrowse link
G Hal histidine ammonia lyase affects expression ISO Alendronate affects the expression of HAL mRNA CTD PMID:16079270 NCBI chr10:93,324,630...93,352,623
Ensembl chr10:93,324,630...93,355,166
JBrowse link
G Hmgb1 high mobility group box 1 affects expression ISO Alendronate affects the expression of HMGB1 mRNA CTD PMID:16079270 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299
JBrowse link
G Hoxa1 homeobox A1 affects expression ISO Alendronate affects the expression of HOXA1 mRNA CTD PMID:16079270 NCBI chr 6:52,132,573...52,135,299
Ensembl chr 6:52,132,570...52,135,297
JBrowse link
G Hras Harvey rat sarcoma virus oncogene decreases prenylation EXP Alendronate results in decreased prenylation of HRAS protein CTD PMID:9556058 NCBI chr 7:140,770,839...140,773,938
Ensembl chr 7:140,769,018...140,773,918
JBrowse link
G Htr5a 5-hydroxytryptamine (serotonin) receptor 5A affects expression ISO Alendronate affects the expression of HTR5A mRNA CTD PMID:16079270 NCBI chr 5:28,046,836...28,059,403
Ensembl chr 5:28,047,147...28,060,086
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial affects expression ISO Alendronate affects the expression of IDH2 mRNA CTD PMID:16079270 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140
JBrowse link
G Il18 interleukin 18 multiple interactions EXP [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP
ISO
Alendronate results in increased expression of IL1B protein
[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein; [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein; Alendronate inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Alendronate promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Clodronic Acid inhibits the reaction [Alendronate results in increased expression of IL1B protein]; Farnesol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; geraniol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; geranylgeraniol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]; Menthol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]
Alendronate inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]
CTD PMID:17375077 PMID:20304105 PMID:20804833 PMID:21430599 PMID:30481507 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO Alendronate inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA] CTD PMID:17375077 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Alendronate inhibits the reaction [Streptozocin results in increased expression of IL6 protein] CTD PMID:30481507 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
JBrowse link
G Kcnh5 potassium voltage-gated channel, subfamily H (eag-related), member 5 affects expression ISO Alendronate affects the expression of KCNH5 mRNA CTD PMID:16079270 NCBI chr12:74,943,991...75,224,625
Ensembl chr12:74,943,994...75,224,106
JBrowse link
G Lox lysyl oxidase affects expression ISO Alendronate affects the expression of LOX mRNA CTD PMID:16079270 NCBI chr18:52,649,132...52,662,939
Ensembl chr18:52,649,139...52,662,939
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 affects expression ISO Alendronate affects the expression of MAPK14 mRNA CTD PMID:16079270 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
decreases secretion
affects expression
ISO Alendronate results in decreased expression of MMP2 mRNA
Alendronate results in decreased secretion of MMP2 protein
Alendronate affects the expression of MMP2 mRNA
CTD PMID:15049011 PMID:16079270 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048
JBrowse link
G Muc1 mucin 1, transmembrane affects expression ISO Alendronate affects the expression of MUC1 mRNA CTD PMID:16079270 NCBI chr 3:89,136,363...89,140,688
Ensembl chr 3:89,136,364...89,140,688
JBrowse link
G Myl9 myosin, light polypeptide 9, regulatory affects expression ISO Alendronate affects the expression of MYL9 mRNA CTD PMID:16079270 NCBI chr 2:156,617,373...156,623,578
Ensembl chr 2:156,617,340...156,623,578
JBrowse link
G Nectin1 nectin cell adhesion molecule 1 affects expression ISO Alendronate affects the expression of NECTIN1 mRNA CTD PMID:16079270 NCBI chr 9:43,655,251...43,718,758
Ensembl chr 9:43,655,281...43,743,955
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO Alendronate affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein] CTD PMID:17375077 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Or10al6 olfactory receptor family 10 subfamily AL member 6 affects expression ISO Alendronate affects the expression of OR10AL6 mRNA CTD PMID:16079270 NCBI chr17:38,079,533...38,083,511
Ensembl chr17:38,079,498...38,084,640
JBrowse link
G Pcolce procollagen C-endopeptidase enhancer protein affects expression ISO Alendronate affects the expression of PCOLCE mRNA CTD PMID:16079270 NCBI chr 5:137,603,369...137,609,666
Ensembl chr 5:137,603,365...137,612,046
JBrowse link
G Pex5 peroxisomal biogenesis factor 5 affects expression ISO Alendronate affects the expression of PEX5 mRNA CTD PMID:16079270 NCBI chr 6:124,373,774...124,392,878
Ensembl chr 6:124,373,775...124,392,026
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 affects expression ISO Alendronate affects the expression of PHLPP mRNA CTD PMID:16079270 NCBI chr 1:106,099,599...106,321,975
Ensembl chr 1:106,099,482...106,321,980
JBrowse link
G Pias3 protein inhibitor of activated STAT 3 affects expression ISO Alendronate affects the expression of PIAS3 mRNA CTD PMID:16079270 NCBI chr 3:96,603,679...96,613,386
Ensembl chr 3:96,603,700...96,613,386
JBrowse link
G Pigr polymeric immunoglobulin receptor affects expression ISO Alendronate affects the expression of PIGR mRNA CTD PMID:16079270 NCBI chr 1:130,754,421...130,779,986
Ensembl chr 1:130,754,421...130,779,986
JBrowse link
G Plpp1 phospholipid phosphatase 1 affects expression ISO Alendronate affects the expression of PLPP1 mRNA CTD PMID:16079270 NCBI chr13:112,937,311...113,004,428
Ensembl chr13:112,937,326...113,004,428
JBrowse link
G Pon1 paraoxonase 1 decreases activity
multiple interactions
ISO Alendronate results in decreased activity of PON1 protein
[Alendronate results in decreased activity of PON1 protein] which results in decreased metabolism of homocysteine thiolactone; [Alendronate results in decreased activity of PON1 protein] which results in decreased metabolism of Paraoxon; [Alendronate results in decreased activity of PON1 protein] which results in decreased metabolism of phenyl acetate
CTD PMID:27387541 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Psap prosaposin affects expression ISO Alendronate affects the expression of PSAP mRNA CTD PMID:16079270 NCBI chr10:60,113,436...60,138,379
Ensembl chr10:60,113,449...60,138,376
JBrowse link
G Psme1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) affects expression ISO Alendronate affects the expression of PSME1 mRNA CTD PMID:16079270 NCBI chr14:55,815,951...55,818,984
Ensembl chr14:55,815,580...55,818,986
JBrowse link
G Ptgfrn prostaglandin F2 receptor negative regulator affects expression ISO Alendronate affects the expression of PTGFRN mRNA CTD PMID:16079270 NCBI chr 3:100,947,546...101,018,061
Ensembl chr 3:100,947,548...101,017,594
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Alendronate affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein] CTD PMID:17375077 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
JBrowse link
G Rap1a RAS-related protein 1a decreases prenylation ISO Alendronate results in decreased prenylation of RAP1A protein CTD PMID:11595616 NCBI chr 3:105,634,576...105,708,740
Ensembl chr 3:105,634,583...105,708,652
JBrowse link
G Rara retinoic acid receptor, alpha affects expression ISO Alendronate affects the expression of RARA mRNA CTD PMID:16079270 NCBI chr11:98,818,626...98,865,768
Ensembl chr11:98,818,644...98,865,768
JBrowse link
G Runx2 runt related transcription factor 2 multiple interactions ISO Alendronate promotes the reaction [modafinil results in increased expression of RUNX2 mRNA] CTD PMID:29649498 NCBI chr17:44,806,873...45,125,518
Ensembl chr17:44,806,874...45,125,684
JBrowse link
G Scn4a sodium channel, voltage-gated, type IV, alpha affects expression ISO Alendronate affects the expression of SCN4A mRNA CTD PMID:16079270 NCBI chr11:106,208,374...106,256,385
Ensembl chr11:106,209,418...106,244,114
JBrowse link
G Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 affects expression ISO Alendronate affects the expression of SERPINE2 mRNA CTD PMID:16079270 NCBI chr 1:79,772,038...79,836,382
Ensembl chr 1:79,771,914...79,838,897
JBrowse link
G Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 affects expression ISO Alendronate affects the expression of SERPINH1 mRNA CTD PMID:16079270 NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446
JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 affects expression ISO Alendronate affects the expression of SLC18A2 mRNA CTD PMID:16079270 NCBI chr19:59,249,310...59,284,444
Ensembl chr19:59,249,328...59,284,444
JBrowse link
G Slc19a1 solute carrier family 19 (folate transporter), member 1 affects expression ISO Alendronate affects the expression of SLC19A1 mRNA CTD PMID:16079270 NCBI chr10:76,868,103...76,886,266
Ensembl chr10:76,868,075...76,896,836
JBrowse link
G Slc6a4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 affects expression ISO Alendronate affects the expression of SLC6A4 mRNA CTD PMID:16079270 NCBI chr11:76,889,423...76,923,169
Ensembl chr11:76,889,429...76,923,166
JBrowse link
G Slit1 slit guidance ligand 1 affects expression ISO Alendronate affects the expression of SLIT1 mRNA CTD PMID:16079270 NCBI chr19:41,586,263...41,735,714
Ensembl chr19:41,588,696...41,732,104
JBrowse link
G Snn stannin affects expression ISO Alendronate affects the expression of SNN mRNA CTD PMID:16079270 NCBI chr16:10,884,162...10,892,849
Ensembl chr16:10,878,809...10,892,849
JBrowse link
G Sparc secreted acidic cysteine rich glycoprotein affects expression ISO Alendronate affects the expression of SPARC mRNA CTD PMID:16079270 NCBI chr11:55,284,985...55,310,906
Ensembl chr11:55,285,326...55,314,009
JBrowse link
G Stk4 serine/threonine kinase 4 increases cleavage EXP Alendronate results in increased cleavage of STK4 protein CTD PMID:14502240 NCBI chr 2:163,916,033...163,997,444
Ensembl chr 2:163,912,242...163,997,444
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Alendronate co-treated with zoledronic acid] results in increased expression of TGFB1 protein CTD PMID:18504149 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 affects expression ISO Alendronate affects the expression of TIMP1 mRNA CTD PMID:16079270 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein; Alendronate inhibits the reaction [Streptozocin results in increased expression of TNF protein]; geraniol inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; geraniol promotes the reaction [lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]]; lonafarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]; manumycin inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein] CTD PMID:21430599 PMID:30481507 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) multiple interactions ISO Alendronate inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B mRNA]; Alendronate inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein] CTD PMID:27387537 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880
JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 multiple interactions ISO TNFSF11 inhibits the reaction [Alendronate results in increased expression of CASP9 protein]
Alendronate inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 mRNA]; Alendronate inhibits the reaction [Dexamethasone results in increased expression of TNFSF11 protein]; Alendronate inhibits the reaction [modafinil results in increased expression of TNFSF11 mRNA]
CTD PMID:19405951 PMID:27387537 PMID:29649498 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483
JBrowse link
G Tnni3 troponin I, cardiac 3 affects expression ISO Alendronate affects the expression of TNNI3 mRNA CTD PMID:16079270 NCBI chr 7:4,521,304...4,526,228
Ensembl chr 7:4,521,304...4,527,228
JBrowse link
G Vdr vitamin D (1,25-dihydroxyvitamin D3) receptor affects response to substance
multiple interactions
ISO VDR gene polymorphism affects the susceptibility to Alendronate
VDR gene polymorphism affects the susceptibility to [Alendronate co-treated with Estrogens, Conjugated (USP) co-treated with Medroxyprogesterone Acetate]; VDR gene polymorphism affects the susceptibility to [Alendronate co-treated with Raloxifene Hydrochloride]
CTD PMID:12608943 PMID:15739035 NCBI chr15:97,752,308...97,806,177
Ensembl chr15:97,752,306...97,808,511
JBrowse link

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  CHEBI ontology 22210
    role 22195
      application 21776
        pharmaceutical 21191
          drug 21191
            bone density conservation agent 6178
              alendronic acid 79
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  CHEBI ontology 22210
    subatomic particle 22202
      composite particle 22202
        hadron 22202
          baryon 22202
            nucleon 22202
              atomic nucleus 22202
                atom 22202
                  main group element atom 22136
                    main group molecular entity 22136
                      s-block molecular entity 21732
                        hydrogen molecular entity 21649
                          hydrides 20781
                            inorganic hydride 18692
                              pnictogen hydride 18672
                                nitrogen hydride 18539
                                  azane 18446
                                    ammonia 18445
                                      organic amino compound 18445
                                        primary amino compound 9439
                                          alendronic acid 79
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