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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:hepatocyte growth factor receptor signaling pathway
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Accession:GO:0048012 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to a hepatocyte growth factor receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: HGF receptor signaling pathway;   HGF receptor signalling pathway
 narrow_synonym: Met signaling pathway
 xref: Reactome:R-HSA-8852405 "Signaling by MST1"


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hepatocyte growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in ISO
IEA 		(PMID:21245381)
GO_REF:0000107 		RGD
Ensembl		 PMID:21245381 GO_REF:0000107 NCBI chr19:56,588,500...56,623,190
Ensembl chr19:56,588,500...56,623,190 		JBrowse link
G Cdcp1 CUB domain containing protein 1 acts_upstream_of_or_within ISO (PMID:33574034) RGD PMID:33574034 NCBI chr 8:131,706,140...131,742,799
Ensembl chr 8:131,706,140...131,742,877 		JBrowse link
G Hgf hepatocyte growth factor involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:21245381)
GO_REF:0000107
GO_REF:0000033
(PMID:15314156), (PMID:21072211) 		RGD
Ensembl
GO_Central		 PMID:15314156 PMID:21072211 PMID:21245381 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851 		JBrowse link
G LOC102551813 stathmin-like involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 8:96,217,025...96,222,032
Ensembl chr 5:151,964,351...151,970,842 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase involved_in
acts_upstream_of_or_within 		IEA
ISO 		GO_REF:0000108
(PMID:25198505)
(PMID:15314156)
GO_REF:0000107 		GOC
RGD
Ensembl		 PMID:15314156 PMID:25198505 GO_REF:0000107 GO_REF:0000108 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:46,756,506...46,870,821 		JBrowse link
G Muc20 mucin 20, cell surface associated involved_in
acts_upstream_of_or_within 		IEA
ISO 		GO_REF:0000002
(PMID:15314156) 		InterPro
RGD		 PMID:15314156 GO_REF:0000002 NCBI chr11:81,492,844...81,506,571
Ensembl chr11:81,492,891...81,506,571 		JBrowse link
G Nrp1 neuropilin 1 involved_in ISO (PMID:21245381) RGD PMID:21245381 NCBI chr19:73,256,557...73,411,705
Ensembl chr19:73,256,557...73,411,702 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 involved_in ISO
IEA 		(PMID:25198505)
GO_REF:0000107 		RGD
Ensembl		 PMID:25198505 GO_REF:0000107 NCBI chr 1:161,522,399...161,637,623
Ensembl chr 1:161,491,847...161,637,612 		JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO (PMID:25198505) RGD PMID:25198505 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109 		JBrowse link
G Stmn1 stathmin 1 involved_in ISO
IEA 		(PMID:25198505)
GO_REF:0000107 		RGD
Ensembl		 PMID:25198505 GO_REF:0000107 NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:151,964,351...151,970,842 		JBrowse link
negative regulation of hepatocyte growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 involved_in ISO
IEA 		(PMID:17895370)
GO_REF:0000107 		RGD
Ensembl		 PMID:17895370 GO_REF:0000107 NCBI chr 2:61,759,975...62,054,716
Ensembl chr 2:61,759,987...62,054,716 		JBrowse link
positive regulation of hepatocyte growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esm1 endothelial cell-specific molecule 1 involved_in ISO
IBA
IEA 		(PMID:11590178)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:11590178 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:46,609,253...46,617,991
Ensembl chr 2:46,609,204...46,617,990 		JBrowse link
regulation of hepatocyte growth factor receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO
IEA 		(PMID:18819921)
GO_REF:0000107 		RGD
Ensembl		 PMID:18819921 GO_REF:0000107 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
IEA
ISS 		(PMID:18819921)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:18819921 GO_REF:0000024 GO_REF:0000107 NCBI chr18:63,498,890...63,564,571
Ensembl chr18:63,498,890...63,564,481 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19688
    cellular process 18845
      signal transduction 7248
        cell surface receptor signaling pathway 2949
          enzyme-linked receptor protein signaling pathway 1106
            cell surface receptor protein tyrosine kinase signaling pathway 693
              hepatocyte growth factor receptor signaling pathway 14
                negative regulation of hepatocyte growth factor receptor signaling pathway 1
                positive regulation of hepatocyte growth factor receptor signaling pathway 1
                regulation of hepatocyte growth factor receptor signaling pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 19688
    biological regulation 13561
      regulation of biological process 13114
        signaling 7810
          signal transduction 7248
            cell surface receptor signaling pathway 2949
              enzyme-linked receptor protein signaling pathway 1106
                cell surface receptor protein tyrosine kinase signaling pathway 693
                  hepatocyte growth factor receptor signaling pathway 14
                    negative regulation of hepatocyte growth factor receptor signaling pathway 1
                    positive regulation of hepatocyte growth factor receptor signaling pathway 1
                    regulation of hepatocyte growth factor receptor signaling pathway + 4
paths to the root