Egln3 (egl-9 family hypoxia-inducible factor 3) - Rat Genome Database

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Gene: Egln3 (egl-9 family hypoxia-inducible factor 3) Mus musculus
Analyze
Symbol: Egln3
Name: egl-9 family hypoxia-inducible factor 3
RGD ID: 732653
MGI Page MGI
Description: Enables peptidyl-proline dioxygenase activity. Involved in regulation of cell population proliferation and regulation of neuron apoptotic process. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; musculoskeletal system; and somite. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN3 (egl-9 family hypoxia inducible factor 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 2610021G09Rik; AI505553; AI648162; egl nine homolog 3; Hif-p4h; Hif-p4h-3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; Phd; Phd3; prolyl hydroxylase domain-containing protein 3; prolyl hydroxylase EGLN3; SM-2; SM-20
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391254,225,767 - 54,250,660 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1254,225,767 - 54,250,646 (-)EnsemblGRCm39 Ensembl
GRCm381254,178,981 - 54,203,874 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1254,178,981 - 54,203,860 (-)EnsemblGRCm38mm10GRCm38
MGSCv371255,279,968 - 55,304,861 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361255,100,608 - 55,125,474 (-)NCBIMGSCv36mm8
Celera1255,491,368 - 55,516,127 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1222.9NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alendronic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
aluminium atom  (EXP)
aluminium(0)  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphotericin B  (ISO)
andrographolide  (ISO)
arotinoid acid  (ISO)
Azaspiracid  (ISO)
Bardoxolone methyl  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
cantharidin  (EXP)
carbon nanotube  (EXP)
CHIR 99021  (ISO)
choline  (EXP)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
diazinon  (ISO)
dieldrin  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (ISO)
dimethylselenide  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
fenthion  (EXP)
flutamide  (ISO)
folic acid  (EXP)
gentamycin  (ISO)
GW 4064  (EXP)
heparin  (ISO)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
iron atom  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
ivermectin  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
menadione  (EXP)
methamphetamine  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
okadaic acid  (ISO)
organoselenium compound  (ISO)
orphenadrine  (ISO)
ozone  (EXP)
paracetamol  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
phenylephrine  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
raloxifene  (ISO)
ranitidine  (ISO)
reactive oxygen species  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
succimer  (EXP)
sunitinib  (ISO)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
theophylline  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
Tungsten carbide  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
XAV939  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (ISO)
nucleus  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adrenal chromaffin cell morphology  (IAGP)
abnormal adrenal gland secretion  (IAGP)
abnormal adrenal medulla morphology  (IAGP)
abnormal autopod morphology  (IAGP)
abnormal axon morphology  (IAGP)
abnormal carotid body morphology  (IAGP)
abnormal definitive hematopoiesis  (IAGP)
abnormal heart left ventricle morphology  (IAGP)
abnormal innervation  (IAGP)
abnormal nervous system development  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal pupil morphology  (IAGP)
abnormal sinus arrhythmia  (IEA)
abnormal snout morphology  (IAGP)
abnormal splenic cell ratio  (IAGP)
abnormal superior cervical ganglion morphology  (IAGP)
cardiomyopathy  (IAGP)
decreased circulating adrenaline level  (IAGP)
decreased circulating noradrenaline level  (IAGP)
decreased litter size  (IAGP)
decreased mitochondrial number  (IAGP)
decreased neuron apoptosis  (IAGP)
decreased survivor rate  (IAGP)
decreased systemic arterial blood pressure  (IAGP)
decreased systemic arterial systolic blood pressure  (IAGP)
decreased ventricle muscle contractility  (IAGP)
enlarged liver  (IAGP)
enlarged spleen  (IAGP)
enlarged superior cervical ganglion  (IAGP)
extramedullary hematopoiesis  (IAGP)
increased angiogenesis  (IAGP)
increased heart weight  (IAGP)
increased hematocrit  (IAGP)
increased hemoglobin content  (IAGP)
myocardial fiber degeneration  (IAGP)
neonatal lethality  (IAGP)
no abnormal phenotype detected  (IAGP)
polycythemia  (IAGP)
premature death  (IAGP)
reddish skin  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Differential and reciprocal regulation between hypoxia-inducible factor-alpha subunits and their prolyl hydroxylases in pulmonary arteries of rat with hypoxia-induced hypertension. Chen YR, etal., Acta Biochim Biophys Sin (Shanghai). 2006 Jun;38(6):423-34.
2. Prospective study assessing hypoxia-related proteins as markers for the outcome of treatment with sunitinib in advanced clear-cell renal cell carcinoma. Garcia-Donas J, etal., Ann Oncol. 2013 Sep;24(9):2409-14. doi: 10.1093/annonc/mdt219. Epub 2013 Jun 20.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. HIF-1 and HIF-2 transcription factors--similar but not identical. Loboda A, etal., Mol Cells. 2010 May;29(5):435-42. Epub 2010 Apr 12.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. Mouse MP Annotation Import Pipeline RGD automated import pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. HIF-prolyl hydroxylases in the rat kidney: physiologic expression patterns and regulation in acute kidney injury. Schodel J, etal., Am J Pathol. 2009 May;174(5):1663-74. doi: 10.2353/ajpath.2009.080687. Epub 2009 Apr 6.
13. Autoantibody against hypoxia-inducible factor prolyl hydroxylase-3 is a potential serological marker for renal cell carcinoma. Tanaka T, etal., J Cancer Res Clin Oncol. 2011 May;137(5):789-94. doi: 10.1007/s00432-010-0940-6. Epub 2010 Jul 31.
14. HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation. Willam C, etal., J Mol Cell Cardiol. 2006 Jul;41(1):68-77.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10543731   PMID:11042159   PMID:11076861   PMID:11574160   PMID:12234095   PMID:12477932   PMID:14610273   PMID:15210114   PMID:15489334   PMID:16141072  
PMID:16141073   PMID:16966370   PMID:17044072   PMID:17344222   PMID:17646578   PMID:18040029   PMID:18056838   PMID:18176562   PMID:18332118   PMID:18334619   PMID:18347341   PMID:19338032  
PMID:19720742   PMID:19786027   PMID:20089853   PMID:20185832   PMID:20439489   PMID:20600011   PMID:20651146   PMID:20733101   PMID:20926767   PMID:21270129   PMID:21317538   PMID:21677750  
PMID:21873635   PMID:22014577   PMID:22262480   PMID:22342504   PMID:22464323   PMID:22611156   PMID:22615432   PMID:22786772   PMID:22797300   PMID:22905089   PMID:22955912   PMID:22967998  
PMID:23264599   PMID:23649506   PMID:23690557   PMID:23978105   PMID:24030251   PMID:24037093   PMID:24145445   PMID:24194600   PMID:24440788   PMID:24508125   PMID:24626957   PMID:24748541  
PMID:24828078   PMID:25088999   PMID:25385837   PMID:25420773   PMID:25446011   PMID:25633836   PMID:25846796   PMID:26044310   PMID:26054543   PMID:26075818   PMID:26124271   PMID:26416771  
PMID:26774962   PMID:26818499   PMID:26856890   PMID:26972007   PMID:26995088   PMID:27088801   PMID:27325674   PMID:27331863   PMID:27561929   PMID:27565342   PMID:27614241   PMID:27635760  
PMID:27683416   PMID:27795296   PMID:27981571   PMID:27997827   PMID:28054119   PMID:28262664   PMID:28418093   PMID:28495754   PMID:28538180   PMID:28716863   PMID:28847650   PMID:28939592  
PMID:29051216   PMID:29445148   PMID:30248340   PMID:30250231   PMID:31029587   PMID:31092600   PMID:31202927   PMID:31346526   PMID:31356139   PMID:31375625   PMID:31959916   PMID:32663458  
PMID:32814068   PMID:33023907   PMID:33298456   PMID:33464382   PMID:33665549   PMID:33749901   PMID:33819286   PMID:33951416   PMID:34058227   PMID:34161765   PMID:34264866   PMID:34571849  
PMID:34610308   PMID:34718519   PMID:35124697   PMID:35242281   PMID:35247391   PMID:36509284   PMID:37140003   PMID:37252972   PMID:37400498   PMID:37509073   PMID:37524711  


Genomics

Comparative Map Data
Egln3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391254,225,767 - 54,250,660 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1254,225,767 - 54,250,646 (-)EnsemblGRCm39 Ensembl
GRCm381254,178,981 - 54,203,874 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1254,178,981 - 54,203,860 (-)EnsemblGRCm38mm10GRCm38
MGSCv371255,279,968 - 55,304,861 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361255,100,608 - 55,125,474 (-)NCBIMGSCv36mm8
Celera1255,491,368 - 55,516,127 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1222.9NCBI
EGLN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381433,924,227 - 33,951,074 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1433,924,227 - 34,462,774 (-)EnsemblGRCh38hg38GRCh38
GRCh371434,393,433 - 34,420,280 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361433,463,172 - 33,490,035 (-)NCBINCBI36Build 36hg18NCBI36
Build 341433,463,172 - 33,490,037NCBI
Celera1414,258,646 - 14,285,539 (-)NCBICelera
Cytogenetic Map14q13.1NCBI
HuRef1414,510,074 - 14,536,960 (-)NCBIHuRef
CHM1_11434,391,710 - 34,418,579 (-)NCBICHM1_1
T2T-CHM13v2.01428,121,430 - 28,148,293 (-)NCBIT2T-CHM13v2.0
Egln3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8677,385,549 - 77,411,015 (-)NCBIGRCr8
mRatBN7.2671,650,297 - 71,675,766 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl671,650,297 - 71,675,766 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx672,071,359 - 72,096,960 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0672,378,007 - 72,403,609 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0671,817,527 - 71,843,127 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0675,050,329 - 75,075,795 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl675,050,329 - 75,075,795 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0684,592,894 - 84,618,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4674,451,038 - 74,476,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1674,454,165 - 74,479,632 (-)NCBI
Celera670,500,466 - 70,525,910 (-)NCBICelera
Cytogenetic Map6q23NCBI
Egln3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540926,939,933 - 26,967,156 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540926,939,933 - 26,967,156 (+)NCBIChiLan1.0ChiLan1.0
EGLN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21535,243,634 - 35,269,614 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11434,460,135 - 34,486,476 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01414,689,398 - 14,716,301 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11432,880,330 - 32,907,248 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1432,880,324 - 32,907,241 (-)Ensemblpanpan1.1panPan2
EGLN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1812,873,755 - 12,901,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl812,875,387 - 12,901,709 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha812,682,830 - 12,710,865 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0812,977,975 - 13,005,981 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl812,979,608 - 13,005,982 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1812,659,735 - 12,687,739 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0812,742,506 - 12,770,341 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0813,031,833 - 13,059,696 (-)NCBIUU_Cfam_GSD_1.0
Egln3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864044,734,378 - 44,761,610 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364948,238,858 - 8,267,606 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364948,240,272 - 8,267,487 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EGLN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl765,805,522 - 65,833,529 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1765,805,513 - 65,833,536 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2770,667,662 - 70,695,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Egln3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248382,819,631 - 2,847,827 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248382,819,719 - 2,848,094 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Egln3
963 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:622
Count of miRNA genes:378
Interacting mature miRNAs:460
Transcripts:ENSMUST00000039516
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
13524839Ppiq10_mprepulse inhibition QTL 10 (mouse)121304319554945798Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
1302172Skts5_mskin tumor susceptibility 5 (mouse)Not determined122214886656149016Mouse
1301989Hdlq18_mHDL QTL 18 (mouse)Not determined122916068563160884Mouse
1300636Gct2_mgranulosa cell tumorigenesis 2 (mouse)Not determined122916068563160884Mouse
4141843Moen3_mmodifier of engrailed QTL 3 (mouse)Not determined122980158463801733Mouse
14747008Mancz10_mmandible centroid size 10 (mouse)122986352263863522Mouse
10402492Dipa8_mdrug induced psychomotor activation 8 (mouse)Not determined123493387268934019Mouse
1300818Bbaa10_mB.burgdorferi-associated arthritis 10 (mouse)Not determined123509100465511019Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
12904004Opfaq11_mopen field activity QTL 11 (mouse)125315562457276756Mouse

Markers in Region
AI505553  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381254,179,020 - 54,179,105UniSTSGRCm38
MGSCv371255,280,007 - 55,280,092UniSTSGRCm37
Celera1255,491,407 - 55,491,492UniSTS
Cytogenetic Map12C1UniSTS
Whitehead/MRC_RH12546.68UniSTS
AI648162  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381254,179,936 - 54,180,033UniSTSGRCm38
MGSCv371255,280,923 - 55,281,020UniSTSGRCm37
Celera1255,492,314 - 55,492,411UniSTS
Cytogenetic Map12C1UniSTS
Whitehead/MRC_RH12554.13UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000039516   ⟹   ENSMUSP00000041874
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1254,225,767 - 54,250,646 (-)Ensembl
GRCm38.p6 Ensembl1254,178,981 - 54,203,860 (-)Ensembl
RefSeq Acc Id: NM_028133   ⟹   NP_082409
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391254,225,767 - 54,250,660 (-)NCBI
GRCm381254,178,981 - 54,203,874 (-)ENTREZGENE
MGSCv371255,279,968 - 55,304,861 (-)RGD
Celera1255,491,368 - 55,516,127 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036157168   ⟹   XP_036013061
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391254,225,767 - 54,250,648 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_082409   ⟸   NM_028133
- UniProtKB: A0A0R4J0H9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000041874   ⟸   ENSMUST00000039516
RefSeq Acc Id: XP_036013061   ⟸   XM_036157168
- Peptide Label: isoform X1
Protein Domains
Fe2OG dioxygenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91UZ4-F1-model_v2 AlphaFold Q91UZ4 1-239 view protein structure

Promoters
RGD ID:8678270
Promoter ID:EPDNEW_M17166
Type:initiation region
Name:Egln3_1
Description:Mus musculus egl-9 family hypoxia-inducible factor 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381254,203,801 - 54,203,861EPDNEW
RGD ID:6822873
Promoter ID:MM_KWN:11638
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_028133
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361255,304,459 - 55,304,959 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1932288 AgrOrtholog
Ensembl Genes ENSMUSG00000035105 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000039516 ENTREZGENE
  ENSMUST00000039516.4 UniProtKB/TrEMBL
Gene3D-CATH q2cbj1_9rhob like domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Oxoglu/Fe-dep_dioxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro_4_hyd_alph UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pro_4_hyd_alph_FE2OG_OXY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:112407 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1932288 ENTREZGENE
NCBI Gene 112407 ENTREZGENE
PANTHER EGL NINE HOMOLOG-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROLYL HYDROXYLASE EGLN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 2OG-FeII_Oxy_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Egln3 PhenoGen
PROSITE FE2OG_OXY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART P4Hc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J0H9 ENTREZGENE, UniProtKB/TrEMBL
  EGLN3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q3TCG8 UniProtKB/Swiss-Prot
  Q8C8M6 UniProtKB/Swiss-Prot
  Q8CCA8 UniProtKB/Swiss-Prot
  Q8R5C7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-06-10 Egln3  egl-9 family hypoxia-inducible factor 3    EGL nine homolog 3 (C. elegans)  Symbol and/or name change 5135510 APPROVED