Mc4r (melanocortin 4 receptor) - Rat Genome Database

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Gene: Mc4r (melanocortin 4 receptor) Rattus norvegicus
Analyze
Symbol: Mc4r
Name: melanocortin 4 receptor
RGD ID: 3057
Description: Enables melanocortin receptor activity and peptide hormone binding activity. Involved in several processes, including diet induced thermogenesis; negative regulation of feeding behavior; and regulation of grooming behavior. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. Used to study alcohol dependence; depressive disorder; and obesity. Biomarker of anxiety disorder; morphine dependence; obesity; and sciatic neuropathy. Human ortholog(s) of this gene implicated in morbid obesity and obesity. Orthologous to human MC4R (melanocortin 4 receptor); PARTICIPATES IN altered energy homeostasis pathway; altered melanocortin system pathway; G protein mediated signaling pathway via Galphas family; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MC4-R; melanocortin receptor 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Mc4rm1Hubr
Genetic Models: WI-Mc4rm1Hubr
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81862,689,798 - 62,691,685 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21860,419,832 - 60,421,719 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1860,419,832 - 60,421,719 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1862,493,750 - 62,495,636 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01863,192,468 - 63,194,354 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01861,044,927 - 61,046,814 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,612,838 - 62,614,725 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1862,612,838 - 62,614,725 (-)Ensemblrn6Rnor6.0
Rnor_5.01861,799,166 - 61,801,053 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41863,390,922 - 63,392,809 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1858,529,070 - 58,530,957 (-)NCBICelera
RGSC_v3.11863,464,122 - 63,465,631 (-)NCBI
RH 3.4 Map18610.4RGD
Cytogenetic Map18q12.1NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO,ISS)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction. Alvaro JD, etal., Mol Pharmacol. 1996 Sep;50(3):583-91.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge. Borges BC, etal., Am J Physiol Endocrinol Metab. 2011 May;300(5):E858-69. Epub 2011 Feb 22.
4. Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. Branson R, etal., N Engl J Med. 2003 Mar 20;348(12):1096-103.
5. The melanocortin system in control of inflammation. Catania A, etal., ScientificWorldJournal. 2010 Sep 14;10:1840-53.
6. Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Quebec Family Study. Chagnon YC, etal., Mol Med. 1997 Oct;3(10):663-73.
7. Melanocortin 4 receptor induces hyperalgesia and allodynia after chronic constriction injury by activation of p38 MAPK in DRG. Chu H, etal., Int J Neurosci. 2012 Feb;122(2):74-81. Epub 2011 Nov 24.
8. Perinatal exposure to environmental endocrine disruptor bisphenol A aggravates the onset of non-alcoholic fatty liver disease (NAFLD) in weanling F1 offspring of obese rats. Dabeer S and Raisuddin S, Environ Sci Pollut Res Int. 2023 Jan;30(2):3146-3165. doi: 10.1007/s11356-022-22246-y. Epub 2022 Aug 9.
9. Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland. Dhillo WS, etal., Biochem Biophys Res Commun 2003 Jan 31;301(1):102-7.
10. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. Farooqi IS, etal., N Engl J Med. 2003 Mar 20;348(12):1085-95.
11. Activation of Melanocortin-4 Receptor by a Synthetic Agonist Inhibits Ethanolinduced Neuroinflammation in Rats. Flores-Bastías O, etal., Curr Pharm Des. 2019;25(45):4799-4805. doi: 10.2174/1381612825666191216145153.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology. Gutierrez-Aguilar R, etal., Obesity (Silver Spring). 2012 Feb;20(2):306-12. doi: 10.1038/oby.2011.236. Epub 2011 Jul 21.
15. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Huszar D, etal., Cell. 1997 Jan 10;88(1):131-41.
16. Altered hypothalamic leptin, insulin, and melanocortin binding associated with moderate-fat diet and predisposition to obesity. Irani BG, etal., Endocrinology. 2007 Jan;148(1):310-6. Epub 2006 Oct 5.
17. Activation of melanocortin receptors in the intermediolateral cell column of the upper thoracic cord elicits tachycardia in the rat. Iwasa M, etal.
18. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors. Kim MS, etal., J Neuroendocrinol 2002 Apr;14(4):276-82.
19. Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. Kishi T, etal., J Comp Neurol 2003 Mar 10;457(3):213-35.
20. Involvement of alpha-melanocyte stimulating hormone (alpha-MSH) in differential ethanol exposure and withdrawal related depression in rat: neuroanatomical-behavioral correlates. Kokare DM, etal., Brain Res. 2008 Jun 24;1216:53-67. doi: 10.1016/j.brainres.2008.03.064. Epub 2008 Apr 6.
21. Adolescent Alcohol Exposure-Induced Changes in Alpha-Melanocyte Stimulating Hormone and Neuropeptide Y Pathways via Histone Acetylation in the Brain During Adulthood. Kokare DM, etal., Int J Neuropsychopharmacol. 2017 Sep 1;20(9):758-768. doi: 10.1093/ijnp/pyx041.
22. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
23. Anorectic actions of prolactin-releasing peptide are mediated by corticotropin-releasing hormone receptors. Lawrence CB, etal., Am J Physiol Regul Integr Comp Physiol 2004 Jan;286(1):R101-7. Epub 2003 Sep 25.
24. Melanocortin receptors in rat liver cells: change of gene expression and intracellular localization during acute-phase response. Malik IA, etal., Histochem Cell Biol. 2012 Mar;137(3):279-91. Epub 2011 Dec 20.
25. A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity. Mergen M, etal., J Clin Endocrinol Metab. 2001 Jul;86(7):3448.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat. Mul JD, etal., Obesity (Silver Spring). 2012 Mar;20(3):612-21. doi: 10.1038/oby.2011.81. Epub 2011 Apr 28.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
30. A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration. Peter JC, etal., J Pharmacol Exp Ther. 2010 May;333(2):478-90. Epub 2010 Jan 29.
31. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. GOA pipeline RGD automated data pipeline
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure. Scarlett JM, etal., J Endocrinol. 2010 Jul;206(1):121-30. Epub 2010 Apr 6.
36. The critical role of the melanocortin system in the control of energy balance. Seeley RJ, etal., Annu Rev Nutr 2004;24:133-49.
37. Alpha-melanocyte stimulating hormone modulates ethanol self-administration in posterior ventral tegmental area through melanocortin-4 receptors. Shelkar GP, etal., Addict Biol. 2015 Mar;20(2):302-15. doi: 10.1111/adb.12126. Epub 2014 Mar 18.
38. Peripheral antinociceptive effects of MC4 receptor antagonists in a rat model of neuropathic pain - a biochemical and behavioral study. Starowicz K, etal., Pharmacol Rep. 2009 Nov-Dec;61(6):1086-95.
39. Vascular effects of deletion of melanocortin-4 receptors in rats. Stepp DW, etal., Physiol Rep. 2013 Nov;1(6):e00146. doi: 10.1002/phy2.146. Epub 2013 Nov 13.
40. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
41. Systematic generation of in vivo G protein-coupled receptor mutants in the rat. van Boxtel R, etal., Pharmacogenomics J. 2011 Oct;11(5):326-36. doi: 10.1038/tpj.2010.44. Epub 2010 Jun 8.
42. Hypothalamic melanocortin system regulates sympathetic nerve activity in brown adipose tissue. Yasuda T, etal., Exp Biol Med (Maywood). 2004 Mar;229(3):235-9.
43. Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms. Yeo GS, etal., Hum Mol Genet. 2003 Mar 1;12(5):561-74.
Additional References at PubMed
PMID:9454589   PMID:12675910   PMID:12736185   PMID:12796784   PMID:12959974   PMID:12960080   PMID:14660008   PMID:14688446   PMID:14764818   PMID:15026153   PMID:15033920   PMID:15123576  
PMID:15585943   PMID:15720470   PMID:15927146   PMID:16141392   PMID:16325304   PMID:16380516   PMID:16384863   PMID:16614075   PMID:17595227   PMID:18285617   PMID:18463249   PMID:18492813  
PMID:19297540   PMID:19329486   PMID:19737927   PMID:19743876   PMID:19817504   PMID:19854868   PMID:20817751   PMID:20884347   PMID:20963574   PMID:21803120   PMID:22176700   PMID:22390932  
PMID:22535749   PMID:22643233   PMID:22872662   PMID:22889616   PMID:23416175   PMID:23571710   PMID:23946387   PMID:24433867   PMID:24612112   PMID:24636506   PMID:25371525   PMID:25668357  
PMID:25695289   PMID:25977231   PMID:25997563   PMID:26547948   PMID:26593415   PMID:27412936   PMID:27534879   PMID:27713523   PMID:28409883   PMID:30466186   PMID:30745360   PMID:31260713  
PMID:32035118   PMID:32378055   PMID:35304172   PMID:38960135  


Genomics

Comparative Map Data
Mc4r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81862,689,798 - 62,691,685 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21860,419,832 - 60,421,719 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1860,419,832 - 60,421,719 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1862,493,750 - 62,495,636 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01863,192,468 - 63,194,354 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01861,044,927 - 61,046,814 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,612,838 - 62,614,725 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1862,612,838 - 62,614,725 (-)Ensemblrn6Rnor6.0
Rnor_5.01861,799,166 - 61,801,053 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41863,390,922 - 63,392,809 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1858,529,070 - 58,530,957 (-)NCBICelera
RGSC_v3.11863,464,122 - 63,465,631 (-)NCBI
RH 3.4 Map18610.4RGD
Cytogenetic Map18q12.1NCBI
MC4R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381860,371,062 - 60,372,775 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1860,371,062 - 60,372,775 (-)Ensemblhg38GRCh38
GRCh371858,038,295 - 58,040,008 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361856,189,544 - 56,190,981 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341856,189,563 - 56,190,562NCBI
Celera1854,756,638 - 54,758,075 (-)NCBICelera
Cytogenetic Map18q21.32NCBI
HuRef1854,747,886 - 54,749,323 (-)NCBIHuRef
CHM1_11858,034,197 - 58,035,634 (-)NCBICHM1_1
T2T-CHM13v2.01860,574,034 - 60,575,747 (-)NCBIT2T-CHM13v2.0
Mc4r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391866,990,776 - 66,993,558 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1866,990,775 - 66,993,577 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381866,857,705 - 66,860,487 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1866,857,704 - 66,860,506 (-)Ensemblmm10GRCm38
MGSCv371867,017,359 - 67,020,126 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361866,983,074 - 66,985,841 (-)NCBIMGSCv36mm8
Celera1868,131,723 - 68,134,491 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.72NCBI
Mc4r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540244,455,294 - 44,456,292 (-)Ensembl
ChiLan1.0NW_00495540244,453,973 - 44,456,689 (-)NCBIChiLan1.0ChiLan1.0
MC4R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21777,895,644 - 77,900,374 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11863,588,255 - 63,592,920 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01853,744,172 - 53,747,282 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11857,069,089 - 57,070,670 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1857,069,259 - 57,070,257 (-)EnsemblpanPan2panpan1.1
MC4R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1116,131,829 - 16,132,827 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl116,131,589 - 16,133,079 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha117,102,321 - 17,103,318 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0116,003,681 - 16,004,679 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl116,003,441 - 16,004,931 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1116,032,383 - 16,033,381 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0115,964,379 - 15,965,377 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0116,214,421 - 16,215,419 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mc4r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494429,397,280 - 29,400,818 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364974,636,758 - 4,637,759 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364974,636,370 - 4,638,205 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MC4R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1160,772,013 - 160,774,124 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11160,772,013 - 160,774,124 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21178,553,488 - 178,555,752 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MC4R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11819,380,054 - 19,386,412 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1819,380,849 - 19,381,847 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660606,249,695 - 6,251,517 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mc4r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247925,866,119 - 5,867,120 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247925,865,902 - 5,867,498 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Mc4r
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11564,415,249 - 64,417,181 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mc4r
6 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:145
Count of miRNA genes:117
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000025223
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182507112683910656Rat
1331730Scl27Serum cholesterol level QTL 273.826blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)185449080186134022Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182349405785487725Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185335052168120379Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)183857591983575919Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182682218671822186Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182682218671822186Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182682218671822186Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184562030686134022Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050563968306Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182682218671822186Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184891573786134022Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184891573786134022Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182682218671822186Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182682218671822186Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183199089176990891Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)184562030686134022Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186198220476619168Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181206648285493247Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183161050585493247Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)183337915878379158Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)186144685386134022Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)184046238385462383Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185449080176272247Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186160038472538878Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)183199089176990891Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185449080168120379Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181206648285493247Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181564228086134022Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)183337915878379158Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183161050577371277Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)183337915878379158Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)183337915878379158Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185079521286134022Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182682218671822186Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183152278376522783Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)183337915878379158Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183337915878379158Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)183337915878379158Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185782524385493247Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183161050577371277Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183612162681121626Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)183199089176990891Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184891573786134022Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)182641582171415821Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183164450879484311Rat
1598832Glom11Glomerulus QTL 112.9kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)185326667186134022Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181955353285493247Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)183199089176990891Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)185079521286134022Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183161050572538878Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)185219805968120379Rat

Markers in Region
D18Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41863,737,840 - 63,737,956UniSTSRGSC3.4
RGSC_v3.41863,737,839 - 63,737,956RGDRGSC3.4
Celera1858,870,895 - 58,871,011UniSTS
RGSC_v3.11863,811,040 - 63,811,157RGD
RH 3.4 Map18616.3RGD
RH 2.0 Map18298.8RGD
MC4R  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,420,460 - 60,420,938 (+)MAPPERmRatBN7.2
Rnor_6.01862,613,467 - 62,613,944NCBIRnor6.0
Rnor_5.01861,799,795 - 61,800,272UniSTSRnor5.0
RGSC_v3.41863,391,551 - 63,392,028UniSTSRGSC3.4
Celera1858,529,699 - 58,530,176UniSTS
Cytogenetic Map18q12.1UniSTS
RH94805  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,419,838 - 60,420,092 (+)MAPPERmRatBN7.2
Rnor_6.01862,612,845 - 62,613,098NCBIRnor6.0
Rnor_5.01861,799,173 - 61,799,426UniSTSRnor5.0
RGSC_v3.41863,390,929 - 63,391,182UniSTSRGSC3.4
Celera1858,529,077 - 58,529,330UniSTS
RH 3.4 Map18610.4UniSTS
Cytogenetic Map18q12.1UniSTS
PMC314306P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,420,654 - 60,420,924 (+)MAPPERmRatBN7.2
Rnor_6.01862,613,661 - 62,613,930NCBIRnor6.0
Rnor_5.01861,799,989 - 61,800,258UniSTSRnor5.0
RGSC_v3.41863,391,745 - 63,392,014UniSTSRGSC3.4
Celera1858,529,893 - 58,530,162UniSTS
Cytogenetic Map18q12.1UniSTS


Genetic Models
This gene Mc4r is modified in the following models/strains:
WI-Mc4rm1Hubr    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 8 36 111 19 27 8 13 8 5 127 60 1 102 46 62 19 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000025223   ⟹   ENSRNOP00000025223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1860,419,832 - 60,421,719 (-)Ensembl
Rnor_6.0 Ensembl1862,612,838 - 62,614,725 (-)Ensembl
RefSeq Acc Id: NM_013099   ⟹   NP_037231
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81862,689,798 - 62,691,685 (-)NCBI
mRatBN7.21860,419,832 - 60,421,719 (-)NCBI
Rnor_6.01862,612,838 - 62,614,725 (-)NCBI
Rnor_5.01861,799,166 - 61,801,053 (-)NCBI
RGSC_v3.41863,390,922 - 63,392,809 (-)RGD
Celera1858,529,070 - 58,530,957 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037231 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB36517 (Get FASTA)   NCBI Sequence Viewer  
  EDM14715 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025223.1
GenBank Protein P70596 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_037231   ⟸   NM_013099
- UniProtKB: P70596 (UniProtKB/Swiss-Prot),   A6IXT4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025223   ⟸   ENSRNOT00000025223
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70596-F1-model_v2 AlphaFold P70596 1-332 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3057 AgrOrtholog
BioCyc Gene G2FUF-7170 BioCyc
Ensembl Genes ENSRNOG00000018692 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025223.4 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Mcort_rcpt_4 UniProtKB/Swiss-Prot
  Melancort_rcpt UniProtKB/Swiss-Prot
  Melcrt_ACTH_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:25635 UniProtKB/Swiss-Prot
NCBI Gene 25635 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Mc4r PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  MCRFAMILY UniProtKB/Swiss-Prot
  MELNOCORTINR UniProtKB/Swiss-Prot
  MELNOCORTN4R UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018692 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC215097
UniProt A6IXT4 ENTREZGENE, UniProtKB/TrEMBL
  MC4R_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Mc4r  Melanocortin 4 receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression found in infralimbic and insular cortices, bed nucleus of the stria terminalis, central nucleus of the amygdala, periaqueductal gray, lateral parabrachial nucleus, nucleus of the solitary tract, dorsal motor nucleus of the vagus (DMV), and intermediolateral nucleus of the spinal cord (IML) 727498
gene_process may be involved in stimulating TRH release 729360