Kcnh5 (potassium voltage-gated channel, subfamily H (eag-related), member 5) - Rat Genome Database

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Gene: Kcnh5 (potassium voltage-gated channel, subfamily H (eag-related), member 5) Mus musculus
Analyze
Symbol: Kcnh5
Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
RGD ID: 1621304
MGI Page MGI
Description: Predicted to enable transmembrane transporter binding activity and voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to act upstream of or within regulation of G2/M transition of mitotic cell cycle. Predicted to be located in cell surface. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in plasma membrane. Is expressed in several structures, including blood vessel; central nervous system; eye; genitourinary system; and thymus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human KCNH5 (potassium voltage-gated channel subfamily H member 5).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Eag2; ether-a-go-go potassium channel 2; potassium voltage-gated channel subfamily H member 5; voltage-gated potassium channel subunit Kv10.2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391274,943,991 - 75,224,625 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1274,943,994 - 75,224,106 (-)EnsemblGRCm39 Ensembl
GRCm381274,897,217 - 75,177,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1274,897,220 - 75,177,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv371275,998,204 - 76,278,319 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361275,816,060 - 76,096,172 (-)NCBIMGSCv36mm8
Celera1275,988,289 - 76,268,710 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1232.62NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16602821   PMID:17298852   PMID:19580749   PMID:21267068  
PMID:21677750   PMID:21873635   PMID:22345400   PMID:22855790   PMID:32325033  


Genomics

Comparative Map Data
Kcnh5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391274,943,991 - 75,224,625 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1274,943,994 - 75,224,106 (-)EnsemblGRCm39 Ensembl
GRCm381274,897,217 - 75,177,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1274,897,220 - 75,177,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv371275,998,204 - 76,278,319 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361275,816,060 - 76,096,172 (-)NCBIMGSCv36mm8
Celera1275,988,289 - 76,268,710 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1232.62NCBI
KCNH5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381462,699,464 - 63,045,458 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1462,699,464 - 63,102,037 (-)EnsemblGRCh38hg38GRCh38
GRCh371463,166,182 - 63,512,176 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361462,243,698 - 62,638,337 (-)NCBINCBI36Build 36hg18NCBI36
Build 341462,248,710 - 62,638,337NCBI
Celera1443,224,258 - 43,619,167 (-)NCBICelera
Cytogenetic Map14q23.2NCBI
HuRef1443,338,760 - 43,678,420 (-)NCBIHuRef
CHM1_11463,112,492 - 63,451,134 (-)NCBICHM1_1
T2T-CHM13v2.01456,906,444 - 57,253,090 (-)NCBIT2T-CHM13v2.0
Kcnh5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8699,350,947 - 99,643,856 (-)NCBIGRCr8
mRatBN7.2693,615,174 - 93,908,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl693,624,529 - 93,908,107 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx694,022,247 - 94,304,742 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0694,320,761 - 94,603,257 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0693,749,598 - 94,032,105 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0697,872,831 - 98,157,087 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl697,872,831 - 98,157,087 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06107,294,666 - 107,578,241 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4697,484,188 - 97,772,082 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1697,487,643 - 97,775,538 (-)NCBI
Celera692,059,360 - 92,339,391 (-)NCBICelera
Cytogenetic Map6q24NCBI
Kcnh5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554666,704,364 - 7,040,734 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554666,704,431 - 7,042,727 (+)NCBIChiLan1.0ChiLan1.0
KCNH5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21563,827,105 - 64,163,258 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11463,043,619 - 63,379,775 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01443,297,114 - 43,633,275 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11461,560,591 - 61,889,137 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1461,560,600 - 61,889,137 (-)Ensemblpanpan1.1panPan2
KCNH5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1837,429,677 - 37,710,409 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl837,434,922 - 37,710,330 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha837,191,479 - 37,467,676 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0837,663,234 - 37,937,001 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl837,666,227 - 37,936,864 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1837,271,557 - 37,554,004 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0837,357,200 - 37,633,582 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0837,713,171 - 37,986,803 (-)NCBIUU_Cfam_GSD_1.0
Kcnh5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864067,223,309 - 67,517,223 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364956,685,238 - 6,967,591 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364956,685,220 - 6,967,921 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNH5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1194,966,334 - 195,259,068 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11194,965,696 - 195,264,046 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNH5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12439,856,837 - 40,206,607 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605328,091,424 - 28,430,148 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnh5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473437,990,890 - 38,381,306 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473437,990,840 - 38,387,580 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnh5
9252 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:71
Interacting mature miRNAs:77
Transcripts:ENSMUST00000042299
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
1558978Cplaq10_mcircadian period of locomotor activity 10 (mouse)Not determined121534102679040364Mouse
1301574Lmblgq5_mlimb length QTL 5 (mouse)Not determined121759644780956883Mouse
4142002Tbqt3_mtibia bone quality traits 3 (mouse)Not determined1235285496109936243Mouse
1357479Splwt1_mspleen weight 1 (mouse)Not determined124169317590887526Mouse
1357757Lnopy2_mlens opacity 2 (mouse)Not determined125284662686846796Mouse
1357749Vtbt13_mvertebral trabecular bone trait 13 (mouse)Not determined125313200287132145Mouse
12832727Ahrq1_mairway hyperresponsiveness QTL 1 (mouse)125469591082665939Mouse
13504832Bacszq2_mbaculum size QTL 2 (mouse)125694579875345787Mouse
27226728Tibl20_mtibia length 20, 16 week (mouse)125914678693866774Mouse
27226776Tibl6_mtibia length 6, 5 week (mouse)126064678692666774Mouse
10043948Pbft6_mpercent body fat 6 (mouse)Not determined126120542795205427Mouse
1301476Pbwg12_mpostnatal body weight growth 12 (mouse)Not determined126204016496040364Mouse
27226797Scvln19_msacral vertebrae length 2, 16 week (mouse)126214678699466259Mouse
10043895Bw20_mbody weight QTL 20 (mouse)Not determined126230825296308252Mouse
1301046Par3_mpulmonary adenoma resistance 3 (mouse)Not determined126395670897956883Mouse
1301337Cdcs8_mcytokine deficiency colitis susceptibility 8 (mouse)Not determined126468908398689229Mouse
1300633Cdcs7_mcytokine deficiency colitis susceptibility 7 (mouse)Not determined126468908398689229Mouse
14746976Manh73_mmandible shape 73 (mouse)126585713199857131Mouse
27226771Tibl14_mtibia length 14, 10 week (mouse)126834677498766259Mouse
27226793Feml10_mfemur length 10, 5 week (mouse)1268346774113363620Mouse
4141738Tgq23_mtriglyceride QTL 23 (mouse)Not determined72112877106112877Mouse
1301926Adip6_madiposity 6 (mouse)Not determined1273887422107887526Mouse
1301689Skull18_mskull morphology 18 (mouse)Not determined1273887422107887526Mouse

Markers in Region
31.MMHAP7FLC4.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381274,946,549 - 74,946,699UniSTSGRCm38
MGSCv371276,047,536 - 76,047,686UniSTSGRCm37
Celera1276,037,230 - 76,037,380UniSTS
Cytogenetic Map12C3UniSTS
Whitehead/MRC_RH12690.87UniSTS
Kcnh5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12C3UniSTS
cM Map12 UniSTS
D14S1251  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381274,897,268 - 74,897,416UniSTSGRCm38
MGSCv371275,998,255 - 75,998,403UniSTSGRCm37
Celera1275,988,340 - 75,988,488UniSTS
Cytogenetic Map12C3UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000042299   ⟹   ENSMUSP00000046864
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1274,943,994 - 75,224,106 (-)Ensembl
GRCm38.p6 Ensembl1274,897,220 - 75,177,332 (-)Ensembl
RefSeq Acc Id: NM_172805   ⟹   NP_766393
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391274,943,991 - 75,224,106 (-)NCBI
GRCm381274,897,217 - 75,177,332 (-)ENTREZGENE
MGSCv371275,998,204 - 76,278,319 (-)RGD
Celera1275,988,289 - 76,268,710 (-)RGD
cM Map12 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036157403   ⟹   XP_036013296
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391275,040,503 - 75,224,625 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_766393 (Get FASTA)   NCBI Sequence Viewer  
  XP_036013296 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH66138 (Get FASTA)   NCBI Sequence Viewer  
  AAL09442 (Get FASTA)   NCBI Sequence Viewer  
  BAC27869 (Get FASTA)   NCBI Sequence Viewer  
  EDL36491 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000046864
  ENSMUSP00000046864.3
GenBank Protein Q920E3 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_766393   ⟸   NM_172805
- UniProtKB: E9QPM0 (UniProtKB/Swiss-Prot),   Q8C035 (UniProtKB/Swiss-Prot),   Q920E3 (UniProtKB/Swiss-Prot),   Q6NZH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000046864   ⟸   ENSMUST00000042299
RefSeq Acc Id: XP_036013296   ⟸   XM_036157403
- Peptide Label: isoform X1
Protein Domains
Cyclic nucleotide-binding   PAC   PAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q920E3-F1-model_v2 AlphaFold Q920E3 1-988 view protein structure

Promoters
RGD ID:8678538
Promoter ID:EPDNEW_M17300
Type:multiple initiation site
Name:Kcnh5_1
Description:Mus musculus potassium voltage-gated channel, subfamily H (eag-related),member 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381275,177,350 - 75,177,410EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3584508 AgrOrtholog
Ensembl Genes ENSMUSG00000034402 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000042299 ENTREZGENE
  ENSMUST00000042299.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.1200.260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_EAG/ELK/ERG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-assoc_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:238271 UniProtKB/Swiss-Prot
MGD MGI:3584508 ENTREZGENE
NCBI Gene 238271 ENTREZGENE
PANTHER PTHR10217:SF533 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAS_9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnh5 PhenoGen
PRINTS EAGCHANLFMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EAGCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9QPM0 ENTREZGENE
  KCNH5_MOUSE UniProtKB/Swiss-Prot
  Q6NZH0 ENTREZGENE, UniProtKB/TrEMBL
  Q8C035 ENTREZGENE
  Q920E3 ENTREZGENE
UniProt Secondary E9QPM0 UniProtKB/Swiss-Prot
  Q8C035 UniProtKB/Swiss-Prot