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ONTOLOGY REPORT - ANNOTATIONS

Term:leptin-mediated signaling pathway
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Accession:GO:0033210 term browser browse the term
Definition:The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
Synonyms:exact_synonym: leptin-mediated signalling pathway
 related_synonym: adipocytokine signaling pathway


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leptin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acbd7 acyl-CoA binding domain containing 7 acts_upstream_of_or_within ISO (PMID:26880548) RGD PMID:26880548 NCBI chr17:79,813,106...79,821,254
Ensembl chr17:79,813,106...79,818,448 		JBrowse link
G Adipor1 adiponectin receptor 1 IMP RGD PMID:18394428 RGD:2317907 NCBI chr13:48,411,438...48,431,251
Ensembl chr13:48,411,826...48,431,255 		JBrowse link
G Bbs2 Bardet-Biedl syndrome 2 acts_upstream_of_or_within ISO MGI:3521669 (PMID:19150989) RGD PMID:19150989 NCBI chr19:10,915,566...10,950,911
Ensembl chr19:10,915,476...10,950,921 		JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 acts_upstream_of_or_within ISO MGI:3045473 (PMID:19150989), (PMID:33426789) RGD PMID:19150989 PMID:33426789 NCBI chr 8:68,627,739...68,661,232
Ensembl chr 8:68,627,656...68,661,358 		JBrowse link
G Lep leptin involved_in IDA
ISO
IEA 		(PMID:16825198)
GO_REF:0000117
GO_REF:0000107
(PMID:27037668)
PMID:11677594 		RGD
UniProt
Ensembl		 PMID:16825198 PMID:27037668 PMID:9070213 PMID:9618284 PMID:11677594 GO_REF:0000107 GO_REF:0000117, RGD:2290293, RGD:2290294, RGD:10448951 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Lepr leptin receptor involved_in IDA
ISO
IEA 		(PMID:12594516)
GO_REF:0000117
GO_REF:0000107
(PMID:27037668) 		RGD
UniProt
Ensembl		 PMID:12594516 PMID:27037668 PMID:9070213 PMID:9618284 GO_REF:0000107 GO_REF:0000117, RGD:2290293, RGD:2290294 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Lepr_v1 leptin receptor, variant 1 IDA RGD PMID:9070213 PMID:9618284 RGD:2290293, RGD:2290294
G Lepr_v2 leptin receptor, variant 2 IDA RGD PMID:9070213 PMID:9618284 RGD:2290293, RGD:2290294
G Mkks MKKS centrosomal shuttling protein acts_upstream_of_or_within ISO MGI:3526444 (PMID:19150989) RGD PMID:19150989 NCBI chr 3:144,654,563...144,672,831
Ensembl chr 3:144,654,566...144,672,831 		JBrowse link
G Mt3 metallothionein 3 involved_in ISO (PMID:21726645) RGD PMID:21726645 NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:20620997) RGD PMID:20620997 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISS
ISO
IBA
IEA 		GO_REF:0000024
(PMID:12594516), (PMID:16825198)
GO_REF:0000033
GO_REF:0000107
(PMID:17344214) 		UniProt
RGD
GO_Central
Ensembl		 PMID:12594516 PMID:16825198 PMID:17344214 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:23554574)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:23554574 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:78,828,006...78,860,725
Ensembl chr 5:78,828,006...78,860,417 		JBrowse link
negative regulation of appetite by leptin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbs2 Bardet-Biedl syndrome 2 involved_in IEA
ISO 		GO_REF:0000107
(PMID:19150989) 		Ensembl
RGD		 PMID:19150989 GO_REF:0000107 NCBI chr19:10,915,566...10,950,911
Ensembl chr19:10,915,476...10,950,921 		JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 involved_in IEA
ISO 		GO_REF:0000107
(PMID:19150989) 		Ensembl
RGD		 PMID:19150989 GO_REF:0000107 NCBI chr 8:68,627,739...68,661,232
Ensembl chr 8:68,627,656...68,661,358 		JBrowse link
G Lep leptin involved_in IDA
IBA 		PMID:11677594
GO_REF:0000033 		GO_Central PMID:11677594 GO_REF:0000033, RGD:10448951 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661 		JBrowse link
G Mkks MKKS centrosomal shuttling protein involved_in IEA
ISO 		GO_REF:0000107
(PMID:19150989) 		Ensembl
RGD		 PMID:19150989 GO_REF:0000107 NCBI chr 3:144,654,563...144,672,831
Ensembl chr 3:144,654,566...144,672,831 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19665
    cellular process 18832
      signal transduction 7243
        cell surface receptor signaling pathway 2949
          cytokine-mediated signaling pathway 515
            leptin-mediated signaling pathway 13
              negative regulation of appetite by leptin-mediated signaling pathway 4
Path 2
Term Annotations click to browse term
  biological_process 19665
    biological regulation 13556
      regulation of biological process 13124
        signaling 7822
          signal transduction 7243
            cell surface receptor signaling pathway 2949
              cytokine-mediated signaling pathway 515
                leptin-mediated signaling pathway 13
                  negative regulation of appetite by leptin-mediated signaling pathway 4
paths to the root