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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619932
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hhex
Name: hematopoietically expressed homeobox
Acc ID: CHEBI:16755
Term: chenodeoxycholic acid
Definition: A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
Chemical ID: MESH:D002635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hhexincreases expressionISOHHEX (Homo sapiens)6480464CTDChenodeoxycholic Acid results in increased expression of HHEX mRNAPMID:19072826
Hhexincreases expressionISOHhex (Mus musculus)6480464CTDChenodeoxycholic Acid results in increased expression of HHEX mRNA; Chenodeoxycholic Acid results in increased expression of HHEX proteinPMID:19072826
Hhexmultiple interactionsISOHHEX (Homo sapiens)6480464CTDChenodeoxycholic Acid promotes the reaction [NR1H4 binds to HHEX intron]; NR1H4 affects the reaction [Chenodeoxycholic Acid results in increased expression of HHEX mRNA]PMID:19072826
Hhexmultiple interactionsISOHhex (Mus musculus)6480464CTDNR1H4 mutant form inhibits the reaction [Chenodeoxycholic Acid results in increased expression of HHEX mRNA]; NR1H4 mutant form inhibits the reaction [Chenodeoxycholic Acid results in increased expression of HHEX protein]PMID:19072826
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