Other T2D candidate genes

Candidate genes have been identified in linkage analyses and GWAS studies as potential susceptibility loci for T2D; some of these genes may have a role to play in the functioning of beta-cell insulin gene expression and function [see for instance the reference PMIDs 19000735 or 22540253. The genes are listed with aliases in parentheses, full names and links to gene report pages:

Capn10 (Niddm1) – calpain 10
Pparg (Nr1c3, Ppargamma, Pparg1, Pparg2) – peroxisome proliferator-activated receptor gamma
Tcf7l2 (Tcf4, Tcf-4) – transcription factor 7 like 2
Cdkal1 – CDK5 regulatory subunit associated protein 1-like 1
Cdkn2a (Ink4, Cdkn2, Ink4a) – cyclin-dependent kinase inhibitor 2A
Cdkn2b (Ink4b) – cyclin-dependent kinase inhibitor 2B
Hhex (Hmph, Hex, Prhx) – hematopoietically expressed homeobox
Ide – insulin degrading enzyme
Slc30a8 (Znt-8, Znt8) – solute carrier family 30 member 8
Igf2bp2 (p62, Imp2, Imp-2) – insulin-like growth factor 2 mRNA binding protein 2
Wfs1 (Wfrs, Wfs, Wolframin) – wolframin ER transmembrane glycoprotein
Hnf1b (Tcf2) – HNF1 homeobox B
Fto (fat mass and obesity associated) – FTO, alpha-ketoglutarate dependent dioxygenase
Mc4r – melanocortin 4 receptor
Notch2 (Notch homolog 2 (Drosophila)) – Notch 2
Adamts9 – ADAM metallopeptidase with thrombospondin type 1 motif, 9
Thada – THADA, armadillo repeat containing
Tspan8 (CO-29, Tm4sf3) – tetraspanin 8
Lgr5 (Gpr49) – leucine rich repeat containing G protein coupled receptor 5
Cdc123 (D123) – cell division cycle 123
CAMK1D (CaMKD, CKLiK, CaM-K1) – calcium/calmodulin dependent protein kinase ID
Jazf1 – JAZF zinc finger 1