Hhex (hematopoietically expressed homeobox) - Rat Genome Database

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Gene: Hhex (hematopoietically expressed homeobox) Rattus norvegicus
Analyze
Symbol: Hhex
Name: hematopoietically expressed homeobox
RGD ID: 619932
Description: Enables sequence-specific DNA binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of transcription by RNA polymerase II; and negative regulation of vascular endothelial growth factor receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of protein-DNA complex. Orthologous to human HHEX (hematopoietically expressed homeobox); PARTICIPATES IN maturity-onset diabetes of the young pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hematopoietically-expressed homeobox protein HHEX; Hex
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,602,945 - 244,608,532 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1244,602,825 - 244,608,604 (+)EnsemblGRCr8
mRatBN7.21235,190,455 - 235,196,042 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,190,455 - 235,196,042 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1243,576,013 - 243,581,585 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01250,507,808 - 250,513,395 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,345,997 - 243,351,584 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01256,101,994 - 256,107,581 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1256,101,903 - 256,107,649 (+)Ensemblrn6Rnor6.0
Rnor_5.01263,583,988 - 263,589,575 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41241,736,542 - 241,742,129 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1232,281,249 - 232,286,836 (+)NCBICelera
RGSC_v3.11241,926,133 - 241,931,721 (+)NCBI
Cytogenetic Map1q53NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
acetaldehyde  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
azathioprine  (ISO)
belinostat  (ISO)
benzene  (EXP)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diazinon  (ISO)
diclofenac  (ISO)
dimethylarsinic acid  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fipronil  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
furan  (EXP)
GW 4064  (ISO)
inositol  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
metformin  (EXP)
methotrexate  (ISO)
methylarsonic acid  (ISO)
methylmercury(1+)  (EXP)
mitomycin C  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrates  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorobutanesulfonic acid  (EXP)
perfluorobutyric acid  (EXP)
perfluorododecanoic acid  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorohexanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
perfluoroundecanoic acid  (EXP)
phenformin  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
quercetin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
testosterone  (ISO)
tetracycline  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
anterior/posterior pattern specification  (IEA,ISO)
B cell differentiation  (ISO)
cell differentiation  (IBA,IDA)
common bile duct development  (ISO)
DNA conformation change  (ISO)
embryonic heart tube development  (ISO)
embryonic organ development  (ISO)
endoderm development  (ISO)
forebrain development  (ISO)
forebrain morphogenesis  (ISO)
gallbladder development  (ISO)
hemopoiesis  (ISO,TAS)
hepatic duct development  (ISO)
hepatoblast differentiation  (ISO)
hepatocyte differentiation  (ISO)
in utero embryonic development  (ISO)
interkinetic nuclear migration  (ISO)
liver development  (ISO)
morphogenesis of an epithelium  (ISO)
multicellular organism growth  (ISO)
myeloid leukocyte differentiation  (ISO)
negative regulation of angiogenesis  (IDA,IEA,ISO)
negative regulation of cytoplasmic translational initiation  (ISO)
negative regulation of DNA-templated transcription  (IDA,IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
negative regulation of vascular endothelial growth factor receptor signaling pathway  (IDA,IEA,ISO)
Notch signaling pathway  (ISO)
pancreas development  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of Wnt signaling pathway  (IEA,ISO)
primary lung bud formation  (ISO)
primitive streak formation  (ISO)
protein localization to nucleus  (ISO)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of leukocyte proliferation  (ISO)
regulation of mRNA export from nucleus  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO)
response to peptide hormone  (IEP)
signal transduction  (ISO)
thyroid gland development  (ISO)
tissue morphogenesis  (ISO)
vasculogenesis  (ISO)

Cellular Component
cytoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
protein-DNA complex  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Getting your head around Hex and Hesx1: forebrain formation in mouse. Martinez-Barbera JP and Beddington RS, Int J Dev Biol 2001;45(1):327-36.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling. Minami T, etal., J Biol Chem. 2004 May 14;279(20):20626-35. Epub 2004 Mar 10.
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Expression and function of the homeodomain-containing protein Hex in thyroid cells. Pellizzari L, etal., Nucleic Acids Res. 2000 Jul 1;28(13):2503-11.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Homeobox protein Hex induces SMemb/nonmuscle myosin heavy chain-B gene expression through the cAMP-responsive element. Sekiguchi K, etal., Circ Res. 2001 Jan 19;88(1):52-8.
11. cDNA cloning and expression of rat homeobox gene, Hex, and functional characterization of the protein. Tanaka T, etal., Biochem J 1999 Apr 1;339 ( Pt 1):111-7.
Additional References at PubMed
PMID:10804173   PMID:10804184   PMID:11027604   PMID:11044484   PMID:12477932   PMID:12522149   PMID:12554669   PMID:12588764   PMID:12655000   PMID:12791650   PMID:12826010   PMID:14736744  
PMID:15187083   PMID:15459110   PMID:15581879   PMID:15728128   PMID:16364283   PMID:16540119   PMID:16582099   PMID:16764824   PMID:16854221   PMID:16936074   PMID:17580084   PMID:18713067  
PMID:18755198   PMID:21445260   PMID:25446530   PMID:26306672   PMID:28927755  


Genomics

Comparative Map Data
Hhex
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,602,945 - 244,608,532 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1244,602,825 - 244,608,604 (+)EnsemblGRCr8
mRatBN7.21235,190,455 - 235,196,042 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,190,455 - 235,196,042 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1243,576,013 - 243,581,585 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01250,507,808 - 250,513,395 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,345,997 - 243,351,584 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01256,101,994 - 256,107,581 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1256,101,903 - 256,107,649 (+)Ensemblrn6Rnor6.0
Rnor_5.01263,583,988 - 263,589,575 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41241,736,542 - 241,742,129 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1232,281,249 - 232,286,836 (+)NCBICelera
RGSC_v3.11241,926,133 - 241,931,721 (+)NCBI
Cytogenetic Map1q53NCBI
HHEX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381092,689,955 - 92,695,647 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1092,689,903 - 92,695,647 (+)Ensemblhg38GRCh38
GRCh371094,449,712 - 94,455,404 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,439,661 - 94,445,388 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341094,439,691 - 94,445,383NCBI
Celera1088,191,085 - 88,196,812 (+)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1088,076,253 - 88,081,980 (+)NCBIHuRef
CHM1_11094,732,137 - 94,737,863 (+)NCBICHM1_1
T2T-CHM13v2.01093,569,602 - 93,575,294 (+)NCBIT2T-CHM13v2.0
Hhex
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,423,289 - 37,429,179 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,423,258 - 37,429,179 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381937,434,841 - 37,440,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,434,810 - 37,440,731 (+)Ensemblmm10GRCm38
MGSCv371937,509,331 - 37,515,221 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361937,499,985 - 37,505,875 (+)NCBIMGSCv36mm8
Celera1938,221,629 - 38,227,525 (+)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.28NCBI
Hhex
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955425735,378 - 742,775 (-)Ensembl
ChiLan1.0NW_004955425737,506 - 742,775 (-)NCBIChiLan1.0ChiLan1.0
HHEX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28104,725,043 - 104,730,830 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110104,730,394 - 104,736,144 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01089,433,402 - 89,439,137 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11092,947,373 - 92,952,992 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1092,947,373 - 92,952,992 (+)EnsemblpanPan2panpan1.1
HHEX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1287,057,379 - 7,063,326 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,057,283 - 7,063,330 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha287,233,996 - 7,239,896 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0287,317,251 - 7,323,151 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,317,203 - 7,323,145 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1287,037,744 - 7,043,641 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0287,072,416 - 7,078,310 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,236,847 - 7,242,744 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Hhex
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721340,504,266 - 40,511,263 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366012,136,873 - 2,143,857 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366012,137,490 - 2,143,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HHEX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14104,194,343 - 104,200,219 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114104,194,424 - 104,199,684 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214113,794,343 - 113,799,603 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HHEX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1985,957,684 - 85,963,414 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl985,957,779 - 85,963,404 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604846,697,779 - 46,703,530 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hhex
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247373,897,871 - 3,904,083 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247373,897,907 - 3,903,828 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Hhex
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1236,340,405 - 36,346,025 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Hhex
18 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:273
Count of miRNA genes:186
Interacting mature miRNAs:207
Transcripts:ENSRNOT00000022384
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
AA957911  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,195,228 - 235,195,412 (+)MAPPERmRatBN7.2
Rnor_6.01256,106,768 - 256,106,951NCBIRnor6.0
Rnor_5.01263,588,762 - 263,588,945UniSTSRnor5.0
RGSC_v3.41241,741,316 - 241,741,499UniSTSRGSC3.4
Celera1232,286,023 - 232,286,206UniSTS
Cytogenetic Map1q53UniSTS
D6S1641  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21235,195,627 - 235,196,465 (+)MAPPERmRatBN7.2
Rnor_6.01256,107,167 - 256,108,004NCBIRnor6.0
Rnor_5.01263,589,161 - 263,589,998UniSTSRnor5.0
RGSC_v3.41241,741,715 - 241,742,552UniSTSRGSC3.4
Celera1232,286,422 - 232,287,259UniSTS
Cytogenetic Map1q53UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 92 59 6 355 192 11 136 80 92 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000022384   ⟹   ENSRNOP00000022384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1244,602,825 - 244,608,604 (+)Ensembl
mRatBN7.2 Ensembl1235,190,455 - 235,196,042 (+)Ensembl
Rnor_6.0 Ensembl1256,101,903 - 256,107,649 (+)Ensembl
RefSeq Acc Id: NM_024385   ⟹   NP_077361
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81244,602,945 - 244,608,532 (+)NCBI
mRatBN7.21235,190,455 - 235,196,042 (+)NCBI
Rnor_6.01256,101,994 - 256,107,581 (+)NCBI
Rnor_5.01263,583,988 - 263,589,575 (+)NCBI
RGSC_v3.41241,736,542 - 241,742,129 (+)RGD
Celera1232,281,249 - 232,286,836 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077361 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88135 (Get FASTA)   NCBI Sequence Viewer  
  BAA78692 (Get FASTA)   NCBI Sequence Viewer  
  EDM13199 (Get FASTA)   NCBI Sequence Viewer  
  EDM13200 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022384
  ENSRNOP00000022384.6
RefSeq Acc Id: NP_077361   ⟸   NM_024385
- UniProtKB: Q9WV22 (UniProtKB/TrEMBL),   F7F7Q9 (UniProtKB/TrEMBL),   A0A9K3Y8F2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022384   ⟸   ENSRNOT00000022384
Protein Domains
Homeobox

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7F7Q9-F1-model_v2 AlphaFold F7F7Q9 1-246 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690877
Promoter ID:EPDNEW_R1402
Type:multiple initiation site
Name:Hhex_1
Description:hematopoietically expressed homeobox
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01256,101,976 - 256,102,036EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619932 AgrOrtholog
BioCyc Gene G2FUF-55804 BioCyc
Ensembl Genes ENSRNOG00000016595 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022384 ENTREZGENE
  ENSRNOT00000022384.7 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7366155 IMAGE-MGC_LOAD
InterPro Homeobox UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_DNA-bind_prot UniProtKB/TrEMBL
  Homeobox_region UniProtKB/TrEMBL
  Homeobox_TF UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
KEGG Report rno:79237 UniProtKB/TrEMBL
MGC_CLONE MGC:108673 IMAGE-MGC_LOAD
NCBI Gene 79237 ENTREZGENE
PANTHER HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX UniProtKB/TrEMBL
  HOMEO BOX HB9 LIKE A-RELATED UniProtKB/TrEMBL
  HOMEOBOX PROTEIN HHEX UniProtKB/TrEMBL
  VENT HOMEOBOX UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
PharmGKB HHEX RGD
PhenoGen Hhex PhenoGen
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016595 RatGTEx
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP Homeodomain_like UniProtKB/TrEMBL
UniProt A0A9K3Y8F2 ENTREZGENE, UniProtKB/TrEMBL
  A6I169_RAT UniProtKB/TrEMBL
  F7F7Q9 ENTREZGENE
  Q9WV22 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7F7Q9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Hhex  hematopoietically expressed homeobox      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Hhex  hematopoietically expressed homeobox      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expression is induced by retinoic acid 625370