Lgr5 (leucine rich repeat containing G protein coupled receptor 5) - Rat Genome Database

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Gene: Lgr5 (leucine rich repeat containing G protein coupled receptor 5) Rattus norvegicus
Analyze
Symbol: Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
RGD ID: 1307733
Description: Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; hair follicle development; and oocyte differentiation. Predicted to be located in trans-Golgi network membrane. Predicted to be active in plasma membrane. Orthologous to human LGR5 (leucine rich repeat containing G protein-coupled receptor 5); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: G protein-coupled receptor 49; Gpr49; leucine-rich repeat-containing G-protein coupled receptor 5; LOC299802
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8752,973,151 - 53,107,964 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl752,974,332 - 53,108,163 (-)EnsemblGRCr8
mRatBN7.2751,087,059 - 51,221,882 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl751,088,239 - 51,222,446 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx752,995,022 - 53,128,661 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0755,198,103 - 55,331,742 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0754,976,093 - 55,109,728 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0758,447,097 - 58,587,787 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl758,448,277 - 58,587,787 (-)Ensemblrn6Rnor6.0
Rnor_5.0758,458,486 - 58,596,253 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4754,737,745 - 54,876,664 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera747,880,362 - 48,010,031 (-)NCBICelera
RGSC_v3.1754,758,873 - 54,897,394 (-)NCBI
Cytogenetic Map7q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-bromoindirubin-3'-oxime  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CHIR 99021  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DAPT  (EXP)
deoxynivalenol  (ISO)
diarsenic trioxide  (ISO)
diiodine  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dodecanoic acid  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
genistein  (ISO)
glucose  (ISO)
glyphosate  (EXP)
hydrogen peroxide  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lithium chloride  (ISO)
menadione  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
paracetamol  (ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Sunset Yellow FCF  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
Golgi apparatus  (IEA)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)
trans-Golgi network membrane  (IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Secreted and transmembrane wnt inhibitors and activators. Cruciat CM and Niehrs C, Cold Spring Harb Perspect Biol. 2013 Mar 1;5(3):a015081. doi: 10.1101/cshperspect.a015081.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:21693646   PMID:21727895   PMID:21795542   PMID:22815884   PMID:23374535   PMID:23439653   PMID:24680895   PMID:25158167   PMID:25535395   PMID:26582901   PMID:27339869   PMID:29018960  


Genomics

Comparative Map Data
Lgr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8752,973,151 - 53,107,964 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl752,974,332 - 53,108,163 (-)EnsemblGRCr8
mRatBN7.2751,087,059 - 51,221,882 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl751,088,239 - 51,222,446 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx752,995,022 - 53,128,661 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0755,198,103 - 55,331,742 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0754,976,093 - 55,109,728 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0758,447,097 - 58,587,787 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl758,448,277 - 58,587,787 (-)Ensemblrn6Rnor6.0
Rnor_5.0758,458,486 - 58,596,253 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4754,737,745 - 54,876,664 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera747,880,362 - 48,010,031 (-)NCBICelera
RGSC_v3.1754,758,873 - 54,897,394 (-)NCBI
Cytogenetic Map7q22NCBI
LGR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381271,439,129 - 71,586,310 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1271,439,797 - 71,586,310 (+)Ensemblhg38GRCh38
GRCh371271,833,578 - 71,980,090 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361270,120,080 - 70,264,889 (+)NCBIBuild 36Build 36hg18NCBI36
Celera1271,496,570 - 71,640,955 (+)NCBICelera
Cytogenetic Map12q21.1NCBI
HuRef1268,883,082 - 69,029,217 (+)NCBIHuRef
CHM1_11271,801,182 - 71,947,319 (+)NCBICHM1_1
T2T-CHM13v2.01271,416,272 - 71,563,815 (+)NCBIT2T-CHM13v2.0
Lgr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910115,286,219 - 115,423,685 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10115,286,216 - 115,423,685 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3810115,450,314 - 115,587,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10115,450,311 - 115,587,780 (-)Ensemblmm10GRCm38
MGSCv3710114,887,370 - 115,024,836 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3610114,855,736 - 114,991,603 (-)NCBIMGSCv36mm8
Celera10117,380,191 - 117,518,061 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1063.51NCBI
Lgr5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540511,507,083 - 11,574,569 (+)Ensembl
ChiLan1.0NW_00495540511,507,083 - 11,574,504 (+)NCBIChiLan1.0ChiLan1.0
LGR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21079,468,978 - 79,616,542 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11279,465,378 - 79,612,941 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01268,963,423 - 69,110,107 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11271,823,622 - 71,969,712 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1271,823,511 - 71,969,704 (+)EnsemblpanPan2panpan1.1
LGR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11013,009,028 - 13,136,685 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1013,007,843 - 13,136,998 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1012,948,043 - 13,075,055 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01013,142,096 - 13,269,246 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1013,141,905 - 13,269,846 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11013,007,284 - 13,134,172 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01013,254,327 - 13,381,408 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01013,378,129 - 13,505,269 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lgr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494545,064,817 - 45,197,890 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936568530,188 - 663,520 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936568530,314 - 662,524 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl535,463,279 - 35,595,930 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1535,463,257 - 35,595,234 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2538,217,567 - 38,297,859 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LGR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11167,054,004 - 67,202,574 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1167,141,531 - 67,202,547 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037178,451,865 - 178,599,246 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgr5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475026,186,733 - 26,358,043 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475026,185,196 - 26,302,717 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lgr5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11193,627,221 - 193,694,446 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lgr5
587 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:49
Interacting mature miRNAs:60
Transcripts:ENSRNOT00000005814
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74511390390113903Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
10059605Kidm47Kidney mass QTL 472.910.05kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)74913799967614020Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)75170064396700643Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
631513Scl7Serum cholesterol level QTL 74.1blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)73984590284845902Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
10755453Coatc12Coat color QTL 120coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)73299870277998702Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)74968283263890004Rat
7411605Foco14Food consumption QTL 1424.10.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)73617876481178764Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74847504993475049Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631534Lnnr1Liver neoplastic nodule remodeling QTL 13.850.001liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)73617876481178764Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2303629Vencon3Ventilatory control QTL 37.25respiration trait (VT:0001943)respiration rate (CMO:0000289)74299622658678836Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
2303582Gluco53Glucose level QTL 533blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)74860308793603087Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
RH125648  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,210,448 - 51,210,722 (+)MAPPERmRatBN7.2
Rnor_6.0758,577,153 - 58,577,426NCBIRnor6.0
Rnor_5.0758,585,619 - 58,585,892UniSTSRnor5.0
RGSC_v3.4754,862,648 - 54,862,921UniSTSRGSC3.4
Celera747,998,852 - 47,999,125UniSTS
Cytogenetic Map7q22UniSTS
RH127654  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,209,874 - 51,210,093 (+)MAPPERmRatBN7.2
mRatBN7.2563,867,959 - 63,868,161 (+)MAPPERmRatBN7.2
Rnor_6.0564,784,687 - 64,784,888NCBIRnor6.0
Rnor_6.0758,576,579 - 58,576,797NCBIRnor6.0
Rnor_5.0758,585,045 - 58,585,263UniSTSRnor5.0
Rnor_5.0569,276,096 - 69,276,300UniSTSRnor5.0
RGSC_v3.4566,262,076 - 66,262,280UniSTSRGSC3.4
RGSC_v3.4754,862,074 - 54,862,292UniSTSRGSC3.4
Celera747,998,278 - 47,998,496UniSTS
Celera563,739,822 - 63,740,023UniSTS
RH 3.4 Map5563.39UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map5q22UniSTS
RH137145  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,210,570 - 51,210,778 (+)MAPPERmRatBN7.2
mRatBN7.2563,868,653 - 63,868,861 (+)MAPPERmRatBN7.2
Rnor_6.0564,785,381 - 64,785,588NCBIRnor6.0
Rnor_6.0758,577,275 - 58,577,482NCBIRnor6.0
Rnor_5.0758,585,741 - 58,585,948UniSTSRnor5.0
Rnor_5.0569,276,793 - 69,277,000UniSTSRnor5.0
RGSC_v3.4566,262,773 - 66,262,980UniSTSRGSC3.4
RGSC_v3.4754,862,770 - 54,862,977UniSTSRGSC3.4
Celera747,998,974 - 47,999,181UniSTS
Celera563,739,122 - 63,739,329UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map5q22UniSTS
AI598470  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,087,840 - 51,088,060 (+)MAPPERmRatBN7.2
Rnor_6.0758,447,879 - 58,448,098NCBIRnor6.0
Rnor_5.0758,459,268 - 58,459,487UniSTSRnor5.0
RGSC_v3.4754,737,347 - 54,737,566UniSTSRGSC3.4
Celera747,879,964 - 47,880,183UniSTS
RH 3.4 Map7477.41UniSTS
Cytogenetic Map7q22UniSTS
Lgr5  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,089,682 - 51,090,995 (+)MAPPERmRatBN7.2
Rnor_6.0758,449,721 - 58,451,033NCBIRnor6.0
Rnor_5.0758,461,110 - 58,462,422UniSTSRnor5.0
RGSC_v3.4754,739,189 - 54,740,501UniSTSRGSC3.4
Celera747,881,806 - 47,883,118UniSTS
Cytogenetic Map7q22UniSTS
UniSTS:546842  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2751,088,784 - 51,089,718 (+)MAPPERmRatBN7.2
Rnor_6.0758,448,823 - 58,449,756NCBIRnor6.0
Rnor_5.0758,460,212 - 58,461,145UniSTSRnor5.0
Celera747,880,908 - 47,881,841UniSTS
Cytogenetic Map7q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 7 59 139 89 88 58 33 58 6 275 121 10 118 73 92 30 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000005814   ⟹   ENSRNOP00000005814
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl752,974,332 - 53,108,163 (-)Ensembl
mRatBN7.2 Ensembl751,088,239 - 51,222,446 (-)Ensembl
Rnor_6.0 Ensembl758,448,277 - 58,587,787 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104830   ⟹   ENSRNOP00000092645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl752,974,332 - 53,108,163 (-)Ensembl
mRatBN7.2 Ensembl751,088,239 - 51,222,446 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115154   ⟹   ENSRNOP00000095923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl752,974,332 - 53,108,163 (-)Ensembl
mRatBN7.2 Ensembl751,088,239 - 51,222,446 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128088   ⟹   ENSRNOP00000106565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl752,974,332 - 53,108,163 (-)Ensembl
RefSeq Acc Id: NM_001106784   ⟹   NP_001100254
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8752,974,332 - 53,107,964 (-)NCBI
mRatBN7.2751,088,239 - 51,221,882 (-)NCBI
Rnor_6.0758,448,277 - 58,587,787 (-)NCBI
Rnor_5.0758,458,486 - 58,596,253 (-)NCBI
RGSC_v3.4754,737,745 - 54,876,664 (-)RGD
Celera747,880,362 - 48,010,031 (-)RGD
Sequence:
RefSeq Acc Id: XM_063263222   ⟹   XP_063119292
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8752,973,151 - 53,055,960 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100254 (Get FASTA)   NCBI Sequence Viewer  
  XP_063119292 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4AC13 (Get FASTA)   NCBI Sequence Viewer  
  EDM16685 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005814
  ENSRNOP00000005814.3
RefSeq Acc Id: NP_001100254   ⟸   NM_001106784
- Peptide Label: precursor
- UniProtKB: D4AC13 (UniProtKB/Swiss-Prot),   A0A8I6ARJ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005814   ⟸   ENSRNOT00000005814
Ensembl Acc Id: ENSRNOP00000095923   ⟸   ENSRNOT00000115154
Ensembl Acc Id: ENSRNOP00000092645   ⟸   ENSRNOT00000104830
RefSeq Acc Id: XP_063119292   ⟸   XM_063263222
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ARJ9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000106565   ⟸   ENSRNOT00000128088
Protein Domains
G-protein coupled receptors family 1 profile   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AC13-F1-model_v2 AlphaFold D4AC13 1-907 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307733 AgrOrtholog
BioCyc Gene G2FUF-34059 BioCyc
Ensembl Genes ENSRNOG00000004221 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005814 ENTREZGENE
  ENSRNOT00000005814.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Gphrmn_rcpt_fam UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
KEGG Report rno:299802 UniProtKB/Swiss-Prot
NCBI Gene 299802 ENTREZGENE
PANTHER GLYCOPROTEIN HORMONE RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
PhenoGen Lgr5 PhenoGen
PRINTS GLYCHORMONER UniProtKB/Swiss-Prot
  GPCRRHODOPSN UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
  LRR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004221 RatGTEx
SMART LRR_BAC UniProtKB/Swiss-Prot
  LRR_SD22 UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  LRRNT UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
  L domain-like UniProtKB/Swiss-Prot
UniProt A0A8I6ARJ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJW4_RAT UniProtKB/TrEMBL
  A0ABK0LNK0_RAT UniProtKB/TrEMBL
  D4AC13 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-17 Lgr5  leucine rich repeat containing G protein coupled receptor 5  LOC687868  similar to Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (G-protein coupled receptor 49) (Orphan G-protein coupled receptor FEX)  Data merged from RGD:1596235 1643240 APPROVED
2006-11-20 LOC687868  similar to Leucine-rich repeat-containing G-protein coupled receptor 5 precursor (G-protein coupled receptor 49) (Orphan G-protein coupled receptor FEX)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Lgr5  leucine rich repeat containing G protein coupled receptor 5  Gpr49_predicted  G protein-coupled receptor 49 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Gpr49_predicted  G protein-coupled receptor 49 (predicted)      Symbol and Name status set to approved 70820 APPROVED