HHEX (hematopoietically expressed homeobox) - Rat Genome Database

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Gene: HHEX (hematopoietically expressed homeobox) Canis lupus familiaris
Analyze
Symbol: HHEX
Name: hematopoietically expressed homeobox
RGD ID: 12183555
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor activity (ortholog); HMG box domain binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); B cell differentiation (ortholog); ASSOCIATED WITH Breast Neoplasms (ortholog); genetic disease (ortholog); polycystic liver disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); protein-DNA complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: hematopoietically-expressed homeobox protein HHEX
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1287,057,379 - 7,063,326 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,057,283 - 7,063,330 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,233,996 - 7,239,896 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0287,317,251 - 7,323,151 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,317,203 - 7,323,145 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1287,037,744 - 7,043,641 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0287,072,416 - 7,078,310 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,236,847 - 7,242,744 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
anterior/posterior pattern specification  (ISO)
B cell differentiation  (ISO)
cell differentiation  (IEA,ISO)
common bile duct development  (ISO)
DNA conformation change  (IEA)
embryonic heart tube development  (ISO)
embryonic organ development  (ISO)
endoderm development  (ISO)
forebrain development  (ISO)
forebrain morphogenesis  (ISO)
gallbladder development  (ISO)
hemopoiesis  (ISO)
hepatic duct development  (ISO)
hepatoblast differentiation  (ISO)
hepatocyte differentiation  (ISO)
in utero embryonic development  (ISO)
interkinetic nuclear migration  (ISO)
liver development  (ISO)
morphogenesis of an epithelium  (ISO)
mRNA export from nucleus  (IEA)
multicellular organism growth  (ISO)
myeloid leukocyte differentiation  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of vascular endothelial growth factor receptor signaling pathway  (ISO)
Notch signaling pathway  (ISO)
pancreas development  (ISO)
poly(A)+ mRNA export from nucleus  (IEA)
positive regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of Wnt signaling pathway  (ISO)
primary lung bud formation  (ISO)
primitive streak formation  (ISO)
protein localization to nucleus  (IEA)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of leukocyte proliferation  (IEA)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to peptide hormone  (ISO)
signal transduction  (ISO)
thyroid gland development  (ISO)
tissue morphogenesis  (ISO)
vasculogenesis  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
HHEX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1287,057,379 - 7,063,326 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl287,057,283 - 7,063,330 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha287,233,996 - 7,239,896 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0287,317,251 - 7,323,151 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl287,317,203 - 7,323,145 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1287,037,744 - 7,043,641 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0287,072,416 - 7,078,310 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0287,236,847 - 7,242,744 (+)NCBIUU_Cfam_GSD_1.0
HHEX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381092,689,955 - 92,695,647 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1092,689,955 - 92,695,647 (+)EnsemblGRCh38hg38GRCh38
GRCh371094,449,712 - 94,455,404 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,439,661 - 94,445,388 (+)NCBINCBI36Build 36hg18NCBI36
Build 341094,439,691 - 94,445,383NCBI
Celera1088,191,085 - 88,196,812 (+)NCBICelera
Cytogenetic Map10q23.33NCBI
HuRef1088,076,253 - 88,081,980 (+)NCBIHuRef
CHM1_11094,732,137 - 94,737,863 (+)NCBICHM1_1
T2T-CHM13v2.01093,569,602 - 93,575,294 (+)NCBIT2T-CHM13v2.0
Hhex
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391937,423,289 - 37,429,179 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1937,423,258 - 37,429,179 (+)EnsemblGRCm39 Ensembl
GRCm381937,434,841 - 37,440,731 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1937,434,810 - 37,440,731 (+)EnsemblGRCm38mm10GRCm38
MGSCv371937,509,331 - 37,515,221 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361937,499,985 - 37,505,875 (+)NCBIMGSCv36mm8
Celera1938,221,629 - 38,227,525 (+)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.28NCBI
Hhex
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,602,945 - 244,608,532 (+)NCBIGRCr8
mRatBN7.21235,190,455 - 235,196,042 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,190,455 - 235,196,042 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1243,576,013 - 243,581,585 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01250,507,808 - 250,513,395 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,345,997 - 243,351,584 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01256,101,994 - 256,107,581 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1256,101,903 - 256,107,649 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01263,583,988 - 263,589,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41241,736,542 - 241,742,129 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11241,926,133 - 241,931,721 (+)NCBI
Celera1232,281,249 - 232,286,836 (+)NCBICelera
Cytogenetic Map1q53NCBI
Hhex
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955425735,378 - 742,775 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955425737,506 - 742,775 (-)NCBIChiLan1.0ChiLan1.0
HHEX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28104,725,043 - 104,730,830 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110104,730,394 - 104,736,144 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01089,433,402 - 89,439,137 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11092,947,373 - 92,952,992 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1092,947,373 - 92,952,992 (+)Ensemblpanpan1.1panPan2
Hhex
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721340,504,266 - 40,511,263 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366012,136,873 - 2,143,857 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366012,137,490 - 2,143,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HHEX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14104,194,343 - 104,200,219 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114104,194,424 - 104,199,684 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214113,794,343 - 113,799,603 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HHEX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1985,957,684 - 85,963,414 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl985,957,779 - 85,963,404 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604846,697,779 - 46,703,530 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hhex
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247373,897,871 - 3,904,083 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247373,897,907 - 3,903,828 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in HHEX
48 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 11 6 6 6 10 3
Low 5 5 11 6 6 12 8 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000012018   ⟹   ENSCAFP00000011144
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl287,057,283 - 7,063,330 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845030888   ⟹   ENSCAFP00845024209
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl287,317,203 - 7,323,145 (+)Ensembl
RefSeq Acc Id: XM_038439942   ⟹   XP_038295870
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0287,317,251 - 7,323,151 (+)NCBI
RefSeq Acc Id: XM_038514556   ⟹   XP_038370484
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1287,037,744 - 7,043,641 (+)NCBI
RefSeq Acc Id: XM_038578201   ⟹   XP_038434129
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0287,236,847 - 7,242,744 (+)NCBI
RefSeq Acc Id: XM_038642368   ⟹   XP_038498296
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0287,072,416 - 7,078,310 (+)NCBI
RefSeq Acc Id: XM_845111   ⟹   XP_850204
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1287,057,379 - 7,063,326 (+)NCBI
Dog10K_Boxer_Tasha287,233,996 - 7,239,896 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_850204   ⟸   XM_845111
- UniProtKB: A0A8C0QU02 (UniProtKB/TrEMBL),   A0A8C0Z3B6 (UniProtKB/TrEMBL),   A0A8I3NTG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000011144   ⟸   ENSCAFT00000012018
RefSeq Acc Id: XP_038370484   ⟸   XM_038514556
RefSeq Acc Id: XP_038498296   ⟸   XM_038642368
RefSeq Acc Id: XP_038295870   ⟸   XM_038439942
- UniProtKB: A0A8C0QU02 (UniProtKB/TrEMBL),   A0A8C0Z3B6 (UniProtKB/TrEMBL),   A0A8I3NTG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038434129   ⟸   XM_038578201
- UniProtKB: A0A8C0QU02 (UniProtKB/TrEMBL),   A0A8C0Z3B6 (UniProtKB/TrEMBL),   A0A8I3NTG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845024209   ⟸   ENSCAFT00845030888
Protein Domains
Homeobox

Promoters
RGD ID:13688263
Promoter ID:EPDNEW_C6331
Type:single initiation site
Name:HHEX_2
Description:hematopoietically expressed homeobox
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_C6332  
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1287,057,223 - 7,057,283EPDNEW
RGD ID:13688266
Promoter ID:EPDNEW_C6332
Type:multiple initiation site
Name:HHEX_1
Description:hematopoietically expressed homeobox
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_C6331  
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1287,057,413 - 7,057,473EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007502 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013689 UniProtKB/TrEMBL
  ENSCAFG00040020921 UniProtKB/TrEMBL
  ENSCAFG00845017433 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012018.6 UniProtKB/TrEMBL
  ENSCAFT00030025366.1 UniProtKB/TrEMBL
  ENSCAFT00040038796.1 UniProtKB/TrEMBL
  ENSCAFT00845030888 ENTREZGENE
  ENSCAFT00845030888.1 UniProtKB/TrEMBL
Gene3D-CATH Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Homeobox_metazoa UniProtKB/TrEMBL
KEGG Report cfa:608175 UniProtKB/TrEMBL
NCBI Gene HHEX ENTREZGENE
PANTHER HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX UniProtKB/TrEMBL
  HOMEOBOX PROTEIN HHEX UniProtKB/TrEMBL
Pfam Homeodomain UniProtKB/TrEMBL
PRINTS HOMEOBOX UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A8C0QU02 ENTREZGENE
  A0A8C0Z3B6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NTG1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41680 ENTREZGENE